UniProtKB - P0CK97 (S35E2_HUMAN)
Protein
Solute carrier family 35 member E2A
Gene
SLC35E2A
Organism
Homo sapiens (Human)
Status
Functioni
Putative transporter.By similarity
GO - Molecular functioni
- antiporter activity Source: GO_Central
- pyrimidine nucleotide-sugar transmembrane transporter activity Source: GO_Central
- transmembrane transporter activity Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member E2ACurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000215790.6 |
HGNCi | HGNC:20863 SLC35E2A |
neXtProti | NX_P0CK97 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000215790 |
Polymorphism and mutation databases
BioMutai | SLC35E2 |
DMDMi | 325530285 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000405314 | 1 – 266 | Solute carrier family 35 member E2AAdd BLAST | 266 |
Proteomic databases
EPDi | P0CK97 |
MaxQBi | P0CK97 |
PaxDbi | P0CK97 |
PeptideAtlasi | P0CK97 |
PRIDEi | P0CK97 |
ProteomicsDBi | 52502 52503 [P0CK97-2] |
TopDownProteomicsi | P0CK97-2 [P0CK97-2] |
PTM databases
iPTMneti | P0CK97 |
PhosphoSitePlusi | P0CK97 |
SwissPalmi | P0CK97 |
Expressioni
Gene expression databases
Bgeei | ENSG00000215790 Expressed in 144 organ(s), highest expression level in primary visual cortex |
Genevisiblei | P0CK97 HS |
Organism-specific databases
HPAi | HPA062711 |
Interactioni
Protein-protein interaction databases
BioGridi | 115235, 1 interactor |
IntActi | P0CK97, 2 interactors |
STRINGi | 9606.ENSP00000246421 |
Structurei
3D structure databases
ProteinModelPortali | P0CK97 |
SMRi | P0CK97 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1441 Eukaryota ENOG410XP1S LUCA |
GeneTreei | ENSGT00940000159351 |
InParanoidi | P0CK97 |
KOi | K15284 |
OMAi | CPMLPAS |
OrthoDBi | 1104499at2759 |
PhylomeDBi | P0CK97 |
TreeFami | TF331257 |
Family and domain databases
InterProi | View protein in InterPro IPR004853 Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151 TPT, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P0CK97-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGRPSD
210 220 230 240 250
REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP GDFQVPQALH
260
RVALSMALPC PMLPAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | R → W in BC062371 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040665 | 245 – 266 | VPQAL…MLPAS → AQ in isoform 2. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049665 mRNA Translation: CAB41241.1 AL031282 Genomic DNA No translation available. BC062371 mRNA No translation available. BC101666 mRNA Translation: AAI01667.1 BC112289 mRNA Translation: AAI12290.1 |
CCDSi | CCDS33.1 [P0CK97-1] CCDS55560.1 [P0CK97-2] |
RefSeqi | NP_001186716.1, NM_001199787.1 [P0CK97-2] NP_878258.1, NM_182838.2 [P0CK97-1] |
UniGenei | Hs.655255 Hs.707620 Hs.736504 Hs.744864 |
Genome annotation databases
Ensembli | ENST00000355439; ENSP00000347614; ENSG00000215790 [P0CK97-2] ENST00000643905; ENSP00000495949; ENSG00000215790 [P0CK97-1] |
GeneIDi | 9906 |
KEGGi | hsa:9906 |
UCSCi | uc001ahy.4 human [P0CK97-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049665 mRNA Translation: CAB41241.1 AL031282 Genomic DNA No translation available. BC062371 mRNA No translation available. BC101666 mRNA Translation: AAI01667.1 BC112289 mRNA Translation: AAI12290.1 |
CCDSi | CCDS33.1 [P0CK97-1] CCDS55560.1 [P0CK97-2] |
RefSeqi | NP_001186716.1, NM_001199787.1 [P0CK97-2] NP_878258.1, NM_182838.2 [P0CK97-1] |
UniGenei | Hs.655255 Hs.707620 Hs.736504 Hs.744864 |
3D structure databases
ProteinModelPortali | P0CK97 |
SMRi | P0CK97 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 115235, 1 interactor |
IntActi | P0CK97, 2 interactors |
STRINGi | 9606.ENSP00000246421 |
PTM databases
iPTMneti | P0CK97 |
PhosphoSitePlusi | P0CK97 |
SwissPalmi | P0CK97 |
Polymorphism and mutation databases
BioMutai | SLC35E2 |
DMDMi | 325530285 |
Proteomic databases
EPDi | P0CK97 |
MaxQBi | P0CK97 |
PaxDbi | P0CK97 |
PeptideAtlasi | P0CK97 |
PRIDEi | P0CK97 |
ProteomicsDBi | 52502 52503 [P0CK97-2] |
TopDownProteomicsi | P0CK97-2 [P0CK97-2] |
Protocols and materials databases
DNASUi | 9906 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000355439; ENSP00000347614; ENSG00000215790 [P0CK97-2] ENST00000643905; ENSP00000495949; ENSG00000215790 [P0CK97-1] |
GeneIDi | 9906 |
KEGGi | hsa:9906 |
UCSCi | uc001ahy.4 human [P0CK97-1] |
Organism-specific databases
CTDi | 9906 |
EuPathDBi | HostDB:ENSG00000215790.6 |
GeneCardsi | SLC35E2A |
HGNCi | HGNC:20863 SLC35E2A |
HPAi | HPA062711 |
neXtProti | NX_P0CK97 |
OpenTargetsi | ENSG00000215790 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1441 Eukaryota ENOG410XP1S LUCA |
GeneTreei | ENSGT00940000159351 |
InParanoidi | P0CK97 |
KOi | K15284 |
OMAi | CPMLPAS |
OrthoDBi | 1104499at2759 |
PhylomeDBi | P0CK97 |
TreeFami | TF331257 |
Miscellaneous databases
ChiTaRSi | SLC35E2 human |
GenomeRNAii | 9906 |
PROi | PR:P0CK97 |
Gene expression databases
Bgeei | ENSG00000215790 Expressed in 144 organ(s), highest expression level in primary visual cortex |
Genevisiblei | P0CK97 HS |
Family and domain databases
InterProi | View protein in InterPro IPR004853 Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151 TPT, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | S35E2_HUMAN | |
Accessioni | P0CK97Primary (citable) accession number: P0CK97 Secondary accession number(s): B3KWR0 Q9Y3J8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | January 16, 2019 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM