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Entry version 58 (10 Feb 2021)
Sequence version 1 (08 Mar 2011)
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Protein

Putative lipoprotein AcfD homolog

Gene

yghJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.Curated

Miscellaneous

In many other E.coli strains this gene is part of a type II secretion system, but in MG1655 the locus is missing a number of genes.Curated

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G7541-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M98.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative lipoprotein AcfD homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yghJ
Ordered Locus Names:b4466, JW5925
ORF Names:ECK2968
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002061924 – 1520Putative lipoprotein AcfD homologAdd BLAST1497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CK95

PRoteomics IDEntifications database

More...
PRIDEi
P0CK95

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262979, 9 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1081 – 1381Peptidase M60PROSITE-ProRule annotationAdd BLAST301

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To V.cholerae AcfD (VC_0845).Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3064, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006312_0_0_6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025385, DUF4092
IPR035423, M60-like_N
IPR042279, Pep_M60_3
IPR031161, Peptidase_M60_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13322, DUF4092, 1 hit
PF17291, M60-like_N, 1 hit
PF13402, Peptidase_M60, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01276, M60-like, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51723, PEPTIDASE_M60, 1 hit
PS51257, PROKAR_LIPOPROTEIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0CK95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKFKYKKS LLAAILSATL LAGCDGGGSG SSSDTPPVDS GTGSLPEVKP
60 70 80 90 100
DPTPNPEPTP EPTPDPEPTP EPIPDPEPTP EPEPEPVPTK TGYLTLGGSQ
110 120 130 140 150
RVTGATCNGE SSDGFTFKPG EDVTCVAGNT TIATFNTQSE AARSLRAVEK
160 170 180 190 200
VSFSLEDAQE LAGSDDKKSN AVSLVTSSNS CPANTEQVCL TFSSVIESKR
210 220 230 240 250
FDSLYKQIDL APEEFKKLVN EEVENNAATD KAPSTHTSPV VPVTTPGTKP
260 270 280 290 300
DLNASFVSAN AEQFYQYQPT EIILSEGRLV DSQGYGVAGV NYYTNSGRGV
310 320 330 340 350
TGENGEFSFS WGETISFGID TFELGSVRGN KSTIALTELG DEVRGANIDQ
360 370 380 390 400
LIHRYSTTGQ NNTRVVPDDV RKVFAEYPNV INEIINLSLS NGATLGEGEQ
410 420 430 440 450
VVNLPNEFIE QFNTGQAKEI DTAICAKTDG CNEARWFSLT TRNVNDGQIQ
460 470 480 490 500
GVINKLWGVD TNYKSVSKFH VFHDSTNFYG STGNARGQAV VNISNAAFPI
510 520 530 540 550
LMARNDKNYW LAFGEKRAWD KNELAYITEA PSLVEPENVT RDTATFNLPF
560 570 580 590 600
ISLGQVGEGK LMVIGNPHYN SILRCPNGYS WNGGVNKDGQ CTLNSDPDDM
610 620 630 640 650
KNFMENVLRY LSDDKWKPDA KASMTVGTNL DTVYFKRHGQ VTGNSAAFDF
660 670 680 690 700
HPDFAGISVE HLSSYGDLDP QEMPLLILNG FEYVTQVGND PYAIPLRADT
710 720 730 740 750
SKPKLTQQDV TDLIAYLNKG GSVLIMENVM SNLKEESASG FVRLLDAAGL
760 770 780 790 800
SMALNKSVVN NDPQGYPNRV RQQRATGIWV YERYPAVDGA LPYTIDSKTG
810 820 830 840 850
EVKWKYQVEN KPDDKPKLEV ASWLEDVDGK QETRYAFIDE ADHKTEDSLK
860 870 880 890 900
AAKEKIFAAF PGLKECTNPA YHYEVNCLEY RPGTGVPVTG GMYVPQYTQL
910 920 930 940 950
SLNADTAKAM VQAADLGTNI QRLYQHELYF RTNGRKGERL SSVDLERLYQ
960 970 980 990 1000
NMSVWLWNDT SYRYEEGKND ELGFKTFTEF LNCYANDAYA GGTKCSADLK
1010 1020 1030 1040 1050
KSLVDNNMIY GDGSSKAGMM NPSYPLNYME KPLTRLMLGR SWWDLNIKVD
1060 1070 1080 1090 1100
VEKYPGAVSE EGQNVTETIS LYSNPTKWFA GNMQSTGLWA PAQKEVTIKS
1110 1120 1130 1140 1150
NANVPVTVTV ALADDLTGRE KHEVALNRPP RVTKTYSLDA SGTVKFKVPY
1160 1170 1180 1190 1200
GGLIYIKGNS STNESASFTF TGVVKAPFYK DGAWKNDLNS PAPLGELESD
1210 1220 1230 1240 1250
AFVYTTPKKN LNASNYTGGL EQFANDLDTF ASSMNDFYGR DSEDGKHRMF
1260 1270 1280 1290 1300
TYKNLPGHKH RFTNDVQISI GDAHSGYPVM NSSFSPNSTT LPTTPLNDWL
1310 1320 1330 1340 1350
IWHEVGHNAA ETPLTVPGAT EVANNVLALY MQDRYLGKMN RVADDITVAP
1360 1370 1380 1390 1400
EYLEESNNQA WARGGAGDRL LMYAQLKEWA EKNFDIKKWY PDGTPLPEFY
1410 1420 1430 1440 1450
SEREGMKGWN LFQLMHRKAR GDEVSNDKFG GKNYCAESNG NAADTLMLCA
1460 1470 1480 1490 1500
SWVAQTDLSE FFKKWNPGAN AYQLPGASEM SFEGGVSQSA YNTLASLDLP
1510 1520
KPEQGPETIN QVTEHKMSAE
Length:1,520
Mass (Da):167,246
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC835E4953471A7B3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA69140 differs from that shown. Reason: Frameshift.Curated
The sequence AAA69141 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1358N → G in strain: O15:H- / 83/39 /ETEC. 1
Natural varianti1392 – 1402DGTPLPEFYSE → EGELPKFFSD in strain: O15:H- / 83/39 / ETEC. Add BLAST11
Natural varianti1423 – 1428EVSNDK → DVGDKT in strain: O15:H- / 83/39 / ETEC. 6
Natural varianti1498D → K in strain: O15:H- / 83/39 /ETEC. 1
Natural varianti1511Q → K in strain: O15:H- / 83/39 /ETEC. 1
Natural varianti1519A → V in strain: O15:H- / 83/39 /ETEC. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69141.1 Frameshift.
U28377 Genomic DNA Translation: AAA69140.1 Frameshift.
U00096 Genomic DNA Translation: AAT48156.1
AP009048 Genomic DNA Translation: BAE77034.1
AF426313 Genomic DNA Translation: AAL60194.1

