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Protein

G antigen 12G

Gene

GAGE12G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12G
Short name:
GAGE-12G
Gene namesi
Name:GAGE12G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000215269.5
HGNCiHGNC:31907 GAGE12G
MIMi300731 gene
neXtProtiNX_P0CL81

Pathology & Biotechi

Organism-specific databases

DisGeNETi100008586
2579
26748
645073

Polymorphism and mutation databases

DMDMi332313380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004074921 – 117G antigen 12GAdd BLAST117

Proteomic databases

PRIDEiP0CL81
ProteomicsDBi52506

PTM databases

iPTMnetiP0CL81
PhosphoSitePlusiP0CL81

Expressioni

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
ExpressionAtlasiP0CL81 baseline
GenevisibleiP0CL81 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Subunit structurei

Forms tetramers.By similarity

Protein-protein interaction databases

BioGridi117808, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP0CL81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
InParanoidiP0CL81
OrthoDBiEOG091G0UGV
PhylomeDBiP0CL81
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CL81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,978
Last modified:May 3, 2011 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
CCDSiCCDS43947.1
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.695912

Genome annotation databases

EnsembliENST00000445148; ENSP00000416249; ENSG00000215269
GeneIDi100008586
2579
26748
645073
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
CCDSiCCDS43947.1
RefSeqiNP_001091875.1, NM_001098405.2
NP_001091879.1, NM_001098409.1
NP_001468.1, NM_001477.1
NP_066946.1, NM_021123.2
UniGeneiHs.460641
Hs.632808
Hs.695912

3D structure databases

ProteinModelPortaliP0CL81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117808, 2 interactors

PTM databases

iPTMnetiP0CL81
PhosphoSitePlusiP0CL81

Polymorphism and mutation databases

DMDMi332313380

Proteomic databases

PRIDEiP0CL81
ProteomicsDBi52506

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445148; ENSP00000416249; ENSG00000215269
GeneIDi100008586
2579
26748
645073
KEGGihsa:100008586
hsa:2579
hsa:26748
hsa:645073

Organism-specific databases

CTDi100008586
2579
26748
645073
DisGeNETi100008586
2579
26748
645073
EuPathDBiHostDB:ENSG00000215269.5
GeneCardsiGAGE12G
HGNCiHGNC:31907 GAGE12G
HPAiHPA043232
MIMi300731 gene
neXtProtiNX_P0CL81
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
InParanoidiP0CL81
OrthoDBiEOG091G0UGV
PhylomeDBiP0CL81
TreeFamiTF340669

Miscellaneous databases

PROiPR:P0CL81
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215269 Expressed in 56 organ(s), highest expression level in right testis
ExpressionAtlasiP0CL81 baseline
GenevisibleiP0CL81 HS

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGG12G_HUMAN
AccessioniPrimary (citable) accession number: P0CL81
Secondary accession number(s): Q66I50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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