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Protein

Helicase SWR1

Gene

SWR1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi418 – 425ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
Gene namesi
Name:SWR1
Ordered Locus Names:CNL04590
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiFungiDB:CNL04590

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743661 – 1246Helicase SWR1Add BLAST1246

Proteomic databases

PaxDbiP0CO18

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Protein-protein interaction databases

STRINGi214684.XP_568005.1

Structurei

3D structure databases

ProteinModelPortaliP0CO18
SMRiP0CO18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini405 – 570Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini939 – 1092Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi521 – 524DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 364Glu-richAdd BLAST44

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0388 Eukaryota
ENOG410XP0A LUCA
InParanoidiP0CO18
KOiK11681
OMAiVGWHTEN
OrthoDBiEOG092C1YH4

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

P0CO18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEHNQDLRF LISDDVLNED PMSTGRFAEE DRGSSDTEQL TDNKNDGEEP
60 70 80 90 100
KETAVQAAFD GSDDVNRLEE PHNPVSSTAN IGNFALLESS SAEVSDASCP
110 120 130 140 150
ATMPILVRQS PKTCSQPRTR KVKLSTLSLS SDPDPDINDP EFKARLEDSN
160 170 180 190 200
QDDQDEELDL EMEEADSAGR ESGEGNRDSE DEGLLADADL PIEVLLRRYG
210 220 230 240 250
YPVPEGEGAV NGEPEQSESK GREQAAPTST VSETLPSTKL SLAQPANQTD
260 270 280 290 300
QSLTDTALPE PRVPEQLIIS GKRQRRKKEI WTPDDSEPQH LVGKKRIKKV
310 320 330 340 350
EIVEKVEADV HQNGDGLVIV EEETMGDEDN DDSKVGQEEE DGHEYDSEEE
360 370 380 390 400
YDEDEDEEEE GAKEDNVDWD DRQDKEGDIG PRVRQPFLLR GTLRPYQQAG
410 420 430 440 450
LEWLASLWSN NMNGILADEM GLGKTIQTIA LLGHLACDKG VWGQHLIIVP
460 470 480 490 500
TSVILNWEME FKKFLPGMKV LTYYGNQKER KEKRVGWHTE NTWQVCITSY
510 520 530 540 550
QIVLADQHIF RRKNWCYMIL DEAHNIKNFR SQRWQTLLGF KAQRRLLLTG
560 570 580 590 600
TPLQNNLMEL WSLLYFLMPG GIGADATAVV GFANHKEFME WFSNPMDKAI
610 620 630 640 650
ETGDAMDEET LETVAKLHTL LRPFILRRLK SEVETQLPGK FEHVVYCRLS
660 670 680 690 700
KRQRFLYDEF MSRASTHEAL TTGGYLGVMN TLMQLRKVCN HPDLFEMRPV
710 720 730 740 750
KTSFAMDNVA RDFEPSDILI RKRLLAEEDE RRIDALAIGF GVAHNEAMSG
760 770 780 790 800
WVARARQTYD ASDKLPYAAS PLRRGKLSAP PPKDTRSVEL WLKYRVWAEE
810 820 830 840 850
EFSKRRWESI RATNRQRCGI SPIYGSTFLS LLGNLPNFLL PQDVQSRREE
860 870 880 890 900
TFADFTPPAA KFITSLPERA KSLEDVIDRF AVIPPNAVAR NLATYALPGL
910 920 930 940 950
EPISHPALTD PAFDTLHRSS VKLQIAFPDA SLLQYDCGKL QKLFEMLRDL
960 970 980 990 1000
KSEGHRVLIF TQMTRVLDIL EMFLSHNGHR YLRLDGSTKI EDRQVLTERF
1010 1020 1030 1040 1050
NSDSRIFVFI ASSRSGGVGI NLTGADTVFF YDSDWNPSMD RQCMDRAHRI
1060 1070 1080 1090 1100
GQTREVHIYR FVSSHTVEEN MLRKAEQKRL LDKMVIQEGG FNNDWWGRVG
1110 1120 1130 1140 1150
WKDMFGDVPG ITDVSGVVEK SGEGIIDIQV EGTPVAEDVE VTRPRAGEER
1160 1170 1180 1190 1200
ELARALAEVE DEEDAQAARM AQGEGELDLQ EFEEGPKAVA KRVRVFEPEN
1210 1220 1230 1240
SGTPVTTEAG ETGDVVEEYD DEPGSVEEYM LKWVEEDWDY FSPYRA
Length:1,246
Mass (Da):141,185
Last modified:June 28, 2011 - v1
Checksum:iA28FCC0BFDD2CD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017352 Genomic DNA Translation: AAW46488.1
RefSeqiXP_568005.1, XM_568005.1

Genome annotation databases

EnsemblFungiiAAW46488; AAW46488; CNL04590
KEGGicne:CNL04590

Similar proteinsi

Entry informationi

Entry nameiSWR1_CRYNJ
AccessioniPrimary (citable) accession number: P0CO18
Secondary accession number(s): Q55LY7, Q5K8T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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