Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein arginine N-methyltransferase 2

Gene

RMT2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei265S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:RMT2By similarity
Ordered Locus Names:CNA04170
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNA04170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289731 – 363Protein arginine N-methyltransferase 2Add BLAST363

Proteomic databases

PaxDbiP0CQ68

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi214684.XP_566779.1

Structurei

3D structure databases

ProteinModelPortaliP0CQ68
SMRiP0CQ68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 46ANK 1Add BLAST25
Repeati48 – 80ANK 2Add BLAST33
Domaini111 – 363RMT2PROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 191S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni209 – 211S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni236 – 237S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG1709 Eukaryota
ENOG4110T2S LUCA
InParanoidiP0CQ68
KOiK18477
OMAiAVWNAVD
OrthoDBiEOG092C2OT7

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017408 Arginine_N-MeTrfase_2
IPR026480 RMT2_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PIRSFiPIRSF038148 Arginine_N-mtfrase-2, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS51559 SAM_RMT2, 1 hit

Sequencei

Sequence statusi: Complete.

P0CQ68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMDSAHLDS SLLTLAFRLI KAAQTAAPSV LADLLAEGAP AWFQDDDLGW
60 70 80 90 100
SCLHYAAERK EPECLEVLLQ GGAVWNAVDK WGRTAGEICL SLGDEEGWSI
110 120 130 140 150
IRNEGIRSED KTSAGDNLVF LKSKLTWDVG KDGKERVLDA DGNGVMMGWE
160 170 180 190 200
EPLSYCIVVE HVKRLTEEHP KAELGAEGMS ILNVGFGLGI VDRLFQECDP
210 220 230 240 250
KPSHHTIIEA HPQVLEYIHK KGVHLLPNVR ILQGRWQDWL LDGEKVGDVL
260 270 280 290 300
SGTPDGMGFD AIFVDTFAEG YEDLKAFFEV IPDILNADNG RFSFWNGLGA
310 320 330 340 350
TNPTIYAVSS SLAELHLEDV GLQVEWHDVL IPESMREEVW KGVRRRYWDL
360
PGYRLPIAKM SLI
Length:363
Mass (Da):40,439
Last modified:June 28, 2011 - v1
Checksum:i23A0519EA8A9E22D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA Translation: AAW40960.1
RefSeqiXP_566779.1, XM_566779.1

Genome annotation databases

KEGGicne:CNA04170

Similar proteinsi

Entry informationi

Entry nameiRMT2_CRYNJ
AccessioniPrimary (citable) accession number: P0CQ68
Secondary accession number(s): Q55ZU0, Q5KP51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health