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Entry version 65 (16 Oct 2019)
Sequence version 1 (08 Mar 2011)
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Protein

Solute carrier family 35 member E2A

Gene

SLC35E2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 35 member E2ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC35E2AImported
Synonyms:SLC35E2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20863 SLC35E2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0CK97

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215790

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P0CK97

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC35E2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
325530285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004053141 – 266Solute carrier family 35 member E2AAdd BLAST266

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P0CK97

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P0CK97

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CK97

PeptideAtlas

More...
PeptideAtlasi
P0CK97

PRoteomics IDEntifications database

More...
PRIDEi
P0CK97

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52502 [P0CK97-1]
52503 [P0CK97-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P0CK97-2 [P0CK97-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CK97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0CK97

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P0CK97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215790 Expressed in 144 organ(s), highest expression level in primary visual cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0CK97 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062711

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115235, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P0CK97, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000246421

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CK97

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1441 Eukaryota
ENOG410XP1S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159351

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CK97

KEGG Orthology (KO)

More...
KOi
K15284

Identification of Orthologs from Complete Genome Data

More...
OMAi
STNIMDX

Database of Orthologous Groups

More...
OrthoDBi
1104499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CK97

TreeFam database of animal gene trees

More...
TreeFami
TF331257

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004853 Sugar_P_trans_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03151 TPT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0CK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGRPSD
210 220 230 240 250
REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP GDFQVPQALH
260
RVALSMALPC PMLPAS
Length:266
Mass (Da):29,079
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16C1B2648C0322D5
GO
Isoform 2 (identifier: P0CK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: VPQALHRVALSMALPCPMLPAS → AQ

Show »
Length:246
Mass (Da):26,993
Checksum:i4F887B9811334010
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti204R → W in BC062371 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040665245 – 266VPQAL…MLPAS → AQ in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL049665 mRNA Translation: CAB41241.1
AL031282 Genomic DNA No translation available.
BC062371 mRNA No translation available.
BC101666 mRNA Translation: AAI01667.1
BC112289 mRNA Translation: AAI12290.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33.1 [P0CK97-1]
CCDS55560.1 [P0CK97-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001186716.1, NM_001199787.1 [P0CK97-2]
NP_878258.1, NM_182838.2 [P0CK97-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355439; ENSP00000347614; ENSG00000215790 [P0CK97-2]
ENST00000643905; ENSP00000495949; ENSG00000215790 [P0CK97-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9906

UCSC genome browser

More...
UCSCi
uc001ahy.4 human [P0CK97-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049665 mRNA Translation: CAB41241.1
AL031282 Genomic DNA No translation available.
BC062371 mRNA No translation available.
BC101666 mRNA Translation: AAI01667.1
BC112289 mRNA Translation: AAI12290.1
CCDSiCCDS33.1 [P0CK97-1]
CCDS55560.1 [P0CK97-2]
RefSeqiNP_001186716.1, NM_001199787.1 [P0CK97-2]
NP_878258.1, NM_182838.2 [P0CK97-1]

3D structure databases

SMRiP0CK97
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115235, 1 interactor
IntActiP0CK97, 2 interactors
STRINGi9606.ENSP00000246421

PTM databases

iPTMnetiP0CK97
PhosphoSitePlusiP0CK97
SwissPalmiP0CK97

Polymorphism and mutation databases

BioMutaiSLC35E2
DMDMi325530285

Proteomic databases

MassIVEiP0CK97
MaxQBiP0CK97
PaxDbiP0CK97
PeptideAtlasiP0CK97
PRIDEiP0CK97
ProteomicsDBi52502 [P0CK97-1]
52503 [P0CK97-2]
TopDownProteomicsiP0CK97-2 [P0CK97-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9906

Genome annotation databases

EnsembliENST00000355439; ENSP00000347614; ENSG00000215790 [P0CK97-2]
ENST00000643905; ENSP00000495949; ENSG00000215790 [P0CK97-1]
GeneIDi9906
KEGGihsa:9906
UCSCiuc001ahy.4 human [P0CK97-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9906

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC35E2A
HGNCiHGNC:20863 SLC35E2A
HPAiHPA062711
neXtProtiNX_P0CK97
OpenTargetsiENSG00000215790

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00940000159351
InParanoidiP0CK97
KOiK15284
OMAiSTNIMDX
OrthoDBi1104499at2759
PhylomeDBiP0CK97
TreeFamiTF331257

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC35E2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9906
PharosiP0CK97

Protein Ontology

More...
PROi
PR:P0CK97

Gene expression databases

BgeeiENSG00000215790 Expressed in 144 organ(s), highest expression level in primary visual cortex
GenevisibleiP0CK97 HS

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35E2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CK97
Secondary accession number(s): B3KWR0
, O75035, Q2TAY8, Q569F8, Q5CZA4, Q5QPR8, Q9Y3J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 16, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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