UniProtKB - P0CK96 (S352B_HUMAN)
Protein
Solute carrier family 35 member E2B
Gene
SLC35E2B
Organism
Homo sapiens (Human)
Status
Functioni
Putative transporter.By similarity
GO - Molecular functioni
- antiporter activity Source: GO_Central
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- blastocyst hatching Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P0CK96 |
Protein family/group databases
TCDBi | 2.A.7.9.7, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member E2B |
Gene namesi | Name:SLC35E2B Synonyms:KIAA0447 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33941, SLC35E2B |
neXtProti | NX_P0CK96 |
VEuPathDBi | HostDB:ENSG00000189339.11 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 219 – 241 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 296 – 316 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 347 – 367 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 728661 |
OpenTargetsi | ENSG00000189339 |
Miscellaneous databases
Pharosi | P0CK96, Tdark |
Genetic variation databases
BioMutai | SLC35E2B |
DMDMi | 325530284 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305057 | 1 – 405 | Solute carrier family 35 member E2BAdd BLAST | 405 |
Proteomic databases
EPDi | P0CK96 |
jPOSTi | P0CK96 |
MassIVEi | P0CK96 |
MaxQBi | P0CK96 |
PaxDbi | P0CK96 |
PeptideAtlasi | P0CK96 |
PRIDEi | P0CK96 |
ProteomicsDBi | 52501 |
PTM databases
iPTMneti | P0CK96 |
PhosphoSitePlusi | P0CK96 |
SwissPalmi | P0CK96 |
Expressioni
Gene expression databases
Bgeei | ENSG00000189339, Expressed in brain and 252 other tissues |
ExpressionAtlasi | P0CK96, baseline and differential |
Genevisiblei | P0CK96, HS |
Organism-specific databases
HPAi | ENSG00000189339, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000481694 |
Miscellaneous databases
RNActi | P0CK96, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00940000159351 |
HOGENOMi | CLU_019048_2_0_1 |
InParanoidi | P0CK96 |
OMAi | IYLTLWF |
OrthoDBi | 1104499at2759 |
PhylomeDBi | P0CK96 |
TreeFami | TF331257 |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P0CK96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGLLVN
210 220 230 240 250
LSLIPVMGGL ALCTATEISF NVLGFSAALS TNIMDCLQNV FSKKLLSGDK
260 270 280 290 300
YRFSAPELQF YTSAAAVAML VPARVFFTDV PVIGRSGKSF SYNQDVVLLL
310 320 330 340 350
LTDGVLFHLQ SVTAYALMGK ISPVTFSVAS TVKHALSIWL SVIVFGNKIT
360 370 380 390 400
SLSAVGTALV TVGVLLYNKA RQHQQEALQS LAAATGRAPD DTVEPLLPQD
PRQHP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUK8 | A0A087WUK8_HUMAN | HCG2036609, isoform CRA_a | SLC35E2B hCG_2036609 | 246 | Annotation score: |
Sequence cautioni
The sequence BAA32292 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 312 | V → I in BAA32292 (PubMed:9455484).Curated | 1 | |
Sequence conflicti | 312 | V → I in BAG54222 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 312 | V → I in CAI56761 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 399 | Q → R in BAG54222 (PubMed:17974005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007916 mRNA Translation: BAA32292.3 Different initiation. AK125619 mRNA Translation: BAG54222.1 CR936618 mRNA Translation: CAI56761.1 AL031282 Genomic DNA No translation available. AL691432 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56159.1 BC110653 mRNA Translation: AAI10654.1 |
CCDSi | CCDS44041.1 |
RefSeqi | NP_001104251.1, NM_001110781.2 NP_001277193.1, NM_001290264.1 |
Genome annotation databases
Ensembli | ENST00000611123; ENSP00000484635; ENSG00000189339 ENST00000617444; ENSP00000481694; ENSG00000189339 |
GeneIDi | 728661 |
KEGGi | hsa:728661 |
UCSCi | uc031tmq.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007916 mRNA Translation: BAA32292.3 Different initiation. AK125619 mRNA Translation: BAG54222.1 CR936618 mRNA Translation: CAI56761.1 AL031282 Genomic DNA No translation available. AL691432 Genomic DNA No translation available. CH471183 Genomic DNA Translation: EAW56159.1 BC110653 mRNA Translation: AAI10654.1 |
CCDSi | CCDS44041.1 |
RefSeqi | NP_001104251.1, NM_001110781.2 NP_001277193.1, NM_001290264.1 |
3D structure databases
SMRi | P0CK96 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000481694 |
Protein family/group databases
TCDBi | 2.A.7.9.7, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | P0CK96 |
PhosphoSitePlusi | P0CK96 |
SwissPalmi | P0CK96 |
Genetic variation databases
BioMutai | SLC35E2B |
DMDMi | 325530284 |
Proteomic databases
EPDi | P0CK96 |
jPOSTi | P0CK96 |
MassIVEi | P0CK96 |
MaxQBi | P0CK96 |
PaxDbi | P0CK96 |
PeptideAtlasi | P0CK96 |
PRIDEi | P0CK96 |
ProteomicsDBi | 52501 |
Protocols and materials databases
Antibodypediai | 62304, 51 antibodies |
Genome annotation databases
Ensembli | ENST00000611123; ENSP00000484635; ENSG00000189339 ENST00000617444; ENSP00000481694; ENSG00000189339 |
GeneIDi | 728661 |
KEGGi | hsa:728661 |
UCSCi | uc031tmq.2, human |
Organism-specific databases
CTDi | 728661 |
DisGeNETi | 728661 |
GeneCardsi | SLC35E2B |
HGNCi | HGNC:33941, SLC35E2B |
HPAi | ENSG00000189339, Low tissue specificity |
neXtProti | NX_P0CK96 |
OpenTargetsi | ENSG00000189339 |
VEuPathDBi | HostDB:ENSG00000189339.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1441, Eukaryota |
GeneTreei | ENSGT00940000159351 |
HOGENOMi | CLU_019048_2_0_1 |
InParanoidi | P0CK96 |
OMAi | IYLTLWF |
OrthoDBi | 1104499at2759 |
PhylomeDBi | P0CK96 |
TreeFami | TF331257 |
Enzyme and pathway databases
PathwayCommonsi | P0CK96 |
Miscellaneous databases
BioGRID-ORCSi | 728661, 6 hits in 874 CRISPR screens |
ChiTaRSi | SLC35E2B, human |
GenomeRNAii | 728661 |
Pharosi | P0CK96, Tdark |
PROi | PR:P0CK96 |
RNActi | P0CK96, protein |
Gene expression databases
Bgeei | ENSG00000189339, Expressed in brain and 252 other tissues |
ExpressionAtlasi | P0CK96, baseline and differential |
Genevisiblei | P0CK96, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S352B_HUMAN | |
Accessioni | P0CK96Primary (citable) accession number: P0CK96 Secondary accession number(s): B3KWR0 Q9Y3J8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM