MTRNR2L8

Functionⁱ

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

GO - Molecular functionⁱ

receptor antagonist activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of execution phase of apoptosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Humanin-like 8Curated Short name: HN81 Publication Alternative name(s): MT-RNR2-like protein 8Imported
Gene namesⁱ	Name:MTRNR2L8Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000255823.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37165 MTRNR2L8
neXtProtⁱ	NX_P0CJ75

Keywords - Cellular componentⁱ

Cytoplasm, Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000255823 ENSG00000269028

OpenTargetsⁱ

ENSG00000255823
ENSG00000269028

Polymorphism and mutation databases

BioMutaⁱ	MTRNR2L8

BioMutaⁱ

MTRNR2L8

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000404557	1 – 24	Humanin-like 8Add BLAST		24

Proteomic databases

PaxDbⁱ	P0CJ75
PRIDEⁱ	P0CJ75
ProteomicsDBⁱ	52489

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.1 Publication

Inductionⁱ

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Bgeeⁱ

ENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Interactionⁱ

GO - Molecular functionⁱ

receptor antagonist activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	1148186, 1 interactor

BioGridⁱ

1148186, 1 interactor

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the humanin family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000151195
InParanoidⁱ	P0CJ75
PhylomeDBⁱ	P0CJ75

Family and domain databases

InterProⁱ	View protein in InterPro IPR028139 Humanin
PANTHERⁱ	PTHR33895 PTHR33895, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15040 Humanin, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P0CJ75-1 [UniParc]FASTA Add to basket

« Hide

        10         20 
MAPRGFSCLL LSTSEIDLPV KRRA

Length:24

Mass (Da):2,661

Last modified:February 8, 2011 - v1

Checksum:ⁱ08B9A778F4B0B971

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC021914 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53602.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001177631.1, NM_001190702.1
UniGeneⁱ	Hs.717003

Genome annotation databases

Ensemblⁱ	ENST00000536684; ENSP00000439666; ENSG00000255823
GeneIDⁱ	100463486
KEGGⁱ	hsa:100463486
UCSC genome browser More...UCSCⁱ	uc001miq.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0CJ75	Uncharacterized protein		PANTR		24	UniRef100_P0CJ75
Uncharacterized protein		PANPA		24

Protein	Similar proteins		Species	Score	Length	Source
P0CJ75	Humanin-like 1		HUMAN		24	UniRef90_P0CJ68
Uncharacterized protein		PANTR		24
Uncharacterized protein		PANPA		24
Uncharacterized protein (Fragment)		MACFA		23
Humanin-like 2		HUMAN		28
+2

Protein	Similar proteins		Species	Score	Length	Source
P0CJ75	Humanin-like 1		HUMAN		24	UniRef50_P0CJ68
Uncharacterized protein		PANTR		24
Uncharacterized protein		PANPA		24
Uncharacterized protein (Fragment)		MACFA		23
Uncharacterized protein		Klebsiella pneumoniae 30684/NJST258_2		35
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC021914 Genomic DNA No translation available.
CCDSⁱ	CCDS53602.1
RefSeqⁱ	NP_001177631.1, NM_001190702.1
UniGeneⁱ	Hs.717003

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1148186, 1 interactor

BioGridⁱ

1148186, 1 interactor

Polymorphism and mutation databases

BioMutaⁱ	MTRNR2L8

BioMutaⁱ

MTRNR2L8

Proteomic databases

PaxDbⁱ	P0CJ75
PRIDEⁱ	P0CJ75
ProteomicsDBⁱ	52489

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000536684; ENSP00000439666; ENSG00000255823
GeneIDⁱ	100463486
KEGGⁱ	hsa:100463486
UCSCⁱ	uc001miq.5 human

Organism-specific databases

CTDⁱ	100463486
EuPathDBⁱ	HostDB:ENSG00000255823.2
GeneCardsⁱ	MTRNR2L8
HGNCⁱ	HGNC:37165 MTRNR2L8
neXtProtⁱ	NX_P0CJ75
OpenTargetsⁱ	ENSG00000255823 ENSG00000269028
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00930000151195
InParanoidⁱ	P0CJ75
PhylomeDBⁱ	P0CJ75

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0CJ75

PROⁱ

PR:P0CJ75

Gene expression databases

Bgeeⁱ	ENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Bgeeⁱ

ENSG00000255823 Expressed in 91 organ(s), highest expression level in frontal cortex

Family and domain databases

InterProⁱ	View protein in InterPro IPR028139 Humanin
PANTHERⁱ	PTHR33895 PTHR33895, 1 hit
Pfamⁱ	View protein in Pfam PF15040 Humanin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMN8_HUMAN
Accessionⁱ	P0CJ75Primary (citable) accession number: P0CJ75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
	Last sequence update:	February 8, 2011
	Last modified:	November 7, 2018
	This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0CJ75 (HMN8_HUMAN)

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Humanin-like 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