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Protein

Chromatin modification-related protein EAF1

Gene

EAF1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF1
Alternative name(s):
ESA1-associated factor 1
Vacuolar import and degradation protein 21
Gene namesi
Name:EAF1
Synonyms:VID21
Ordered Locus Names:CNC01040
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:CNC01040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658161 – 985Chromatin modification-related protein EAF1Add BLAST985

Proteomic databases

PaxDbiP0CO98

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi214684.XP_569964.1

Structurei

3D structure databases

ProteinModelPortaliP0CO98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 100HSAPROSITE-ProRule annotationAdd BLAST77
Domaini412 – 471Myb-likeAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili591 – 664Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi478 – 555Pro-richAdd BLAST78

Sequence similaritiesi

Belongs to the EAF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAN Eukaryota
ENOG41100CH LUCA
InParanoidiP0CO98
KOiK11397
OMAiHESHATA
OrthoDBiEOG092C3K1Y

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR014012 HSA_dom
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF07529 HSA, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00573 HSA, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51204 HSA, 1 hit

Sequencei

Sequence statusi: Complete.

P0CO98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHVRAMERI EAKKAENRWS LRQPKKARGP GVPKSHWDYM LEEMEWMRTD
60 70 80 90 100
FAEERRWKVV EAREFAYQVV EWHLASPEEK KALMVGGRGW GECRNVPIPG
110 120 130 140 150
HAGKRKEVTV EVEAEDEDVE MLVGQEGELD GEGEANKVLE SIDEMRVNEK
160 170 180 190 200
ERENRPEDPR ETVNINQDIG EEVDAEGEAD ADGEPENGEA DAEGEADADG
210 220 230 240 250
GPVGDDVVGL SEIDAAQDDT RETSERPSYR RDTVLPNGLV IHKRFANAYE
260 270 280 290 300
IAIARGPVLD TPLANATVDL DTLTKSSSAA TPATVPAEPS VSPDEPASFD
310 320 330 340 350
QLFPDLAMYS GPAPPENDKK YRRDEGGTYS HRMAHTSRIM DIRPILVSTL
360 370 380 390 400
QPAKNLIDGE WDLHDGPYYE EVKGAADIPP NVVAAFNTPF GGKASRPLEH
410 420 430 440 450
MRVPEVPKPA AHHLRAQLLW SPEEDKCLLK LVAMYPFNWD LIADSFNTEM
460 470 480 490 500
ILIPVEKRNP YECWERWYYT FGEGKNKPRQ DAPPSAPPPA PASATQPGTA
510 520 530 540 550
TATPVPQSAV TTPGVPPSAN LPSASGRPQQ TGGNSVSSLP TPTGEALPDG
560 570 580 590 600
APPPPGMSKR DRMAAKPKYE GTKRSVRHQA IYDAVKRMNR RREAARAKSH
610 620 630 640 650
KDNAQRKVIN VHESHSMSFP HVAASTPWEL VEAKYQRDVQ IAQQRQQRAM
660 670 680 690 700
QEQQRQLAIR QQQAMMSAQQ QAQMRPPNMP NVPNMPNAQP IRMGPNGQPM
710 720 730 740 750
PTMAPSQQQL LNAVAAATAA NRQNANGAVQ GNPNVRPMPV VQGQSPQVQQ
760 770 780 790 800
QMLLQAQQMA AQQARVLQAQ AQAQAQQGRA PSMGGNLQPP QLGVSSPFAQ
810 820 830 840 850
SRTPDLPAEG AGPSGINPTP SPAMQAAAIG AQSSPQIATM GRAPSNNVPP
860 870 880 890 900
HLRVPNAGTS SPQISSPMAL PQGIPNGAGM PVQGAQTQGI QIPAAMMNNA
910 920 930 940 950
TVQQLLATLA ASGQQMTPEQ LRGLMLRSAH MQAQAQSQVG NPGTPQMGVQ
960 970 980
NIQGVQHFAR SPSLQNAQSQ PRSSPKPGPA NGQGT
Length:985
Mass (Da):106,869
Last modified:June 28, 2011 - v1
Checksum:iDED28589A7573AB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017343 Genomic DNA Translation: AAW42657.1
RefSeqiXP_569964.1, XM_569964.1

Genome annotation databases

EnsemblFungiiAAW42657; AAW42657; CNC01040
KEGGicne:CNC01040

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017343 Genomic DNA Translation: AAW42657.1
RefSeqiXP_569964.1, XM_569964.1

3D structure databases

ProteinModelPortaliP0CO98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_569964.1

Proteomic databases

PaxDbiP0CO98

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW42657; AAW42657; CNC01040
KEGGicne:CNC01040

Organism-specific databases

EuPathDBiFungiDB:CNC01040

Phylogenomic databases

eggNOGiENOG410IEAN Eukaryota
ENOG41100CH LUCA
InParanoidiP0CO98
KOiK11397
OMAiHESHATA
OrthoDBiEOG092C3K1Y

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR014012 HSA_dom
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF07529 HSA, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00573 HSA, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51204 HSA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAF1_CRYNJ
AccessioniPrimary (citable) accession number: P0CO98
Secondary accession number(s): Q55V60, Q5KL22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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