NTE1

Functionⁱ

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityⁱ

2-lysophosphatidylcholine + H₂O = glycerophosphocholine + a carboxylate.

Activity regulationⁱ

Inhibited by organophosphorus esters.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	1349	NucleophilePROSITE-ProRule annotation		1
Active siteⁱ	1467	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	788 – 907	cNMP 1Add BLAST		120
Nucleotide bindingⁱ	951 – 1070	cNMP 2Add BLAST		120

GO - Molecular functionⁱ

lysophospholipase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid catabolic process Source: UniProtKB-KW
phosphatidylcholine metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid degradation, Lipid metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysophospholipase NTE1 (EC:3.1.1.5) Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog
Gene namesⁱ	Name:NTE1 Ordered Locus Names:CND04180
Organismⁱ	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifierⁱ	214684 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex › Cryptococcus neoformans › Cryptococcus neoformans var. neoformans
Proteomesⁱ	UP000002149 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	FungiDB:CND04180

EuPathDBⁱ

FungiDB:CND04180

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 12	CytoplasmicBy similarityAdd BLAST	12
Transmembraneⁱ	13 – 33	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	34 – 59	LumenalBy similarityAdd BLAST	26
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 1621	CytoplasmicBy similarityAdd BLAST	1541

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000295318	1 – 1621	Lysophospholipase NTE1Add BLAST		1621

Proteomic databases

PaxDbⁱ	P0CP36

PaxDbⁱ

P0CP36

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	214684.XP_570135.1

STRINGⁱ

214684.XP_570135.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0CP36
SMRⁱ	P0CP36
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1316 – 1480	PNPLAPROSITE-ProRule annotationAdd BLAST		165

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	1320 – 1325	GXGXXGPROSITE-ProRule annotation	6
Motifⁱ	1347 – 1351	GXSXGPROSITE-ProRule annotation	5
Motifⁱ	1467 – 1469	DGA/GPROSITE-ProRule annotation	3

Sequence similaritiesⁱ

Belongs to the NTE family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2968 Eukaryota COG0664 LUCA COG1752 LUCA
InParanoidⁱ	P0CP36
KEGG Orthology (KO) More...KOⁱ	K14676
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0BAH

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00038 CAP_ED, 2 hits
Gene3Dⁱ	2.60.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR001423 LysoPLipase_patatin_CS IPR002641 PNPLA_dom IPR014710 RmlC-like_jellyroll
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 1 hit PF01734 Patatin, 1 hit
SMARTⁱ	View protein in SMART SM00100 cNMP, 2 hits
SUPFAMⁱ	SSF51206 SSF51206, 3 hits SSF52151 SSF52151, 1 hit
PROSITEⁱ	View protein in PROSITE PS50042 CNMP_BINDING_3, 2 hits PS51635 PNPLA, 1 hit PS01237 UPF0028, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0CP36-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR 
        60         70         80         90        100
MLQYSLTISL GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS 
       110        120        130        140        150
PPALASRLLP LDGDGLGLPD SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF 
       160        170        180        190        200
HELSRHLQTR RLAAGDTLEI GGGEFWCVVE GKVQVFAPDA SSQGTPTPSS 
       210        220        230        240        250
DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK LSWKSSADDE 
       260        270        280        290        300
GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID 
       310        320        330        340        350
SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS 
       360        370        380        390        400
QSLRSSPRLN SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED 
       410        420        430        440        450
TTLAVIPAAA FRKLTRKFPK ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE 
       460        470        480        490        500
ILQTESSLNL LVTHPLPRSF YTGGGMQALR ARFQPEALAK ESVHYDSLKS 
       510        520        530        540        550
SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK SSLGQTATTT 
       560        570        580        590        600
VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM 
       610        620        630        640        650
RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL 
       660        670        680        690        700
NDSPHTDGQP VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD 
       710        720        730        740        750
MIARSSMAPS VSALSTPNSP MFPPNAGTPL QGSTRSRPPH FGNVLDLINA 
       760        770        780        790        800
SSQNEGVIGG MLREAAFNSR PDDEASSISM SLHDSQGGAS GVDRKIMKDL 
       810        820        830        840        850
ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR STSSNQENPN 
       860        870        880        890        900
STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG 
       910        920        930        940        950
GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK 
       960        970        980        990       1000
RLLSLLSPLV LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT 
      1010       1020       1030       1040       1050
EKNDNMHVLR EYGQNDSIGE LDVITAVDRS ETVHAIRDSE LVRIPAALFD 
      1060       1070       1080       1090       1100
AISIKHPETT VQFMRLIAGR VRRALGDEMN GRVPGLPTTD MNLKTVCVLG 
      1110       1120       1130       1140       1150
STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH AFARIGKLKV 
      1160       1170       1180       1190       1200
AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE 
      1210       1220       1230       1240       1250
YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG 
      1260       1270       1280       1290       1300
VVTPARPIPP VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN 
      1310       1320       1330       1340       1350
DFARIARRLC GQQIGLVLGG GGARGISHIG MLQALEEFGI PIDAIGGCSI 
      1360       1370       1380       1390       1400
GSFVGGLYAR ETDLLETAGR TKQFSGRMGS MWRILSDVTY PFVSYTTGHE 
      1410       1420       1430       1440       1450
FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY AWRYVRASMT 
      1460       1470       1480       1490       1500
LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP 
      1510       1520       1530       1540       1550
RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT 
      1560       1570       1580       1590       1600
PGCHYIAMPV QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL 
      1610       1620 
VDEAKGSKAV QRGNRLRRMS I

