UniProtKB - P0CW02 (LY6C1_MOUSE)
Protein
Lymphocyte antigen 6C1
Gene
Ly6c1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- acetylcholine receptor binding Source: GO_Central
- acetylcholine receptor inhibitor activity Source: GO_Central
GO - Biological processi
- acetylcholine receptor signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Lymphocyte antigen 6C1Short name: Ly-6C1 |
Gene namesi | Name:Ly6c1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96882, Ly6c1 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; GPI-anchor Curated
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: GO_Central
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: MGI
- synapse Source: GOC
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000408033 | 27 – 109 | Lymphocyte antigen 6C1Add BLAST | 83 | |
PropeptideiPRO_0000408034 | 110 – 131 | Removed in mature formSequence analysisAdd BLAST | 22 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 53 | By similarity | ||
Disulfide bondi | 32 ↔ 41 | By similarity | ||
Disulfide bondi | 46 ↔ 74 | By similarity | ||
Disulfide bondi | 78 ↔ 95 | By similarity | ||
Disulfide bondi | 96 ↔ 101 | By similarity | ||
Lipidationi | 109 | GPI-anchor amidated glycineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P0CW02 |
MaxQBi | P0CW02 |
PaxDbi | P0CW02 |
PeptideAtlasi | P0CW02 |
PRIDEi | P0CW02 |
ProteomicsDBi | 291971 |
PTM databases
SwissPalmi | P0CW02 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000079018, Expressed in muscle tissue and 59 other tissues |
ExpressionAtlasi | P0CW02, baseline and differential |
Genevisiblei | P0CW02, MM |
Interactioni
GO - Molecular functioni
- acetylcholine receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000066954 |
Miscellaneous databases
RNActi | P0CW02, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 115 | UPAR/Ly6Add BLAST | 89 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TD4F, Eukaryota |
GeneTreei | ENSGT00940000154560 |
HOGENOMi | CLU_106772_0_0_1 |
InParanoidi | P0CW02 |
PhylomeDBi | P0CW02 |
TreeFami | TF337757 |
Family and domain databases
CDDi | cd00117, LU, 1 hit |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 1 hit |
SMARTi | View protein in SMART SM00134, LU, 1 hit |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P0CW02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTSHTTKSC VLILLVALLC AERAQGLQCY ECYGVPIETS CPAVTCRASD
60 70 80 90 100
GFCIAQNIEL IEDSQRRKLK TRQCLSFCPA GVPIRDPNIR ERTSCCSEDL
110 120 130
CNAAVPTAGS TWTMAGVLLF SLSSVVLQTL L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WNZ5 | A0A087WNZ5_MOUSE | Lymphocyte antigen 6C1 | Ly6c1 | 147 | Annotation score: | ||
A0A087WRG9 | A0A087WRG9_MOUSE | Lymphocyte antigen 6C1 | Ly6c1 | 81 | Annotation score: | ||
A0A087WRP7 | A0A087WRP7_MOUSE | Lymphocyte antigen 6C1 | Ly6c1 | 111 | Annotation score: | ||
A0A087WPW7 | A0A087WPW7_MOUSE | Lymphocyte antigen 6C1 | Ly6c1 | 78 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 – 4 | TS → ST in AAA39469 (PubMed:3356904).Curated | 2 | |
Sequence conflicti | 6 | T → A in AAA39469 (PubMed:3356904).Curated | 1 | |
Sequence conflicti | 11 | V → L in AAA39469 (PubMed:3356904).Curated | 1 | |
Sequence conflicti | 22 | E → G in AAA39469 (PubMed:3356904).Curated | 1 | |
Sequence conflicti | 22 | E → G in BAC40570 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21734, M21771, M21733 Genomic DNA Translation: AAA39469.1 AK088782 mRNA Translation: BAC40570.1 AK143577 mRNA Translation: BAE25446.1 BC010764 mRNA Translation: AAH10764.1 |
CCDSi | CCDS27541.1 |
RefSeqi | NP_001238984.1, NM_001252055.1 NP_034871.2, NM_010741.3 XP_006520584.1, XM_006520521.3 |
Genome annotation databases
Ensembli | ENSMUST00000065408; ENSMUSP00000066954; ENSMUSG00000079018 ENSMUST00000179762; ENSMUSP00000137401; ENSMUSG00000079018 ENSMUST00000187347; ENSMUSP00000139799; ENSMUSG00000079018 |
GeneIDi | 17067 |
KEGGi | mmu:17067 |
UCSCi | uc007wgn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21734, M21771, M21733 Genomic DNA Translation: AAA39469.1 AK088782 mRNA Translation: BAC40570.1 AK143577 mRNA Translation: BAE25446.1 BC010764 mRNA Translation: AAH10764.1 |
CCDSi | CCDS27541.1 |
RefSeqi | NP_001238984.1, NM_001252055.1 NP_034871.2, NM_010741.3 XP_006520584.1, XM_006520521.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000066954 |
PTM databases
SwissPalmi | P0CW02 |
Proteomic databases
jPOSTi | P0CW02 |
MaxQBi | P0CW02 |
PaxDbi | P0CW02 |
PeptideAtlasi | P0CW02 |
PRIDEi | P0CW02 |
ProteomicsDBi | 291971 |
Genome annotation databases
Ensembli | ENSMUST00000065408; ENSMUSP00000066954; ENSMUSG00000079018 ENSMUST00000179762; ENSMUSP00000137401; ENSMUSG00000079018 ENSMUST00000187347; ENSMUSP00000139799; ENSMUSG00000079018 |
GeneIDi | 17067 |
KEGGi | mmu:17067 |
UCSCi | uc007wgn.2, mouse |
Organism-specific databases
CTDi | 17067 |
MGIi | MGI:96882, Ly6c1 |
Phylogenomic databases
eggNOGi | ENOG502TD4F, Eukaryota |
GeneTreei | ENSGT00940000154560 |
HOGENOMi | CLU_106772_0_0_1 |
InParanoidi | P0CW02 |
PhylomeDBi | P0CW02 |
TreeFami | TF337757 |
Miscellaneous databases
BioGRID-ORCSi | 17067, 3 hits in 22 CRISPR screens |
ChiTaRSi | Ly6c1, mouse |
PROi | PR:P0CW02 |
RNActi | P0CW02, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079018, Expressed in muscle tissue and 59 other tissues |
ExpressionAtlasi | P0CW02, baseline and differential |
Genevisiblei | P0CW02, MM |
Family and domain databases
CDDi | cd00117, LU, 1 hit |
InterProi | View protein in InterPro IPR018363, CD59_antigen_CS IPR016054, LY6_UPA_recep-like |
Pfami | View protein in Pfam PF00021, UPAR_LY6, 1 hit |
SMARTi | View protein in SMART SM00134, LU, 1 hit |
PROSITEi | View protein in PROSITE PS00983, LY6_UPAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LY6C1_MOUSE | |
Accessioni | P0CW02Primary (citable) accession number: P0CW02 Secondary accession number(s): P09568 Q91XG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 3, 2011 |
Last sequence update: | May 3, 2011 | |
Last modified: | April 7, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot