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Protein

Probable C-mannosyltransferase DPY19L2

Gene

Dpy19l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity).By similarity

GO - Molecular functioni

  • mannosyltransferase activity Source: GO_Central

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan Source: GO_Central
  • spermatid development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Transferase
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L2 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 2
Protein dpy-19 homolog 2
Gene namesi
Name:Dpy19l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444662 Dpy19l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei345 – 367HelicalSequence analysisAdd BLAST23
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004083271 – 773Probable C-mannosyltransferase DPY19L2Add BLAST773

Proteomic databases

MaxQBiP0CW70
PaxDbiP0CW70
PeptideAtlasiP0CW70
PRIDEiP0CW70

PTM databases

iPTMnetiP0CW70
PhosphoSitePlusiP0CW70

Expressioni

Tissue specificityi

Predominantly expressed in testis. Present in testis but absent from epididymal sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000085576 Expressed in 21 organ(s), highest expression level in testis
GenevisibleiP0CW70 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132092

Structurei

3D structure databases

ProteinModelPortaliP0CW70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4587 Eukaryota
ENOG410XRWN LUCA
GeneTreeiENSGT00530000063023
InParanoidiP0CW70
OMAiNSMYRVL
OrthoDBiEOG091G02PL
PhylomeDBiP0CW70
TreeFamiTF313376

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030042 DPY19L2
PANTHERiPTHR31488 PTHR31488, 1 hit
PTHR31488:SF6 PTHR31488:SF6, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit

Sequencei

Sequence statusi: Complete.

P0CW70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGPTRSKLR EGSSDRPQSS CTGQARRRWS AATMEPQQER SAPQERTKWS
60 70 80 90 100
LLQHFLLGGR KLPSGARNYA ARRIQSLNAQ NYFQLEEVAK LLLLNRFQFL
110 120 130 140 150
FTLLDHFREK VQALQMHRFS HRTLFGLAIF VGILHWLHLI TLFENDHHFS
160 170 180 190 200
HLSSLEREMT FRTEMGLYYS YFKTIIEAPS FLEGLWMIMN DRLTEYPLVI
210 220 230 240 250
NTVKRFHLYP EVVIAYWYRT IIGIMNLFGI ETKTCWNVTR MEPLNEVQSC
260 270 280 290 300
EGLGDPACFY IGVIFILNGL MMGLFFIYST YLSGSQLGGL ITVACYFFNH
310 320 330 340 350
GEATRVMWTP PLRESFSYPF LVLQMYILTI ILRTSTVHKK HYMALCFSNV
360 370 380 390 400
AFMLPWQFAQ FILFTQIASL FPMYVVGYIE PSKFQKIIYV NMSSVALCFI
410 420 430 440 450
LMFGNSMYLS SYYSSCLLVT WAIMQKKSKI QKLGGTELQF WLIQGCFWWC
460 470 480 490 500
GTIILKFLTS KICGVSDHIR LSDLIAARIL RYTDFDTLIY TCAPEFDFME
510 520 530 540 550
QATPLRYIKT LLLPLILVIT YLIFKKIVRD IMCVLYTNTY VRKQLLDNAE
560 570 580 590 600
LIFHTLQLLA FTGLAILIMR LKLFLTPHMC IMASLICSQR LFGWLFCRIH
610 620 630 640 650
FENVVFGILT MMSIQGCANL HNQWSIMGEF TNLPQEELIH WIKHSTRPDA
660 670 680 690 700
VFAGAMPTMA SIKLSTLRPI VNHPHYEDAD LRARTKIVYS VYSRKSAVEV
710 720 730 740 750
RNNLLKLHVN YYVLEEAWCV VRTKPGCSML EIWDVEDPSN AANPPLCSIL
760 770
LKDSRPYFTT VFQNSMYRVL KIN
Length:773
Mass (Da):89,882
Last modified:May 3, 2011 - v1
Checksum:i72BE45D2458E68C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154463 Genomic DNA No translation available.
CT025664 Genomic DNA No translation available.
CCDSiCCDS52743.1
RefSeqiNP_001159679.1, NM_001166207.1
UniGeneiMm.46158

Genome annotation databases

EnsembliENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576
GeneIDi320752
KEGGimmu:320752
UCSCiuc009opc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154463 Genomic DNA No translation available.
CT025664 Genomic DNA No translation available.
CCDSiCCDS52743.1
RefSeqiNP_001159679.1, NM_001166207.1
UniGeneiMm.46158

3D structure databases

ProteinModelPortaliP0CW70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132092

PTM databases

iPTMnetiP0CW70
PhosphoSitePlusiP0CW70

Proteomic databases

MaxQBiP0CW70
PaxDbiP0CW70
PeptideAtlasiP0CW70
PRIDEiP0CW70

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576
GeneIDi320752
KEGGimmu:320752
UCSCiuc009opc.2 mouse

Organism-specific databases

CTDi283417
MGIiMGI:2444662 Dpy19l2

Phylogenomic databases

eggNOGiKOG4587 Eukaryota
ENOG410XRWN LUCA
GeneTreeiENSGT00530000063023
InParanoidiP0CW70
OMAiNSMYRVL
OrthoDBiEOG091G02PL
PhylomeDBiP0CW70
TreeFamiTF313376

Miscellaneous databases

PROiPR:P0CW70
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000085576 Expressed in 21 organ(s), highest expression level in testis
GenevisibleiP0CW70 MM

Family and domain databases

InterProiView protein in InterPro
IPR018732 Dpy-19/Dpy-19-like
IPR030042 DPY19L2
PANTHERiPTHR31488 PTHR31488, 1 hit
PTHR31488:SF6 PTHR31488:SF6, 1 hit
PfamiView protein in Pfam
PF10034 Dpy19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD19L2_MOUSE
AccessioniPrimary (citable) accession number: P0CW70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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