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Protein

G antigen 12I

Gene

GAGE12I

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12I
Short name:
GAGE-12I
Gene namesi
Name:GAGE12I
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000215269.5
HostDB:ENSG00000236362.7
HGNCiHGNC:4105 GAGE12I
neXtProtiNX_P0CL82

Pathology & Biotechi

Organism-specific databases

DisGeNETi100008586
2579
26748
645073

Polymorphism and mutation databases

DMDMi332313381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004074931 – 117G antigen 12IAdd BLAST117

Proteomic databases

MaxQBiP0CL82
PRIDEiP0CL82
ProteomicsDBi52507

PTM databases

iPTMnetiP0CL82
PhosphoSitePlusiP0CL82

Expressioni

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
ExpressionAtlasiP0CL82 baseline
GenevisibleiP0CL82 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Subunit structurei

Forms tetramers.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi117808, 2 interactors
IntActiP0CL82, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP0CL82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
InParanoidiP0CL82
OrthoDBiEOG091G0UGV
PhylomeDBiP0CL82
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CL82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,978
Last modified:May 3, 2011 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649339 Genomic DNA No translation available.
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.695912

Genome annotation databases

GeneIDi100008586
2579
26748
645073
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073
UCSCiuc004dof.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649339 Genomic DNA No translation available.
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.695912

3D structure databases

ProteinModelPortaliP0CL82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117808, 2 interactors
IntActiP0CL82, 2 interactors

PTM databases

iPTMnetiP0CL82
PhosphoSitePlusiP0CL82

Polymorphism and mutation databases

DMDMi332313381

Proteomic databases

MaxQBiP0CL82
PRIDEiP0CL82
ProteomicsDBi52507

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008586
2579
26748
645073
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073
UCSCiuc004dof.5 human

Organism-specific databases

CTDi100008586
2579
26748
645073
DisGeNETi100008586
2579
26748
645073
EuPathDBiHostDB:ENSG00000215269.5
HostDB:ENSG00000236362.7
GeneCardsiGAGE12I
HGNCiHGNC:4105 GAGE12I
HPAiHPA043232
neXtProtiNX_P0CL82
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
InParanoidiP0CL82
OrthoDBiEOG091G0UGV
PhylomeDBiP0CL82
TreeFamiTF340669

Miscellaneous databases

PROiPR:P0CL82

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
ExpressionAtlasiP0CL82 baseline
GenevisibleiP0CL82 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGG12I_HUMAN
AccessioniPrimary (citable) accession number: P0CL82
Secondary accession number(s): Q66I50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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