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Protein

Probable C-mannosyltransferase DPY19L2

Gene

Dpy19l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mannosyltransferase activity Source: GO_Central

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan Source: GO_Central
  • spermatid development Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Transferase
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L2 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 2
Protein dpy-19 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dpy19l2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444662 Dpy19l2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei345 – 367HelicalSequence analysisAdd BLAST23
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004083271 – 773Probable C-mannosyltransferase DPY19L2Add BLAST773

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P0CW70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CW70

PeptideAtlas

More...
PeptideAtlasi
P0CW70

PRoteomics IDEntifications database

More...
PRIDEi
P0CW70

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CW70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0CW70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in testis. Present in testis but absent from epididymal sperm (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000085576 Expressed in 21 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0CW70 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000132092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P0CW70

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4587 Eukaryota
ENOG410XRWN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063023

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CW70

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSMYRVL

Database of Orthologous Groups

More...
OrthoDBi
1115173at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CW70

TreeFam database of animal gene trees

More...
TreeFami
TF313376

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030042 DPY19L2

The PANTHER Classification System

More...
PANTHERi
PTHR31488 PTHR31488, 1 hit
PTHR31488:SF6 PTHR31488:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10034 Dpy19, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CW70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGPTRSKLR EGSSDRPQSS CTGQARRRWS AATMEPQQER SAPQERTKWS
60 70 80 90 100
LLQHFLLGGR KLPSGARNYA ARRIQSLNAQ NYFQLEEVAK LLLLNRFQFL
110 120 130 140 150
FTLLDHFREK VQALQMHRFS HRTLFGLAIF VGILHWLHLI TLFENDHHFS
160 170 180 190 200
HLSSLEREMT FRTEMGLYYS YFKTIIEAPS FLEGLWMIMN DRLTEYPLVI
210 220 230 240 250
NTVKRFHLYP EVVIAYWYRT IIGIMNLFGI ETKTCWNVTR MEPLNEVQSC
260 270 280 290 300
EGLGDPACFY IGVIFILNGL MMGLFFIYST YLSGSQLGGL ITVACYFFNH
310 320 330 340 350
GEATRVMWTP PLRESFSYPF LVLQMYILTI ILRTSTVHKK HYMALCFSNV
360 370 380 390 400
AFMLPWQFAQ FILFTQIASL FPMYVVGYIE PSKFQKIIYV NMSSVALCFI
410 420 430 440 450
LMFGNSMYLS SYYSSCLLVT WAIMQKKSKI QKLGGTELQF WLIQGCFWWC
460 470 480 490 500
GTIILKFLTS KICGVSDHIR LSDLIAARIL RYTDFDTLIY TCAPEFDFME
510 520 530 540 550
QATPLRYIKT LLLPLILVIT YLIFKKIVRD IMCVLYTNTY VRKQLLDNAE
560 570 580 590 600
LIFHTLQLLA FTGLAILIMR LKLFLTPHMC IMASLICSQR LFGWLFCRIH
610 620 630 640 650
FENVVFGILT MMSIQGCANL HNQWSIMGEF TNLPQEELIH WIKHSTRPDA
660 670 680 690 700
VFAGAMPTMA SIKLSTLRPI VNHPHYEDAD LRARTKIVYS VYSRKSAVEV
710 720 730 740 750
RNNLLKLHVN YYVLEEAWCV VRTKPGCSML EIWDVEDPSN AANPPLCSIL
760 770
LKDSRPYFTT VFQNSMYRVL KIN
Length:773
Mass (Da):89,882
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72BE45D2458E68C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC154463 Genomic DNA No translation available.
CT025664 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52743.1

NCBI Reference Sequences

More...
RefSeqi
NP_001159679.1, NM_001166207.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.46158

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320752

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:320752

UCSC genome browser

More...
UCSCi
uc009opc.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154463 Genomic DNA No translation available.
CT025664 Genomic DNA No translation available.
CCDSiCCDS52743.1
RefSeqiNP_001159679.1, NM_001166207.1
UniGeneiMm.46158

3D structure databases

ProteinModelPortaliP0CW70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132092

PTM databases

iPTMnetiP0CW70
PhosphoSitePlusiP0CW70

Proteomic databases

MaxQBiP0CW70
PaxDbiP0CW70
PeptideAtlasiP0CW70
PRIDEiP0CW70

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576
GeneIDi320752
KEGGimmu:320752
UCSCiuc009opc.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283417
MGIiMGI:2444662 Dpy19l2

Phylogenomic databases

eggNOGiKOG4587 Eukaryota
ENOG410XRWN LUCA
GeneTreeiENSGT00530000063023
InParanoidiP0CW70
OMAiNSMYRVL
OrthoDBi1115173at2759
PhylomeDBiP0CW70
TreeFamiTF313376

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CW70

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000085576 Expressed in 21 organ(s), highest expression level in testis
GenevisibleiP0CW70 MM

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030042 DPY19L2
PANTHERiPTHR31488 PTHR31488, 1 hit
PTHR31488:SF6 PTHR31488:SF6, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD19L2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CW70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: January 16, 2019
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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