Length:1,621

Mass (Da):178,011

Last modified:June 28, 2011 - v1

Checksum:ⁱ0F00F6E602754505

GO

Sequence cautionⁱ

The sequence AAW42828 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017344 Genomic DNA Translation: AAW42828.1 Sequence problems.
NCBI Reference Sequences More...RefSeqⁱ	XP_570135.1, XM_570135.1

Genome annotation databases

EnsemblFungiⁱ	AAW42828; AAW42828; CND04180
KEGGⁱ	cne:CND04180

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0CP36	Lysophospholipase NTE1		CRYNB		1621	UniRef100_P0CP37

Protein	Similar proteins		Species	Score	Length	Source
P0CP36	Lysophospholipase NTE1		CRYNB		1621	UniRef90_P0CP37
Lysophospholipase NTE1		Cryptococcus neoformans var. grubii c45		1621
Lysophospholipase NTE1		CRYNH		1621
Lysophospholipase NTE1		Cryptococcus neoformans var. grubii Bt85		1619

Protein	Similar proteins		Species	Score	Length	Source
P0CP36	Lysophospholipase NTE1		CRYNB		1621	UniRef50_P0CP37
Lysophospholipase NTE1		CRYNH		1621
Lysophospholipase NTE1		Cryptococcus neoformans var. grubii c45		1621
Lysophospholipase NTE1		Cryptococcus neoformans var. grubii Bt85		1619
Lysophospholipase NTE1		Kwoniella heveanensis CBS 569		1638
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017344 Genomic DNA Translation: AAW42828.1 Sequence problems.
RefSeqⁱ	XP_570135.1, XM_570135.1

3D structure databases

ProteinModelPortalⁱ	P0CP36
SMRⁱ	P0CP36
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	214684.XP_570135.1

STRINGⁱ

214684.XP_570135.1

Proteomic databases

PaxDbⁱ	P0CP36

PaxDbⁱ

P0CP36

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	AAW42828; AAW42828; CND04180
KEGGⁱ	cne:CND04180

Organism-specific databases

EuPathDBⁱ	FungiDB:CND04180

EuPathDBⁱ

FungiDB:CND04180

Phylogenomic databases

eggNOGⁱ	KOG2968 Eukaryota COG0664 LUCA COG1752 LUCA
InParanoidⁱ	P0CP36
KOⁱ	K14676
OrthoDBⁱ	EOG092C0BAH

Family and domain databases

CDDⁱ	cd00038 CAP_ED, 2 hits
Gene3Dⁱ	2.60.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR001423 LysoPLipase_patatin_CS IPR002641 PNPLA_dom IPR014710 RmlC-like_jellyroll
Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 1 hit PF01734 Patatin, 1 hit
SMARTⁱ	View protein in SMART SM00100 cNMP, 2 hits
SUPFAMⁱ	SSF51206 SSF51206, 3 hits SSF52151 SSF52151, 1 hit
PROSITEⁱ	View protein in PROSITE PS50042 CNMP_BINDING_3, 2 hits PS51635 PNPLA, 1 hit PS01237 UPF0028, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTE1_CRYNJ
Accessionⁱ	P0CP36Primary (citable) accession number: P0CP36 Secondary accession number(s): Q55U92, Q5KI53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
	Last sequence update:	June 28, 2011
	Last modified:	November 7, 2018
	This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

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Supporting data

UniProtKB - P0CP36 (NTE1_CRYNJ)

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Lysophospholipase NTE1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