UniProtKB - P0CP36 (NTE1_CRYNJ)
Protein
Lysophospholipase NTE1
Gene
NTE1
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Functioni
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity
Catalytic activityi
- EC:3.1.1.5
Activity regulationi
Inhibited by organophosphorus esters.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1349 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1467 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 788 – 907 | cNMP 1Add BLAST | 120 | |
Nucleotide bindingi | 951 – 1070 | cNMP 2Add BLAST | 120 |
GO - Molecular functioni
- lysophospholipase activity Source: GO_Central
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylcholine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipase NTE1 (EC:3.1.1.5)Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog |
Gene namesi | Name:NTE1 Ordered Locus Names:CND04180 |
Organismi | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
Taxonomic identifieri | 214684 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CND04180 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 34 – 59 | LumenalBy similarityAdd BLAST | 26 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 1621 | CytoplasmicBy similarityAdd BLAST | 1541 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295318 | 1 – 1621 | Lysophospholipase NTE1Add BLAST | 1621 |
Proteomic databases
PaxDbi | P0CP36 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1316 – 1480 | PNPLAPROSITE-ProRule annotationAdd BLAST | 165 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1320 – 1325 | GXGXXGPROSITE-ProRule annotation | 6 | |
Motifi | 1347 – 1351 | GXSXGPROSITE-ProRule annotation | 5 | |
Motifi | 1467 – 1469 | DGA/GPROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the NTE family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2968, Eukaryota |
InParanoidi | P0CP36 |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CP36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR
60 70 80 90 100
MLQYSLTISL GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS
110 120 130 140 150
PPALASRLLP LDGDGLGLPD SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF
160 170 180 190 200
HELSRHLQTR RLAAGDTLEI GGGEFWCVVE GKVQVFAPDA SSQGTPTPSS
210 220 230 240 250
DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK LSWKSSADDE
260 270 280 290 300
GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID
310 320 330 340 350
SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS
360 370 380 390 400
QSLRSSPRLN SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED
410 420 430 440 450
TTLAVIPAAA FRKLTRKFPK ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE
460 470 480 490 500
ILQTESSLNL LVTHPLPRSF YTGGGMQALR ARFQPEALAK ESVHYDSLKS
510 520 530 540 550
SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK SSLGQTATTT
560 570 580 590 600
VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM
610 620 630 640 650
RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL
660 670 680 690 700
NDSPHTDGQP VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD
710 720 730 740 750
MIARSSMAPS VSALSTPNSP MFPPNAGTPL QGSTRSRPPH FGNVLDLINA
760 770 780 790 800
SSQNEGVIGG MLREAAFNSR PDDEASSISM SLHDSQGGAS GVDRKIMKDL
810 820 830 840 850
ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR STSSNQENPN
860 870 880 890 900
STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG
910 920 930 940 950
GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK
960 970 980 990 1000
RLLSLLSPLV LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT
1010 1020 1030 1040 1050
EKNDNMHVLR EYGQNDSIGE LDVITAVDRS ETVHAIRDSE LVRIPAALFD
1060 1070 1080 1090 1100
AISIKHPETT VQFMRLIAGR VRRALGDEMN GRVPGLPTTD MNLKTVCVLG
1110 1120 1130 1140 1150
STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH AFARIGKLKV
1160 1170 1180 1190 1200
AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE
1210 1220 1230 1240 1250
YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG
1260 1270 1280 1290 1300
VVTPARPIPP VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN
1310 1320 1330 1340 1350
DFARIARRLC GQQIGLVLGG GGARGISHIG MLQALEEFGI PIDAIGGCSI
1360 1370 1380 1390 1400
GSFVGGLYAR ETDLLETAGR TKQFSGRMGS MWRILSDVTY PFVSYTTGHE
1410 1420 1430 1440 1450
FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY AWRYVRASMT
1460 1470 1480 1490 1500
LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP
1510 1520 1530 1540 1550
RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT
1560 1570 1580 1590 1600
PGCHYIAMPV QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL
1610 1620
VDEAKGSKAV QRGNRLRRMS I
Sequence cautioni
The sequence AAW42828 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017344 Genomic DNA Translation: AAW42828.1 Sequence problems. |
RefSeqi | XP_570135.1, XM_570135.1 |
Genome annotation databases
EnsemblFungii | AAW42828; AAW42828; CND04180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017344 Genomic DNA Translation: AAW42828.1 Sequence problems. |
RefSeqi | XP_570135.1, XM_570135.1 |
3D structure databases
SMRi | P0CP36 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5207.AAW42828 |
Proteomic databases
PaxDbi | P0CP36 |
Genome annotation databases
EnsemblFungii | AAW42828; AAW42828; CND04180 |
Organism-specific databases
VEuPathDBi | FungiDB:CND04180 |
Phylogenomic databases
eggNOGi | KOG2968, Eukaryota |
InParanoidi | P0CP36 |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTE1_CRYNJ | |
Accessioni | P0CP36Primary (citable) accession number: P0CP36 Secondary accession number(s): Q55U92, Q5KI53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 10, 2021 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families