UniProtKB - P0CJ75 (HMN8_HUMAN)
Protein
Humanin-like 8
Gene
MTRNR2L8
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role as a neuroprotective and antiapoptotic factor.By similarity
Caution
The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication
GO - Molecular functioni
- receptor antagonist activity Source: GO_Central
GO - Biological processi
- negative regulation of execution phase of apoptosis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P0CJ75 |
Names & Taxonomyi
Protein namesi | Recommended name: Humanin-like 8CuratedShort name: HN81 Publication Alternative name(s): MT-RNR2-like protein 8Imported |
Gene namesi | Name:MTRNR2L8Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000255823.2 |
HGNCi | HGNC:37165, MTRNR2L8 |
neXtProti | NX_P0CJ75 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 100463486 |
OpenTargetsi | ENSG00000255823 ENSG00000269028 |
Miscellaneous databases
Pharosi | P0CJ75, Tdark |
Polymorphism and mutation databases
BioMutai | MTRNR2L8 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404557 | 1 – 24 | Humanin-like 8Add BLAST | 24 |
Proteomic databases
PaxDbi | P0CJ75 |
PRIDEi | P0CJ75 |
ProteomicsDBi | 52489 |
Expressioni
Tissue specificityi
Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.1 Publication
Inductioni
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication
Gene expression databases
Bgeei | ENSG00000255823, Expressed in frontal cortex and 115 other tissues |
Organism-specific databases
HPAi | ENSG00000255823, Tissue enhanced (blood, skeletal muscle) |
Interactioni
GO - Molecular functioni
- receptor antagonist activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 1148186, 2 interactors |
STRINGi | 9606.ENSP00000468991 |
Family & Domainsi
Sequence similaritiesi
Belongs to the humanin family.Curated
Phylogenomic databases
GeneTreei | ENSGT01010000222596 |
HOGENOMi | CLU_221584_0_0_1 |
InParanoidi | P0CJ75 |
PhylomeDBi | P0CJ75 |
Family and domain databases
InterProi | View protein in InterPro IPR028139, Humanin |
PANTHERi | PTHR33895, PTHR33895, 1 hit |
Pfami | View protein in Pfam PF15040, Humanin, 1 hit |
i Sequence
Sequence statusi: Complete.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021914 Genomic DNA No translation available. |
CCDSi | CCDS53602.1 |
RefSeqi | NP_001177631.1, NM_001190702.1 |
Genome annotation databases
Ensembli | ENST00000536684; ENSP00000439666; ENSG00000255823 |
GeneIDi | 100463486 |
KEGGi | hsa:100463486 |
UCSCi | uc001miq.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021914 Genomic DNA No translation available. |
CCDSi | CCDS53602.1 |
RefSeqi | NP_001177631.1, NM_001190702.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 1148186, 2 interactors |
STRINGi | 9606.ENSP00000468991 |
Polymorphism and mutation databases
BioMutai | MTRNR2L8 |
Proteomic databases
PaxDbi | P0CJ75 |
PRIDEi | P0CJ75 |
ProteomicsDBi | 52489 |
Genome annotation databases
Ensembli | ENST00000536684; ENSP00000439666; ENSG00000255823 |
GeneIDi | 100463486 |
KEGGi | hsa:100463486 |
UCSCi | uc001miq.5, human |
Organism-specific databases
CTDi | 100463486 |
DisGeNETi | 100463486 |
EuPathDBi | HostDB:ENSG00000255823.2 |
GeneCardsi | MTRNR2L8 |
HGNCi | HGNC:37165, MTRNR2L8 |
HPAi | ENSG00000255823, Tissue enhanced (blood, skeletal muscle) |
neXtProti | NX_P0CJ75 |
OpenTargetsi | ENSG00000255823 ENSG00000269028 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222596 |
HOGENOMi | CLU_221584_0_0_1 |
InParanoidi | P0CJ75 |
PhylomeDBi | P0CJ75 |
Enzyme and pathway databases
PathwayCommonsi | P0CJ75 |
Miscellaneous databases
BioGRID-ORCSi | 100463486, 265 hits in 472 CRISPR screens |
ChiTaRSi | MTRNR2L8, human |
Pharosi | P0CJ75, Tdark |
PROi | PR:P0CJ75 |
Gene expression databases
Bgeei | ENSG00000255823, Expressed in frontal cortex and 115 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR028139, Humanin |
PANTHERi | PTHR33895, PTHR33895, 1 hit |
Pfami | View protein in Pfam PF15040, Humanin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMN8_HUMAN | |
Accessioni | P0CJ75Primary (citable) accession number: P0CJ75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM