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Protein

Coiled-coil domain-containing protein 39

Gene

ccdc39

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • axonemal dynein complex assembly Source: UniProtKB
  • cilium-dependent cell motility Source: UniProtKB
  • cilium movement Source: GO_Central
  • determination of left/right symmetry Source: ZFIN
  • epithelial cilium movement involved in determination of left/right asymmetry Source: UniProtKB
  • inner dynein arm assembly Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 39Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccdc39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-110603-1 ccdc39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects are the cause of a phenotype related to primary ciliary dyskinesia (PCD). Embryos display heart-looping defects at 36 hours post-fertilization and bilateral or lack of spaw expression at the left lateral plate mesoderm in 14 somite embryos, consistent with compromised fluid flow at the Kupffer's vesicle due to impaired ciliary motility.1 Publication

Keywords - Diseasei

Ciliopathy, Primary ciliary dyskinesia

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004058181 – 947Coiled-coil domain-containing protein 39Add BLAST947

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CK98

PRoteomics IDEntifications database

More...
PRIDEi
P0CK98

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000022810

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0CK98

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 194Sequence analysisAdd BLAST179
Coiled coili221 – 402Sequence analysisAdd BLAST182
Coiled coili471 – 522Sequence analysisAdd BLAST52
Coiled coili582 – 813Sequence analysisAdd BLAST232

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC39 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHS4 Eukaryota
ENOG410ZNZ9 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CK98

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CK98

TreeFam database of animal gene trees

More...
TreeFami
TF329312

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033290 CCDC39

The PANTHER Classification System

More...
PANTHERi
PTHR18962 PTHR18962, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CK98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSALLEEVG WDADFAIPVA NAENKALEEQ IRKKQKDILN LDNKLNKHKD
60 70 80 90 100
VINALTEHLK NLKQEVSHNQ ALCKAKEKET ESEVHLKALA ERETGRLKQE
110 120 130 140 150
ITRLESQLTT LNEKKNAQEN SIFKATQKID ELTSQLNWDQ QTLEAFLQES
160 170 180 190 200
AHKDEDTMAI IKYAKQDERK IKELTLNIEK LTLESNQKRK TLDNELTETV
210 220 230 240 250
TSQIALDKTA ESFRQAHTER QELISQWENT IEQMRKRDQD IQQCAMMLAE
260 270 280 290 300
LNQTIREKND LIKERKDFLE REIENNKELE RNIGTVERQA FRLRQQLQEE
310 320 330 340 350
EKNQRRLQDE VEVLKGTVDR TATDVETSRS QLSSMKKDIQ DKTTKVEEAQ
360 370 380 390 400
LHNAALEEKL RMVTEAVLNG EEQAAQMEQL LREQEQNIKE IDSQLLRQKE
410 420 430 440 450
LLFKKSQEVQ ALRDKEKNVT AEICATRTAL SNLDSKLRKL DQNFLQQQMI
460 470 480 490 500
ISNQDFQIQM LERKTLHLQG KVNTEEKKAL EKKVADLAAS LEEKKKTAAN
510 520 530 540 550
LNKQLKKLQD DIRCIKKDTE KIGAEKTNLS TKIQEVELFI ETSEKERKKS
560 570 580 590 600
RLKKQDSMVE KGLLKMEVQR LRNLLYDRAD GVLTLEKRRL QLQTAMKERE
610 620 630 640 650
EEIRVHREML NKQVKLTEQE RQGLSAAVNE AMSKIDKQRK RYEVLSVSLA
660 670 680 690 700
PPEGEEDKSQ AYFIIKAAQE KEELQRKGDE LDAKIRKTEK EIHALENTLQ
710 720 730 740 750
VVNNCNSTHR KALTKVTESS PAHQEKLKLE EQRRAAEEKY KYKRRQTQEL
760 770 780 790 800
QEDIESMSNT LEGLLQEEKV LNEGIERTQA HVLSLNKDIL SQEEKINRAV
810 820 830 840 850
KQCAKYTKEI RSGKQSTEKT FEERDIELRE LRDFNKSINK MLLDAMEGNP
860 870 880 890 900
ELSSILQIHF TQAGLSLPSP SSTPSSRLSS KPSSARSSAS LHRSSNLSAS
910 920 930 940
SSPRSQSVSS PQMKTVDLGL GLSVTSPRGS QPSSAGSSRS SSKCKSP
Length:947
Mass (Da):108,989
Last modified:February 4, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBC9949973C51E69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CABZ01021592 Genomic DNA No translation available.
CABZ01055305 Genomic DNA No translation available.
CABZ01055306 Genomic DNA No translation available.
CABZ01055307 Genomic DNA No translation available.
CABZ01055310 Genomic DNA No translation available.
CABZ01068420 Genomic DNA No translation available.
CABZ01068421 Genomic DNA No translation available.
CABZ01080220 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_017206828.1, XM_017351339.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dr.157050
Dr.158525

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01021592 Genomic DNA No translation available.
CABZ01055305 Genomic DNA No translation available.
CABZ01055306 Genomic DNA No translation available.
CABZ01055307 Genomic DNA No translation available.
CABZ01055310 Genomic DNA No translation available.
CABZ01068420 Genomic DNA No translation available.
CABZ01068421 Genomic DNA No translation available.
CABZ01080220 Genomic DNA No translation available.
RefSeqiXP_017206828.1, XM_017351339.1
UniGeneiDr.157050
Dr.158525

3D structure databases

SMRiP0CK98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000022810

Proteomic databases

PaxDbiP0CK98
PRIDEiP0CK98

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-110603-1 ccdc39

Phylogenomic databases

eggNOGiENOG410IHS4 Eukaryota
ENOG410ZNZ9 LUCA
InParanoidiP0CK98
PhylomeDBiP0CK98
TreeFamiTF329312

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CK98

Family and domain databases

InterProiView protein in InterPro
IPR033290 CCDC39
PANTHERiPTHR18962 PTHR18962, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD39_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CK98
Secondary accession number(s): E7F0V3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: February 4, 2015
Last modified: October 10, 2018
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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