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UniProtKB - P0CX08 (DSF1_YEAST)

Entry version 68 (25 May 2022)
Sequence version 1 (28 Jun 2011)
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Protein

Mannitol dehydrogenase DSF1

Gene

DSF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.

1 Publication

Miscellaneous

There are two genes for this mannitol dehydrogenase in yeast, DSF1 and YNR073C.
Present with 125 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.9 mM for mannitol1 Publication
  2. KM=869.6 mM for sorbitol1 Publication
  1. Vmax=0.1 µmol/min/mg enzyme toward mannitol1 Publication
  2. Vmax=1.5 µmol/min/mg enzyme toward sorbitol1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannitol dehydrogenase DSF11 Publication (EC:1.1.1.671 Publication)
Alternative name(s):
Deletion suppressor of MPT5 mutation protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSF11 Publication
Synonyms:MAN11 Publication
Ordered Locus Names:YEL070W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000000796, DSF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YEL070W
FungiDB:YNR073C

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Rescues temperature-sensitivity of MPT5 deletion.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001707511 – 502Mannitol dehydrogenase DSF1Add BLAST502

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0CX08

PRoteomics IDEntifications database

More...PRIDEi		P0CX08

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P0CX08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P0CX08, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35899, 81 interactors
36661, 56 interactors

STRING: functional protein association networks

More...STRINGi		4932.YEL070W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P0CX08, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P0CX08

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0CX08

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT30, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027324_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0CX08

Identification of Orthologs from Complete Genome Data

More...OMAi		YKPYDNL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008927, 6-PGluconate_DH-like_C_sf
IPR013328, 6PGD_dom2
IPR000669, Mannitol_DH
IPR013118, Mannitol_DH_C
IPR023027, Mannitol_DH_CS
IPR013131, Mannitol_DH_N
IPR036291, NAD(P)-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01232, Mannitol_dh, 1 hit
PF08125, Mannitol_dh_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00084, MTLDHDRGNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48179, SSF48179, 1 hit
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00974, MANNITOL_DHGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CX08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKSDETTAT SLNAKTLKSF ESTLPIPTYP REGVKQGIVH LGVGAFHRSH 
        60         70         80         90        100
LAVFMHRLMQ EHHLKDWSIC GVGLMKADAL MRDAMKAQDC LYTLVERGIK 
       110        120        130        140        150
DTNAYIVGSI TAYMYAPDDP RAVIEKMANP DTHIVSLTVT ENGYYHSEAT 
       160        170        180        190        200
NSLMTDAPEI INDLNHPEKP DTLYGYLYEA LLLRYKRGLT PFTIMSCDNM 
       210        220        230        240        250
PQNGVTVKTM LVAFAKLKKD EKFAAWIEDK VTSPNSMVDR VTPRCTDKER 
       260        270        280        290        300
KYVADTWGIK DQCPVVAEPF IQWVLEDNFS DGRPPWELVG VQVVKDVDSY 
       310        320        330        340        350
ELMKLRLLNG GHSAMGYLGY LAGYTYIHEV VNDPTINKYI RVLMREEVIP 
       360        370        380        390        400
LLPKVPGVDF EEYTASVLER FSNPAIQDTV ARICLMGSGK MPKYVLPSIY 
       410        420        430        440        450
EQLRKPDGKY KLLAVCVAGW FRYLTGVDMN GKPFEIEDPM APTLKAAAVK 
       460        470        480        490        500
GGKDPHELLN IEVLFSPEIR DNKEFVAQLT HSLETVYDKG PIAAIKEILD 

QV
Length:502
Mass (Da):56,470
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7E0CC01AADC1B2A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18795 Genomic DNA Translation: AAB65017.1
BK006939 Genomic DNA Translation: DAA07585.1

Protein sequence database of the Protein Information Resource

More...PIRi		S50519

NCBI Reference Sequences

More...RefSeqi		NP_010844.1, NM_001178885.1
NP_014471.3, NM_001183250.3

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YEL070W_mRNA; YEL070W; YEL070W
YNR073C_mRNA; YNR073C; YNR073C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855810
856639

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YEL070W
sce:YNR073C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18795 Genomic DNA Translation: AAB65017.1
BK006939 Genomic DNA Translation: DAA07585.1
PIRiS50519
RefSeqiNP_010844.1, NM_001178885.1
NP_014471.3, NM_001183250.3

3D structure databases

AlphaFoldDBiP0CX08
SMRiP0CX08
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35899, 81 interactors
36661, 56 interactors
STRINGi4932.YEL070W

Proteomic databases

PaxDbiP0CX08
PRIDEiP0CX08
TopDownProteomicsiP0CX08

Genome annotation databases

EnsemblFungiiYEL070W_mRNA; YEL070W; YEL070W
YNR073C_mRNA; YNR073C; YNR073C
GeneIDi855810
856639
KEGGisce:YEL070W
sce:YNR073C

Organism-specific databases

SGDiS000000796, DSF1
VEuPathDBiFungiDB:YEL070W
FungiDB:YNR073C

Phylogenomic databases

eggNOGiENOG502QT30, Eukaryota
HOGENOMiCLU_027324_0_1_1
InParanoidiP0CX08
OMAiYKPYDNL

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0CX08
RNActiP0CX08, protein

Gene expression databases

ExpressionAtlasiP0CX08, baseline and differential

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927, 6-PGluconate_DH-like_C_sf
IPR013328, 6PGD_dom2
IPR000669, Mannitol_DH
IPR013118, Mannitol_DH_C
IPR023027, Mannitol_DH_CS
IPR013131, Mannitol_DH_N
IPR036291, NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01232, Mannitol_dh, 1 hit
PF08125, Mannitol_dh_C, 1 hit
PRINTSiPR00084, MTLDHDRGNASE
SUPFAMiSSF48179, SSF48179, 1 hit
SSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00974, MANNITOL_DHGENASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSF1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CX08
Secondary accession number(s): D3DLI1, P39941
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 25, 2022
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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