Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 52 (18 Sep 2019)
Sequence version 1 (28 Jun 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Y' element ATP-dependent helicase protein 1 copy 5

Gene

YRF1-5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi810 – 817ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • telomere maintenance via recombination Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32517-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Y' element ATP-dependent helicase protein 1 copy 5 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YRF1-5
Ordered Locus Names:YLR467W
ORF Names:L9040
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004459 YRF1-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004097561 – 1796Y' element ATP-dependent helicase protein 1 copy 5Add BLAST1796

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0CX21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in absence of telomerase TLC1.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31723, 18 interactors
32590, 30 interactors
34775, 4 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini797 – 974Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST178
Domaini1031 – 1180Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR021646 Sir1_ORC-binding

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF11603 Sir1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CX21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE
60 70 80 90 100
KSGLIKVVKF RTGAMDRKRS FEKIVISVMV GKNVQKFLTF VEDEPDFQGG
110 120 130 140 150
PIPSKYLIPK KINLMVYTLF QVHTLKFNRK DYDTLSLFYL NRGYYNELSF
160 170 180 190 200
RVLERCHEIA SARPNDSSTM RTFTDFVSGA PIVRSLQKST IRKYGYNLAP
210 220 230 240 250
YMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK PIEIKYFSQI
260 270 280 290 300
CNDMMNKKDR LGDILHIILR ACALNFGAGP RGGAGDEEDR SITNEEPIIP
310 320 330 340 350
SVDEHGLKVC KLRSPNTPRR LRKTLDAVKA LLVSSCACTA RDLDIFDDTN
360 370 380 390 400
GVAMWKWIKI LYHEVAQETT LKDSYRITLV PSSDGISVCG KLFNREYVRG
410 420 430 440 450
FYFACKAQFD NLWGELNNCF YMPTVVDIAS LILRNREVLF REPKRGIDEY
460 470 480 490 500
LENDSFLQMI PVKYREIVLP KLRRDTNKMT AALKNKVTVA IDELTVPLMW
510 520 530 540 550
MVHFAVGYPY RYPELQLLAF AGPQRNVYVD DTTRRIQLYT DYNKNGSSEP
560 570 580 590 600
RLKTLDGLTS DYVFYFVTVL RQMQICALGN SYDAFNHDPW MDVVGFEDPD
610 620 630 640 650
QVTNRDISRI VLYSYMFLNT AKGCLVEYAT FRQYMRELPK NAPQKLNFRE
660 670 680 690 700
MRQGLIALGR HCVGSRFETD LYESATSELM ANHSVQTGRN IYGVDSFSLT
710 720 730 740 750
SVSGTTATLL QERASERWIQ WLGLESDYHC SFSSTRNAED VVAGEAASSD
760 770 780 790 800
HDQKISRVTR KRPREPKSTN DILVAGQKLF GSSFEFRDLH QLRLCHEIYM
810 820 830 840 850
ADTPSVAVQA PPGYGKTELF HLPLIALASK GDVKYVSFLF VPYTVLLANC
860 870 880 890 900
MIRLSRCGCL NVAPVRNFIE EGCDGVTDLY VGIYDDLAST NFTDRIAAWE
910 920 930 940 950
NIVECTFRTN NVKLGYLIVD EFHNFETEVY RQSQFGGITN LDFDAFEKAI
960 970 980 990 1000
FLSGTAPEAV ADAALQRIGL TGLAKKSMDI NELKRSEDLS RGLSSYPTRM
1010 1020 1030 1040 1050
FNLIKEKSEV PLGHVHKIWK KVESQPEEAL KLLLALFEIE PESKAIVVAS
1060 1070 1080 1090 1100
TTNEVEELAC SWRKYFRVVW IHGKLGAAEK VSRTKEFVTD GSMRVLIGTK
1110 1120 1130 1140 1150
LVTEGIDIKQ LMMVIMLDNR LNIIELIQGV GRLRDGGLCY LLSRKNSWAA
1160 1170 1180 1190 1200
RNRKGELPPI KEGCITEQVR EFYGLESKKG KKGQHVGCCG SRTDLSADTV
1210 1220 1230 1240 1250
ELIERMDRLA EKQATASMSI IALPSSFQES NSSDRCRKYC SSDEDSDTCI
1260 1270 1280 1290 1300
HGSANASTNA TTNSSTNATT TASTNVRTSA TTTASINVRT SAITTESTNS
1310 1320 1330 1340 1350
STNATTTAST NVRTSATTTA SINVRTSATT TESTNSNTSA TTTESTDSNT
1360 1370 1380 1390 1400
SATTTESTDS NTSATTTAST NSSTNATTTA STNSSTNATT TESTNASAKE
1410 1420 1430 1440 1450
DANKDGNAED NRFHPVTDIN KESYKRKGSQ MVLLERKKLK AQFPNTSENM
1460 1470 1480 1490 1500
NVLQFLGFRS DEIKHLFLYG IDVYFCPEGV FTQYGLCKGC QKMFELCVCW
1510 1520 1530 1540 1550
AGQKVSYRRM AWEALAVERM LRNDEEYKEY LEDIEPYHGD PVGYLKYFSV
1560 1570 1580 1590 1600
KRGEIYSQIQ RNYAWYLAIT RRRETISVLD STRGKQGSQV FRMSGRQIKE
1610 1620 1630 1640 1650
LYYKVWSNLR ESKTEVLQYF LNWDEKKCRE EWEAKDDTVF VEALEKVGVF
1660 1670 1680 1690 1700
QRLRSMTSAG LQGPQYVKLQ FSRHHRQLRS RYELSLGMHL RDQLALGVTP
1710 1720 1730 1740 1750
SKVPHWTAFL SMLIGLFYNK TFRQKLEYLL EQISEVWLLP HWLDLANVEV
1760 1770 1780 1790
LAADNTRVPL YMLMVAVHKE LDSDDVPDGR FDIILLCRDS SREVGE
Length:1,796
Mass (Da):203,781
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC241E78ABBB6FF1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z73327 Genomic DNA Translation: CAA97727.1
U22383 Genomic DNA Translation: AAB64730.1
BK006945 Genomic DNA Translation: DAA09765.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S65004

