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Protein

Humanin-like 8

Gene

MTRNR2L8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

GO - Molecular functioni

  • receptor antagonist activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 8Curated
Short name:
HN81 Publication
Alternative name(s):
MT-RNR2-like protein 8Imported
Gene namesi
Name:MTRNR2L8Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255823.2
HGNCiHGNC:37165 MTRNR2L8
neXtProtiNX_P0CJ75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255823
ENSG00000269028

Polymorphism and mutation databases

BioMutaiMTRNR2L8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045571 – 24Humanin-like 8Add BLAST24

Proteomic databases

PaxDbiP0CJ75
PRIDEiP0CJ75
ProteomicsDBi52489

Expressioni

Tissue specificityi

Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.1 Publication

Inductioni

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1148186, 1 interactor

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00930000151195
InParanoidiP0CJ75
PhylomeDBiP0CJ75

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MAPRGFSCLL LSTSEIDLPV KRRA
Length:24
Mass (Da):2,661
Last modified:February 8, 2011 - v1
Checksum:i08B9A778F4B0B971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021914 Genomic DNA No translation available.
CCDSiCCDS53602.1
RefSeqiNP_001177631.1, NM_001190702.1
UniGeneiHs.717003

Genome annotation databases

EnsembliENST00000536684; ENSP00000439666; ENSG00000255823
GeneIDi100463486
KEGGihsa:100463486
UCSCiuc001miq.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021914 Genomic DNA No translation available.
CCDSiCCDS53602.1
RefSeqiNP_001177631.1, NM_001190702.1
UniGeneiHs.717003

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1148186, 1 interactor

Polymorphism and mutation databases

BioMutaiMTRNR2L8

Proteomic databases

PaxDbiP0CJ75
PRIDEiP0CJ75
ProteomicsDBi52489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536684; ENSP00000439666; ENSG00000255823
GeneIDi100463486
KEGGihsa:100463486
UCSCiuc001miq.5 human

Organism-specific databases

CTDi100463486
EuPathDBiHostDB:ENSG00000255823.2
GeneCardsiMTRNR2L8
HGNCiHGNC:37165 MTRNR2L8
neXtProtiNX_P0CJ75
OpenTargetsiENSG00000255823
ENSG00000269028
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00930000151195
InParanoidiP0CJ75
PhylomeDBiP0CJ75

Miscellaneous databases

PROiPR:P0CJ75

Gene expression databases

BgeeiENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMN8_HUMAN
AccessioniPrimary (citable) accession number: P0CJ75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 7, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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