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Protein

Coiled-coil domain-containing protein 166

Gene

CCDC166

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 166
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC166
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000255181.3

Human Gene Nomenclature Database

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HGNCi
HGNC:41910 CCDC166

neXtProt; the human protein knowledge platform

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neXtProti
NX_P0CW27

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000255181

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC166

Domain mapping of disease mutations (DMDM)

More...
DMDMi
347602472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004122241 – 439Coiled-coil domain-containing protein 166Add BLAST439

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P0CW27

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P0CW27

PeptideAtlas

More...
PeptideAtlasi
P0CW27

PRoteomics IDEntifications database

More...
PRIDEi
P0CW27

ProteomicsDB human proteome resource

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ProteomicsDBi
52525

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CW27

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P0CW27

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255181 Expressed in 5 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

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HPAi
HPA025058

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000437468

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0CW27

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0CW27

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili27 – 74Sequence analysisAdd BLAST48
Coiled coili121 – 213Sequence analysisAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi288 – 410Ser-richAdd BLAST123

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWCJ Eukaryota
ENOG4111HGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154427

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CW27

Identification of Orthologs from Complete Genome Data

More...
OMAi
HREHEDT

Database of Orthologous Groups

More...
OrthoDBi
997189at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CW27

TreeFam database of animal gene trees

More...
TreeFami
TF343581

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029584 CCDC166
IPR032777 DUF4515

The PANTHER Classification System

More...
PANTHERi
PTHR14845:SF4 PTHR14845:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14988 DUF4515, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CW27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKKKRGPS AGSQPGGAAA AGAEQPLSER AQYLQREHAL LSEQLDTCEE
60 70 80 90 100
SVDQVLRENA FLDREALRLR EENRLYASYV SARAQRCAKA IVRLDEQNRV
110 120 130 140 150
DLAQIHWQRA ELASLYHGRE DGVRAQLLEM EARAAQMAQQ VQELQPYKVL
160 170 180 190 200
QLEQLARIRA LERELLHMRV EHTQLLHRVK RRFLEDKAAF EREARQRVQS
210 220 230 240 250
LARRAEREAV RALVAHTQAI KADNGRLRQE LLLLLRRTQL LHHTRRQLLE
260 270 280 290 300
QREQLHREHE DTRDLARVHG WLRRGPGGPP LWERPAFSQP TSRPGSLAAP
310 320 330 340 350
ISPSRAASQT PSVVPSRAAP RASSVVPSRE ASRVPSLVLS SMDSRVPSLA
360 370 380 390 400
TSKVGSRMPS LTASRAGSRA LSLVQSLEGS GISSGSSPRV SSQDTLRSTK
410 420 430
SGPKLLSGLS RDRDPALLPP QSEDSVNAEA AAEASPGRA
Length:439
Mass (Da):48,709
Last modified:September 21, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6394873C2985C8A4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC105219 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS55280.1

NCBI Reference Sequences

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RefSeqi
NP_001156386.1, NM_001162914.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.730002

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000533508; ENSP00000437315; ENSG00000278749
ENST00000542437; ENSP00000437468; ENSG00000255181

Database of genes from NCBI RefSeq genomes

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GeneIDi
100130274

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:100130274

UCSC genome browser

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UCSCi
uc011lkr.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105219 Genomic DNA No translation available.
CCDSiCCDS55280.1
RefSeqiNP_001156386.1, NM_001162914.1
UniGeneiHs.730002

3D structure databases

ProteinModelPortaliP0CW27
SMRiP0CW27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000437468

PTM databases

iPTMnetiP0CW27
PhosphoSitePlusiP0CW27

Polymorphism and mutation databases

BioMutaiCCDC166
DMDMi347602472

Proteomic databases

jPOSTiP0CW27
PaxDbiP0CW27
PeptideAtlasiP0CW27
PRIDEiP0CW27
ProteomicsDBi52525

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533508; ENSP00000437315; ENSG00000278749
ENST00000542437; ENSP00000437468; ENSG00000255181
GeneIDi100130274
KEGGihsa:100130274
UCSCiuc011lkr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100130274
EuPathDBiHostDB:ENSG00000255181.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC166
HGNCiHGNC:41910 CCDC166
HPAiHPA025058
neXtProtiNX_P0CW27
OpenTargetsiENSG00000255181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWCJ Eukaryota
ENOG4111HGH LUCA
GeneTreeiENSGT00940000154427
InParanoidiP0CW27
OMAiHREHEDT
OrthoDBi997189at2759
PhylomeDBiP0CW27
TreeFamiTF343581

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CW27

Gene expression databases

BgeeiENSG00000255181 Expressed in 5 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR029584 CCDC166
IPR032777 DUF4515
PANTHERiPTHR14845:SF4 PTHR14845:SF4, 1 hit
PfamiView protein in Pfam
PF14988 DUF4515, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC166_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CW27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: January 16, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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