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UniProtKB - P0CL77 (DPOL_PYRAB)
Protein
DNA polymerase 1
Gene
polI
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Functioni
Catalytic activityi
- EC:2.7.7.7
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- nucleotide binding Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase |
Biological process | DNA replication |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:polI Synonyms:pol Ordered Locus Names:PYRAB17200 ORF Names:PAB1128 |
Organismi | Pyrococcus abyssi (strain GE5 / Orsay) |
Taxonomic identifieri | 272844 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000407283 | 1 – 771 | DNA polymerase 1Add BLAST | 771 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P0CL77 |
SMRi | P0CL77 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the DNA polymerase type-B family.Curated
Phylogenomic databases
eggNOGi | arCOG00328, Archaea |
HOGENOMi | CLU_000203_6_0_2 |
OMAi | GNQKSPY |
OrthoDBi | 35869at2157 |
PhylomeDBi | P0CL77 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_thumb IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 2 hits |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CL77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE
60 70 80 90 100
VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI
110 120 130 140 150
REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE
160 170 180 190 200
EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE
210 220 230 240 250
KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV
260 270 280 290 300
EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE
310 320 330 340 350
TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG
410 420 430 440 450
IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI
460 470 480 490 500
PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY
510 520 530 540 550
AKARWYCKEC AESVTAWGRQ YIDLVRRELE SRGFKVLYID TDGLYATIPG
560 570 580 590 600
AKHEEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE
610 620 630 640 650
GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL
660 670 680 690 700
SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG
710 720 730 740 750
YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY
760 770
RKEDLKYQKT KQVGLGAWLK F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ248288 Genomic DNA Translation: CAB50625.1 HE613800 Genomic DNA Translation: CCE71192.1 |
PIRi | C75023 |
RefSeqi | WP_010868838.1, NC_000868.1 |
Genome annotation databases
EnsemblBacteriai | CAB50625; CAB50625; PAB1128 |
GeneIDi | 1496021 |
KEGGi | pab:PAB1128 |
PATRICi | fig|272844.11.peg.1837 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ248288 Genomic DNA Translation: CAB50625.1 HE613800 Genomic DNA Translation: CCE71192.1 |
PIRi | C75023 |
RefSeqi | WP_010868838.1, NC_000868.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4FLT | X-ray | 2.90 | A | 1-771 | [»] | |
4FLV | X-ray | 2.70 | A | 1-771 | [»] | |
4FLW | X-ray | 2.15 | A | 1-771 | [»] | |
4FLX | X-ray | 2.90 | A | 1-771 | [»] | |
4FLY | X-ray | 2.30 | A | 1-771 | [»] | |
4FLZ | X-ray | 3.20 | A | 1-771 | [»] | |
4FM0 | X-ray | 3.12 | A | 1-771 | [»] | |
4FM1 | X-ray | 3.00 | A | 1-771 | [»] | |
4FM2 | X-ray | 2.90 | A | 1-771 | [»] | |
AlphaFoldDBi | P0CL77 | |||||
SMRi | P0CL77 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 272844.PAB1128 |
Genome annotation databases
EnsemblBacteriai | CAB50625; CAB50625; PAB1128 |
GeneIDi | 1496021 |
KEGGi | pab:PAB1128 |
PATRICi | fig|272844.11.peg.1837 |
Phylogenomic databases
eggNOGi | arCOG00328, Archaea |
HOGENOMi | CLU_000203_6_0_2 |
OMAi | GNQKSPY |
OrthoDBi | 35869at2157 |
PhylomeDBi | P0CL77 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit 3.90.1600.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR017964, DNA-dir_DNA_pol_B_CS IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_thumb IPR023211, DNA_pol_palm_dom_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 2 hits |
PRINTSi | PR00106, DNAPOLB |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00116, DNA_POLYMERASE_B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPOL_PYRAB | |
Accessioni | P0CL77Primary (citable) accession number: P0CL77 Secondary accession number(s): G8ZK85, P77916, P77932 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | May 25, 2022 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families