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Protein

Outer surface protein A

Gene

ospA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995).1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein A
Gene namesi
Name:ospA
Ordered Locus Names:BB_A15
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Plasmid lp54

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000001807417 – 273Outer surface protein AAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17N-palmitoyl cysteine1 Publication1
Lipidationi17S-diacylglycerol cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP0CL66

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP0CL66
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CL66

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiALIACKQ

Family and domain databases

InterProiView protein in InterPro
IPR001809 OM_lipoprot_Borrelia
IPR023322 OM_lipoprot_dom_sf
PfamiView protein in Pfam
PF00820 Lipoprotein_1, 1 hit
PRINTSiPR00968 OUTRSURFACE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001127 OM_lipoprot_Borrelia, 1 hit
SUPFAMiSSF51087 SSF51087, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CL66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKYLLGIGL ILALIACKQN VSSLDEKNSV SVDLPGEMKV LVSKEKNKDG
60 70 80 90 100
KYDLIATVDK LELKGTSDKN NGSGVLEGVK ADKSKVKLTI SDDLGQTTLE
110 120 130 140 150
VFKEDGKTLV SKKVTSKDKS STEEKFNEKG EVSEKIITRA DGTRLEYTGI
160 170 180 190 200
KSDGSGKAKE VLKGYVLEGT LTAEKTTLVV KEGTVTLSKN ISKSGEVSVE
210 220 230 240 250
LNDTDSSAAT KKTAAWNSGT STLTITVNSK KTKDLVFTKE NTITVQQYDS
260 270
NGTKLEGSAV EITKLDEIKN ALK
Length:273
Mass (Da):29,367
Last modified:April 5, 2011 - v1
Checksum:iB53FC01D92F6D431
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35P → S in strain: CA7. 1
Natural varianti39K → N in strain: PBre and 21343WI. 1
Natural varianti59D → H in strain: 42373NY3. 1
Natural varianti90I → V in strain: CA8. 1
Natural varianti114V → A in strain: PBre. 1
Natural varianti127N → S in strain: CA8. 1
Natural varianti132 – 133VS → LP in strain: CA8. 2
Natural varianti144R → K in strain: 21343WI. 1
Natural varianti149G → E in strain: PBre and 42373NY3. 1
Natural varianti164G → S in strain: PBre. 1
Natural varianti196E → A in strain: CA8 and 21343WI. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14407 Genomic DNA Translation: CAA32579.1
X85739 Genomic DNA Translation: CAA59742.1
X80182 Genomic DNA Translation: CAA56467.1
X69606 Genomic DNA Translation: CAA49314.1
AE000790 Genomic DNA Translation: AAC66260.1
L23136 Genomic DNA Translation: AAA22951.1
L23137 Genomic DNA Translation: AAA22953.1
L23138 Genomic DNA Translation: AAA20947.1
L23139 Genomic DNA Translation: AAA20949.1
L23140 Genomic DNA Translation: AAA20951.1
L23141 Genomic DNA Translation: AAA20953.1
L23142 Genomic DNA Translation: AAA20955.1
L23143 Genomic DNA Translation: AAA20957.1
L23144 Genomic DNA Translation: AAA20959.1
PIRiF49209
G70208
I40265
S71529
RefSeqiNP_045688.1, NC_001857.2
WP_010890378.1, NC_001857.2

Genome annotation databases

EnsemblBacteriaiAAC66260; AAC66260; BB_A15
GeneIDi1194357
KEGGibbu:BB_A15
PATRICifig|224326.49.peg.1532

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14407 Genomic DNA Translation: CAA32579.1
X85739 Genomic DNA Translation: CAA59742.1
X80182 Genomic DNA Translation: CAA56467.1
X69606 Genomic DNA Translation: CAA49314.1
AE000790 Genomic DNA Translation: AAC66260.1
L23136 Genomic DNA Translation: AAA22951.1
L23137 Genomic DNA Translation: AAA22953.1
L23138 Genomic DNA Translation: AAA20947.1
L23139 Genomic DNA Translation: AAA20949.1
L23140 Genomic DNA Translation: AAA20951.1
L23141 Genomic DNA Translation: AAA20953.1
L23142 Genomic DNA Translation: AAA20955.1
L23143 Genomic DNA Translation: AAA20957.1
L23144 Genomic DNA Translation: AAA20959.1
PIRiF49209
G70208
I40265
S71529
RefSeqiNP_045688.1, NC_001857.2
WP_010890378.1, NC_001857.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FJ1X-ray2.68E/F18-273[»]
1OSPX-ray1.95O18-273[»]
2AF5X-ray2.50A27-273[»]
2FKGX-ray2.40A27-273[»]
2FKJX-ray3.10A/B/C27-273[»]
2G8CX-ray1.15O27-273[»]
2HKDX-ray1.60A27-130[»]
A118-273[»]
2I5VX-ray1.10O27-273[»]
2I5ZX-ray1.20O27-273[»]
2OL6X-ray1.60O27-273[»]
2OL7X-ray1.35A/B27-273[»]
2OL8X-ray1.90O27-273[»]
2OY1X-ray1.86O27-273[»]
2OY5X-ray1.80O27-273[»]
2OY7X-ray1.55A27-273[»]
2OY8X-ray2.00A27-273[»]
2OYBX-ray1.30O27-273[»]
2PI3X-ray1.40O27-273[»]
3AUMX-ray1.60O27-273[»]
5B10X-ray1.60O27-273[»]
5B11X-ray1.20O27-273[»]
5B2AX-ray1.60O27-273[»]
SMRiP0CL66
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0CL66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66260; AAC66260; BB_A15
GeneIDi1194357
KEGGibbu:BB_A15
PATRICifig|224326.49.peg.1532

Phylogenomic databases

OMAiALIACKQ

Miscellaneous databases

EvolutionaryTraceiP0CL66

Family and domain databases

InterProiView protein in InterPro
IPR001809 OM_lipoprot_Borrelia
IPR023322 OM_lipoprot_dom_sf
PfamiView protein in Pfam
PF00820 Lipoprotein_1, 1 hit
PRINTSiPR00968 OUTRSURFACE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001127 OM_lipoprot_Borrelia, 1 hit
SUPFAMiSSF51087 SSF51087, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSPA_BORBU
AccessioniPrimary (citable) accession number: P0CL66
Secondary accession number(s): P0C926
, P14013, Q44882, Q44964, Q44967, Q44969, Q44971, Q57123, Q57272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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