NCBI Reference Sequences

More...
RefSeqi
NP_010834.1, NM_001180853.1
NP_013572.3, NM_001182355.3
NP_061495.4, NM_001184447.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR545W_mRNA; YDR545W; YDR545W
YLR467W_mRNA; YLR467W; YLR467W
YOR396W_mRNA; YOR396W; YOR396W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851189
852158
854577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR545W
sce:YLR467W
sce:YOR396W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73327 Genomic DNA Translation: CAA97727.1
U22383 Genomic DNA Translation: AAB64730.1
BK006945 Genomic DNA Translation: DAA09765.1
PIRiS65004
RefSeqiNP_010834.1, NM_001180853.1
NP_013572.3, NM_001182355.3
NP_061495.4, NM_001184447.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi31723, 18 interactors
32590, 30 interactors
34775, 4 interactors

Proteomic databases

PRIDEiP0CX21

Genome annotation databases

EnsemblFungiiYDR545W_mRNA; YDR545W; YDR545W
YLR467W_mRNA; YLR467W; YLR467W
YOR396W_mRNA; YOR396W; YOR396W
GeneIDi851189
852158
854577
KEGGisce:YDR545W
sce:YLR467W
sce:YOR396W

Organism-specific databases

SGDiS000004459 YRF1-5

Enzyme and pathway databases

BioCyciYEAST:G3O-32517-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CX21

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR021646 Sir1_ORC-binding
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF11603 Sir1, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYRF15_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CX21
Secondary accession number(s): D6VTG2
, O94087, P24088, P24089, Q53WX0, Q99313
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 18, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again