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Entry version 52 (22 Apr 2020)
Sequence version 1 (05 Apr 2011)
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Protein

Outer surface protein A

Gene

ospA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Outer surface protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ospA
Ordered Locus Names:BB_A15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid lp54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224326 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001807 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid lp54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Add BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001807417 – 273Outer surface protein AAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi17N-palmitoyl cysteine1 Publication1
Lipidationi17S-diacylglycerol cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0CL66

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CL66

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0CL66

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1014382_0_0_12

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALIACKQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001809 OM_lipoprot_Borrelia
IPR023322 OM_lipoprot_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00820 Lipoprotein_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00968 OUTRSURFACE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51087 SSF51087, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0CL66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKYLLGIGL ILALIACKQN VSSLDEKNSV SVDLPGEMKV LVSKEKNKDG
60 70 80 90 100
KYDLIATVDK LELKGTSDKN NGSGVLEGVK ADKSKVKLTI SDDLGQTTLE
110 120 130 140 150
VFKEDGKTLV SKKVTSKDKS STEEKFNEKG EVSEKIITRA DGTRLEYTGI
160 170 180 190 200
KSDGSGKAKE VLKGYVLEGT LTAEKTTLVV KEGTVTLSKN ISKSGEVSVE
210 220 230 240 250
LNDTDSSAAT KKTAAWNSGT STLTITVNSK KTKDLVFTKE NTITVQQYDS
260 270
NGTKLEGSAV EITKLDEIKN ALK
Length:273
Mass (Da):29,367
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB53FC01D92F6D431
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti35P → S in strain: CA7. 1
Natural varianti39K → N in strain: PBre and 21343WI. 1
Natural varianti59D → H in strain: 42373NY3. 1
Natural varianti90I → V in strain: CA8. 1
Natural varianti114V → A in strain: PBre. 1
Natural varianti127N → S in strain: CA8. 1
Natural varianti132 – 133VS → LP in strain: CA8. 2
Natural varianti144R → K in strain: 21343WI. 1
Natural varianti149G → E in strain: PBre and 42373NY3. 1
Natural varianti164G → S in strain: PBre. 1
Natural varianti196E → A in strain: CA8 and 21343WI. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14407 Genomic DNA Translation: CAA32579.1
X85739 Genomic DNA Translation: CAA59742.1
X80182 Genomic DNA Translation: CAA56467.1
X69606 Genomic DNA Translation: CAA49314.1
AE000790 Genomic DNA Translation: AAC66260.1
L23136 Genomic DNA Translation: AAA22951.1
L23137 Genomic DNA Translation: AAA22953.1
L23138 Genomic DNA Translation: AAA20947.1
L23139 Genomic DNA Translation: AAA20949.1
L23140 Genomic DNA Translation: AAA20951.1
L23141 Genomic DNA Translation: AAA20953.1
L23142 Genomic DNA Translation: AAA20955.1
L23143 Genomic DNA Translation: AAA20957.1
L23144 Genomic DNA Translation: AAA20959.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F49209
G70208
I40265
S71529

NCBI Reference Sequences

More...
RefSeqi
NP_045688.1, NC_001857.2
WP_010890378.1, NC_001857.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC66260; AAC66260; BB_A15

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1194357

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bbu:BB_A15

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224326.49.peg.1532

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14407 Genomic DNA Translation: CAA32579.1
X85739 Genomic DNA Translation: CAA59742.1
X80182 Genomic DNA Translation: CAA56467.1
X69606 Genomic DNA Translation: CAA49314.1
AE000790 Genomic DNA Translation: AAC66260.1
L23136 Genomic DNA Translation: AAA22951.1
L23137 Genomic DNA Translation: AAA22953.1
L23138 Genomic DNA Translation: AAA20947.1
L23139 Genomic DNA Translation: AAA20949.1
L23140 Genomic DNA Translation: AAA20951.1
L23141 Genomic DNA Translation: AAA20953.1
L23142 Genomic DNA Translation: AAA20955.1
L23143 Genomic DNA Translation: AAA20957.1
L23144 Genomic DNA Translation: AAA20959.1
PIRiF49209
G70208
I40265
S71529
RefSeqiNP_045688.1, NC_001857.2
WP_010890378.1, NC_001857.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FJ1X-ray2.68E/F18-273[»]
1OSPX-ray1.95O18-273[»]
2AF5X-ray2.50A27-273[»]
2FKGX-ray2.40A27-273[»]
2FKJX-ray3.10A/B/C27-273[»]
2G8CX-ray1.15O27-273[»]
2HKDX-ray1.60A27-130[»]
A118-273[»]
2I5VX-ray1.10O27-273[»]
2I5ZX-ray1.20O27-273[»]
2OL6X-ray1.60O27-273[»]
2OL7X-ray1.35A/B27-273[»]
2OL8X-ray1.90O27-273[»]
2OY1X-ray1.86O27-273[»]
2OY5X-ray1.80O27-273[»]
2OY7X-ray1.55A27-273[»]
2OY8X-ray2.00A27-273[»]
2OYBX-ray1.30O27-273[»]
2PI3X-ray1.40O27-273[»]
3AUMX-ray1.60O27-273[»]
5B2AX-ray1.60O27-273[»]
6ICSX-ray1.40O27-273[»]
6IDCX-ray2.01A27-273[»]
6IEIX-ray2.40A27-273[»]
6IYSX-ray3.00O27-273[»]
6J47X-ray1.90O27-273[»]
6J48X-ray1.20O27-273[»]
6J49X-ray1.60O27-273[»]
6J5MX-ray1.85O27-273[»]
6J5NX-ray1.73O27-273[»]
6J5OX-ray1.90O27-273[»]
6J5PX-ray1.80O27-273[»]
6J5QX-ray1.80O27-273[»]
6J5RX-ray1.85O27-273[»]
6J6BX-ray1.90O27-273[»]
6J6CX-ray1.60O27-273[»]
6J6DX-ray1.90O27-273[»]
6J6EX-ray1.50O27-273[»]
SMRiP0CL66
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiP0CL66

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P0CL66

Genome annotation databases

EnsemblBacteriaiAAC66260; AAC66260; BB_A15
GeneIDi1194357
KEGGibbu:BB_A15
PATRICifig|224326.49.peg.1532

Phylogenomic databases

HOGENOMiCLU_1014382_0_0_12
OMAiALIACKQ

Miscellaneous databases

EvolutionaryTraceiP0CL66

Family and domain databases

InterProiView protein in InterPro
IPR001809 OM_lipoprot_Borrelia
IPR023322 OM_lipoprot_dom_sf
PfamiView protein in Pfam
PF00820 Lipoprotein_1, 1 hit
PRINTSiPR00968 OUTRSURFACE
SUPFAMiSSF51087 SSF51087, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSPA_BORBU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CL66
Secondary accession number(s): P0C926
, P14013, Q44882, Q44964, Q44967, Q44969, Q44971, Q57123, Q57272
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 22, 2020
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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