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UniProtKB - P0CO48 (KMO_CRYNJ)
Protein
Kynurenine 3-monooxygenase
Gene
BNA4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Functioni
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
UniRule annotationCatalytic activityi
- EC:1.14.13.9UniRule annotation
Cofactori
FADUniRule annotation
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- FAD binding Source: EnsemblFungi
- flavin adenine dinucleotide binding Source: GO_Central
- kynurenine 3-monooxygenase activity Source: GO_Central
- NAD(P)H oxidase H2O2-forming activity Source: GO_Central
GO - Biological processi
- 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-UniRule
- anthranilate metabolic process Source: UniProtKB-UniRule
- kynurenine metabolic process Source: GO_Central
- NAD metabolic process Source: GO_Central
- quinolinate biosynthetic process Source: UniProtKB-UniRule
- tryptophan catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00328 |
Names & Taxonomyi
Protein namesi | Recommended name: Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)Alternative name(s): Biosynthesis of nicotinic acid protein 4UniRule annotation Kynurenine 3-hydroxylaseUniRule annotation |
Gene namesi | Name:BNA4UniRule annotation Ordered Locus Names:CNC04120 |
Organismi | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
Taxonomic identifieri | 214684 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Cryptococcaceae › Cryptococcus › Cryptococcus neoformans species complex › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CNC04120 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane UniRule annotation
Mitochondrion
- mitochondrial outer membrane Source: GO_Central
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361926 | 1 – 506 | Kynurenine 3-monooxygenaseAdd BLAST | 506 |
Proteomic databases
PaxDbi | P0CO48 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 174 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 174 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2614, Eukaryota |
HOGENOMi | CLU_023210_0_1_1 |
InParanoidi | P0CO48 |
OMAi | ISLKCKP |
OrthoDBi | 462247at2759 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
HAMAPi | MF_01971, Kynurenine_monooxygenase, 1 hit |
InterProi | View protein in InterPro IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR027545, Kynurenine_monooxygenase |
Pfami | View protein in Pfam PF01494, FAD_binding_3, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CO48-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQSRARKVL IVGAGPVGAL TALSLHRRGW EVEVWETRDD PRGQDAAPSN
60 70 80 90 100
LRSINLAISS RGLEALRSVD PSIAENFLEE AIPMKGRMIH HTDGKQESQL
110 120 130 140 150
YDPIGGQSIN SISRPILNQR LVQSLPEAVK LRFNTKLKHI DFKNRVAYAS
160 170 180 190 200
HKQETSLLPG EESEKDKKQN TEDEDGTAFD LVIGCDGSWS KVRTAMMRAE
210 220 230 240 250
RIDFSQSFIP HAYIELHMPS DPAFPGGYAM DKNHLHIWPR HAFMLIGLPN
260 270 280 290 300
KDGSFTLTLF IPFSSLELLD TRESAAAFFR EHFPSAVDIV GEKVLLDDFE
310 320 330 340 350
KNPRGNLVTI NCTPSAWSSH AILLGDASHS MVPFYGQGLN CGLEDVRVLS
360 370 380 390 400
SILERHHISP TTTLALGETD PELELALKAY SDERQGDLKA ICELALQNYT
410 420 430 440 450
EMRSHVLSPL HHLRRQVDKV FTTLFRSAPQ ATLSLMEPFP TKKVRGWTSL
460 470 480 490 500
YEMVTFRPDV GYSEALRKER WQKDVVGYAG WIGGVVGVGA AGVFAATMAK
KWLERR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017343 Genomic DNA Translation: AAW42348.1 |
RefSeqi | XP_569655.1, XM_569655.1 |
Genome annotation databases
EnsemblFungii | AAW42348; AAW42348; CNC04120 |
GeneIDi | 3256682 |
KEGGi | cne:CNC04120 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017343 Genomic DNA Translation: AAW42348.1 |
RefSeqi | XP_569655.1, XM_569655.1 |
3D structure databases
SMRi | P0CO48 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5207.AAW42348 |
Proteomic databases
PaxDbi | P0CO48 |
Genome annotation databases
EnsemblFungii | AAW42348; AAW42348; CNC04120 |
GeneIDi | 3256682 |
KEGGi | cne:CNC04120 |
Organism-specific databases
VEuPathDBi | FungiDB:CNC04120 |
Phylogenomic databases
eggNOGi | KOG2614, Eukaryota |
HOGENOMi | CLU_023210_0_1_1 |
InParanoidi | P0CO48 |
OMAi | ISLKCKP |
OrthoDBi | 462247at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00328 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
HAMAPi | MF_01971, Kynurenine_monooxygenase, 1 hit |
InterProi | View protein in InterPro IPR002938, FAD-bd IPR036188, FAD/NAD-bd_sf IPR027545, Kynurenine_monooxygenase |
Pfami | View protein in Pfam PF01494, FAD_binding_3, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KMO_CRYNJ | |
Accessioni | P0CO48Primary (citable) accession number: P0CO48 Secondary accession number(s): Q55W30, Q5KK63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 23, 2022 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families