NCBI Reference Sequences

More...
RefSeqi
WP_001034469.1, NZ_LN832404.1
YP_026189.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT48156; AAT48156; b4466
BAE77034; BAE77034; BAE77034

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2847716
57729208

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5925
eco:b4466

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3758

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69141.1 Frameshift.
U28377 Genomic DNA Translation: AAA69140.1 Frameshift.
U00096 Genomic DNA Translation: AAT48156.1
AP009048 Genomic DNA Translation: BAE77034.1
AF426313 Genomic DNA Translation: AAL60194.1
RefSeqiWP_001034469.1, NZ_LN832404.1
YP_026189.1, NC_000913.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262979, 9 interactors
STRINGi511145.b4466

Protein family/group databases

MEROPSiM98.001

Proteomic databases

PaxDbiP0CK95
PRIDEiP0CK95

Genome annotation databases

EnsemblBacteriaiAAT48156; AAT48156; b4466
BAE77034; BAE77034; BAE77034
GeneIDi2847716
57729208
KEGGiecj:JW5925
eco:b4466
PATRICifig|1411691.4.peg.3758

Phylogenomic databases

eggNOGiCOG3064, Bacteria
HOGENOMiCLU_006312_0_0_6

Enzyme and pathway databases

BioCyciEcoCyc:G7541-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CK95

Family and domain databases

Gene3Di1.10.390.30, 1 hit
InterProiView protein in InterPro
IPR025385, DUF4092
IPR035423, M60-like_N
IPR042279, Pep_M60_3
IPR031161, Peptidase_M60_dom
PfamiView protein in Pfam
PF13322, DUF4092, 1 hit
PF17291, M60-like_N, 1 hit
PF13402, Peptidase_M60, 1 hit
SMARTiView protein in SMART
SM01276, M60-like, 1 hit
PROSITEiView protein in PROSITE
PS51723, PEPTIDASE_M60, 1 hit
PS51257, PROKAR_LIPOPROTEIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACFD_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CK95
Secondary accession number(s): Q2M9M2
, Q46837, Q46838, Q6BF58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 10, 2021
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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