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Protein

Superoxide dismutase [Cu-Zn] 1

Gene

sodC1

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Miscellaneous

Encoded by a cryptic bacteriophage.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationNote: Binds 1 copper ion per subunit.
  • Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Copper; catalytic1
Metal bindingi71Copper; catalytic1
Metal bindingi94Copper; catalytic1
Metal bindingi94Zinc; structural1
Metal bindingi103Zinc; structural1
Metal bindingi112Zinc; structural1
Metal bindingi115Zinc; structural1
Metal bindingi150Copper; catalytic1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • identical protein binding Source: IntAct
  • superoxide dismutase activity Source: GO_Central
  • zinc ion binding Source: GO_Central

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1055-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 1 (EC:1.15.1.1)
Alternative name(s):
sodCI
Gene namesi
Name:sodC1
Synonyms:sodC
Ordered Locus Names:STM1044
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003282621 – 177Superoxide dismutase [Cu-Zn] 1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 172

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0CW86

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-6399836,EBI-6399836

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

STRINGi99287.STM1044

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 31Combined sources9
Beta strandi33 – 48Combined sources16
Beta strandi51 – 58Combined sources8
Beta strandi63 – 66Combined sources4
Beta strandi68 – 74Combined sources7
Beta strandi79 – 81Combined sources3
Beta strandi84 – 86Combined sources3
Helixi89 – 91Combined sources3
Beta strandi119 – 121Combined sources3
Beta strandi131 – 133Combined sources3
Helixi139 – 142Combined sources4
Beta strandi145 – 152Combined sources8
Beta strandi156 – 162Combined sources7
Helixi163 – 165Combined sources3
Beta strandi168 – 175Combined sources8

3D structure databases

ProteinModelPortaliP0CW86
SMRiP0CW86
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CW86

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108Z7T Bacteria
COG2032 LUCA
HOGENOMiHOG000263449
OMAiSIGKIMI
PhylomeDBiP0CW86

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CW86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTILSLVA GALISCSAMA ENTLTVKMND ALSSGTGENI GEITVSETPY
60 70 80 90 100
GLLFTPHLNG LTPGIHGFHV HTNPSCMPGM KDGKEVPALM AGGHLDPEKT
110 120 130 140 150
GKHLGPYNDK GHLGDLPGLV VNADGTATYP LLAPRLKSLS ELKGHSLMIH
160 170
KGGDNYSDKP APLGGGGARF ACGVIEK
Length:177
Mass (Da):18,370
Last modified:May 31, 2011 - v1
Checksum:i1EC743EE2AB38CAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49P → T in AAB62385 (PubMed:11677609).Curated1
Sequence conflicti148M → T in AAB62385 (PubMed:11677609).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007380 Genomic DNA Translation: AAB62385.1
AE006468 Genomic DNA Translation: AAL19978.1
RefSeqiWP_000877926.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19978; AAL19978; STM1044
PATRICifig|99287.12.peg.1105

Similar proteinsi

Entry informationi

Entry nameiSODC1_SALTY
AccessioniPrimary (citable) accession number: P0CW86
Secondary accession number(s): O33803, O50545, P53636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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