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UniProtKB - P0CX08 (DSF1_YEAST)
Protein
Mannitol dehydrogenase DSF1
Gene
DSF1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.
1 PublicationMiscellaneous
There are two genes for this mannitol dehydrogenase in yeast, DSF1 and YNR073C.
Present with 125 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.1.1.671 Publication
Kineticsi
- KM=2.9 mM for mannitol1 Publication
- KM=869.6 mM for sorbitol1 Publication
- Vmax=0.1 µmol/min/mg enzyme toward mannitol1 Publication
- Vmax=1.5 µmol/min/mg enzyme toward sorbitol1 Publication
GO - Molecular functioni
- mannitol 2-dehydrogenase activity Source: UniProtKB-EC
- mannitol dehydrogenase activity Source: SGD
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
GO - Biological processi
- mannitol metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Mannitol dehydrogenase DSF11 Publication (EC:1.1.1.671 Publication)Alternative name(s): Deletion suppressor of MPT5 mutation protein 11 Publication |
Gene namesi | Ordered Locus Names:YEL070W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000796, DSF1 |
VEuPathDBi | FungiDB:YEL070W FungiDB:YNR073C |
Pathology & Biotechi
Disruption phenotypei
Rescues temperature-sensitivity of MPT5 deletion.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000170751 | 1 – 502 | Mannitol dehydrogenase DSF1Add BLAST | 502 |
Proteomic databases
PaxDbi | P0CX08 |
PRIDEi | P0CX08 |
TopDownProteomicsi | P0CX08 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35899, 81 interactors 36661, 56 interactors |
STRINGi | 4932.YEL070W |
Miscellaneous databases
RNActi | P0CX08, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannitol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QT30, Eukaryota |
HOGENOMi | CLU_027324_0_1_1 |
InParanoidi | P0CX08 |
OMAi | YKPYDNL |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR023027, Mannitol_DH_CS IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00974, MANNITOL_DHGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CX08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKSDETTAT SLNAKTLKSF ESTLPIPTYP REGVKQGIVH LGVGAFHRSH
60 70 80 90 100
LAVFMHRLMQ EHHLKDWSIC GVGLMKADAL MRDAMKAQDC LYTLVERGIK
110 120 130 140 150
DTNAYIVGSI TAYMYAPDDP RAVIEKMANP DTHIVSLTVT ENGYYHSEAT
160 170 180 190 200
NSLMTDAPEI INDLNHPEKP DTLYGYLYEA LLLRYKRGLT PFTIMSCDNM
210 220 230 240 250
PQNGVTVKTM LVAFAKLKKD EKFAAWIEDK VTSPNSMVDR VTPRCTDKER
260 270 280 290 300
KYVADTWGIK DQCPVVAEPF IQWVLEDNFS DGRPPWELVG VQVVKDVDSY
310 320 330 340 350
ELMKLRLLNG GHSAMGYLGY LAGYTYIHEV VNDPTINKYI RVLMREEVIP
360 370 380 390 400
LLPKVPGVDF EEYTASVLER FSNPAIQDTV ARICLMGSGK MPKYVLPSIY
410 420 430 440 450
EQLRKPDGKY KLLAVCVAGW FRYLTGVDMN GKPFEIEDPM APTLKAAAVK
460 470 480 490 500
GGKDPHELLN IEVLFSPEIR DNKEFVAQLT HSLETVYDKG PIAAIKEILD
QV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18795 Genomic DNA Translation: AAB65017.1 BK006939 Genomic DNA Translation: DAA07585.1 |
PIRi | S50519 |
RefSeqi | NP_010844.1, NM_001178885.1 NP_014471.3, NM_001183250.3 |
Genome annotation databases
EnsemblFungii | YEL070W_mRNA; YEL070W; YEL070W YNR073C_mRNA; YNR073C; YNR073C |
GeneIDi | 855810 856639 |
KEGGi | sce:YEL070W sce:YNR073C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18795 Genomic DNA Translation: AAB65017.1 BK006939 Genomic DNA Translation: DAA07585.1 |
PIRi | S50519 |
RefSeqi | NP_010844.1, NM_001178885.1 NP_014471.3, NM_001183250.3 |
3D structure databases
AlphaFoldDBi | P0CX08 |
SMRi | P0CX08 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35899, 81 interactors 36661, 56 interactors |
STRINGi | 4932.YEL070W |
Proteomic databases
PaxDbi | P0CX08 |
PRIDEi | P0CX08 |
TopDownProteomicsi | P0CX08 |
Genome annotation databases
EnsemblFungii | YEL070W_mRNA; YEL070W; YEL070W YNR073C_mRNA; YNR073C; YNR073C |
GeneIDi | 855810 856639 |
KEGGi | sce:YEL070W sce:YNR073C |
Organism-specific databases
SGDi | S000000796, DSF1 |
VEuPathDBi | FungiDB:YEL070W FungiDB:YNR073C |
Phylogenomic databases
eggNOGi | ENOG502QT30, Eukaryota |
HOGENOMi | CLU_027324_0_1_1 |
InParanoidi | P0CX08 |
OMAi | YKPYDNL |
Miscellaneous databases
PROi | PR:P0CX08 |
RNActi | P0CX08, protein |
Gene expression databases
ExpressionAtlasi | P0CX08, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR000669, Mannitol_DH IPR013118, Mannitol_DH_C IPR023027, Mannitol_DH_CS IPR013131, Mannitol_DH_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01232, Mannitol_dh, 1 hit PF08125, Mannitol_dh_C, 1 hit |
PRINTSi | PR00084, MTLDHDRGNASE |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00974, MANNITOL_DHGENASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DSF1_YEAST | |
Accessioni | P0CX08Primary (citable) accession number: P0CX08 Secondary accession number(s): D3DLI1, P39941 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - SIMILARITY comments
Index of protein domains and families