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Entry version 44 (10 Feb 2021)
Sequence version 1 (28 Jun 2011)
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Protein

Pre-mRNA-splicing factor RSE1

Gene

RSE1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing and cell cycle control.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor RSE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSE1
Ordered Locus Names:CNA04430
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri214684 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CNA04430

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002186291 – 1217Pre-mRNA-splicing factor RSE1Add BLAST1217

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CR22

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associated with the spliceosome.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5207.AAW40985

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0CR22

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RSE1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1898, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003246_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CR22

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHQNRFH

Database of Orthologous Groups

More...
OrthoDBi
97116at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CR22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLNLTLSS PTNVSTAVVG SFSGSKSQEI LCVRGGTKLE IFKLNATTGQ
60 70 80 90 100
LDTIVSTEAF GTIRNIAGFR LAGMTKDYIL ATSDSGRLSI LEFVISPTPH
110 120 130 140 150
FESLYQEVFG KSGSRRIVPG QFLAVDPKGR SCLVGSLEKT KLVYVLNRNT
160 170 180 190 200
EGKLYPSSPL EAHKNHTLVT HIVGVDQGYD NPLYAALETD YSESDQDSTG
210 220 230 240 250
EAYENTQKHL TFYELDLGLN HVVRKWSEPT DRRANLLVQV PGGQNANSDR
260 270 280 290 300
FEGPSGVLVC TEDHIIWKHM DVEAHRIPIP RRRNPLVQRG DKSRGLIIVS
310 320 330 340 350
AVMHKIKGAF FFLLQSEDGD LYKVWIEHNG EDVVALKIKY FDTVPVANSL
360 370 380 390 400
CILKRGYIYV ASEFSDQNLY QFQSLAEDDG EQEWSSTDYP ENGNIDGPLP
410 420 430 440 450
FAFFDPQPLR NLLLVDTVPS LDPITDAHVV NLLGASSDTP QIYAACGRGA
460 470 480 490 500
RSTFRTLKHG LDVAEMVSSP LPGVPTNVWT LKLTEDDEYD SYIVLSFPNG
510 520 530 540 550
TLVLSIGETI EEVNDTGFLS SGPTLAVQQL GNAGLLQVHP YGLRHIRAAD
560 570 580 590 600
RVDEWPAPPG QTIVAATTNR RQVVIALSTA ELVYFELDPE GSLSEYQEKK
610 620 630 640 650
ALPGNATCVT IAEVPEGRRR TSFLAVGCDN QTVSIISLEP DSTLDTLSLQ
660 670 680 690 700
ALTAPPTSIC LAEIFDTSID KNRATMFLNI GLMNGVLLRT VVDPVDGSLS
710 720 730 740 750
DTRLRFLGAK PPKLVRANVQ GQPSVMAFSS RTWLLYTYQD MLQTQPLIYD
760 770 780 790 800
TLEYAWSLSA AMCPDGLIGI SGNTLRIFNI PKLGEKLKQD STALTYTPRK
810 820 830 840 850
FISHPFNSVF YMIEADHRTY SKSAIERIVK QKESEGRRVD TLLLDLPANE
860 870 880 890 900
FGRPRAPAGH WASCVRVLDP LANETIMTLD LDEDEAAFSI AIAYFERGGG
910 920 930 940 950
EPFLVVGTGV KTTLQPKGCK EGYLRVYAIK EQGRILEFLH KTKTDDIPLC
960 970 980 990 1000
LAGFQGFLLA GIGKSLRLYE MGKKALLRKC ENNGFPTAVV TINVQGARII
1010 1020 1030 1040 1050
VGDMQESTFY CVYRSIPTRQ LLIFADDSQP RWITCVTSVD YETVACGDKF
1060 1070 1080 1090 1100
GNIFINRLDP SISEKVDDDP TGATILHEKS FLMGAAHKTE MIGHYNIGSV
1110 1120 1130 1140 1150
VTSITKIPLV AGGRDVLVYT TISGAVGALV PFVSSDDIEF MSTLEMHMRT
1160 1170 1180 1190 1200
QDISLVGRDH IAYRGYYVPI KGVVDGDLCE SFSLLPYPKQ QAIALDLDRS
1210
VGDVLKKLEQ MRTSSAF
Length:1,217
Mass (Da):134,097
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB110309F1EDBA73A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017341 Genomic DNA Translation: AAW40985.1

NCBI Reference Sequences

More...
RefSeqi
XP_566804.1, XM_566804.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AAW40985; AAW40985; CNA04430

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3253342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cne:CNA04430

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA Translation: AAW40985.1
RefSeqiXP_566804.1, XM_566804.1

3D structure databases

SMRiP0CR22
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5207.AAW40985

Proteomic databases

PaxDbiP0CR22

Genome annotation databases

EnsemblFungiiAAW40985; AAW40985; CNA04430
GeneIDi3253342
KEGGicne:CNA04430

Organism-specific databases

VEuPathDBiFungiDB:CNA04430

Phylogenomic databases

eggNOGiKOG1898, Eukaryota
HOGENOMiCLU_003246_0_0_1
InParanoidiP0CR22
OMAiYHQNRFH
OrthoDBi97116at2759

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSE1_CRYNJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CR22
Secondary accession number(s): Q55ZR3, Q5KP25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 10, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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