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Protein

Pre-mRNA-splicing factor CEF1

Gene

CEF1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in pre-mRNA splicing and cell cycle control.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 53H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi81 – 103H-T-H motifPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CEF1
Gene namesi
Name:CEF1
Ordered Locus Names:CNK01590
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiFungiDB:CNK01590

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970981 – 838Pre-mRNA-splicing factor CEF1Add BLAST838

Proteomic databases

PaxDbiP0CO94

Interactioni

Subunit structurei

Associated with the spliceosome.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi214684.XP_567833.1

Structurei

3D structure databases

ProteinModelPortaliP0CO94
SMRiP0CO94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 57HTH myb-type 1PROSITE-ProRule annotationAdd BLAST56
Domaini58 – 107HTH myb-type 2PROSITE-ProRule annotationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili250 – 311Sequence analysisAdd BLAST62
Coiled coili727 – 813Sequence analysisAdd BLAST87

Sequence similaritiesi

Belongs to the CEF1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0050 Eukaryota
COG5147 LUCA
InParanoidiP0CO94
KOiK12860
OMAiYKNYQKQ
OrthoDBiEOG092C1DPM

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR021786 Cdc5p/Cef1
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF11831 Myb_Cef, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 2 hits

Sequencei

Sequence statusi: Complete.

P0CO94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVIVKGGVW RNTEDEILKA AISKYGKNQW ARISSLLVRK TPKQCKARWY
60 70 80 90 100
EWLDPSIKKV EWSKTEDEKL LHLAKLMPTQ WRTIAPIVGR TATQCLERYQ
110 120 130 140 150
KLLDDAEARD NEELGLGAGE DESSKPATDA RGLRPGEIDT DPETRPARPD
160 170 180 190 200
PIDMDDDEKE MLSEARARLA NTQGKKAKRK ARERQLEEAR RLAFLQKKRE
210 220 230 240 250
LKAAGINLRA KPKKKGMDYN ADIPFEKQPA PGFYDVTEEQ AKVHAAPVGS
260 270 280 290 300
TLRALEGKRK QELDEIEERK KRQKKGDGKS NQTQQFVAAR EAQIKKLKEQ
310 320 330 340 350
EQIIRRRKLN LPIPQVGERE LEDIVKIGQA GELARELVGD GNKATEGLLG
360 370 380 390 400
EYEALGQAKM ARTPRTAPQQ DNVMAEARNL RNMMAAQTPL LGEENTPLHG
410 420 430 440 450
PSVGTGFEGA TPRHDVAATP NPLATSARGG VLTSTRTVPG VGTTPLRTPF
460 470 480 490 500
RDDLNINDDA SVYGETPMND RRRLAESRRA LKAGFAALPK PENNFELAET
510 520 530 540 550
EEDEEEAEEA EPLTEEDAAE RDARLKAARE EEERRELERR STVIKKGLPR
560 570 580 590 600
PVNVNTYKLL DDLNSAIVEQ TDEEMAAAFK LVNLEVAMLM KHDSIAHPLP
610 620 630 640 650
GTSTPGGLAS EYDMPEDDFV AEAKNAIHTE LANALGLPGA SDEHLRLAIG
660 670 680 690 700
AAAEENEAAF AEAWAEEREG LVYSPSTRTW VDKTSLSPEE LSACYAAMIN
710 720 730 740 750
ASRDRVIAEA TKAAKAEKKL GKQLGGYQTL NEKAKKAIVD VMEEIHQTKR
760 770 780 790 800
DMETFLMLKG IEEAAAPARL EKIREEVAVL KKRERDLQAR YAELNDRRRE
810 820 830
NLAAIEQLEE DKIVLAAQVA LEAQEGEVAD GDVDMNGA
Length:838
Mass (Da):93,254
Last modified:June 28, 2011 - v1
Checksum:i682DC9EB0E1E61E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017351 Genomic DNA Translation: AAW46316.1
RefSeqiXP_567833.1, XM_567833.1
UniGeneiFne.7726

Genome annotation databases

EnsemblFungiiAAW46316; AAW46316; CNK01590
GeneIDi3254565
KEGGicne:CNK01590

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017351 Genomic DNA Translation: AAW46316.1
RefSeqiXP_567833.1, XM_567833.1
UniGeneiFne.7726

3D structure databases

ProteinModelPortaliP0CO94
SMRiP0CO94
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_567833.1

Proteomic databases

PaxDbiP0CO94

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW46316; AAW46316; CNK01590
GeneIDi3254565
KEGGicne:CNK01590

Organism-specific databases

EuPathDBiFungiDB:CNK01590

Phylogenomic databases

eggNOGiKOG0050 Eukaryota
COG5147 LUCA
InParanoidiP0CO94
KOiK12860
OMAiYKNYQKQ
OrthoDBiEOG092C1DPM

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR021786 Cdc5p/Cef1
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF11831 Myb_Cef, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEF1_CRYNJ
AccessioniPrimary (citable) accession number: P0CO94
Secondary accession number(s): Q55JY9, Q5K9L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 10, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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