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Protein

Humanin-like 6

Gene

MTRNR2L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 6Curated
Short name:
HN61 Publication
Alternative name(s):
MT-RNR2-like protein 6Imported
Gene namesi
Name:MTRNR2L6Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000270672.1
HGNCiHGNC:37163 MTRNR2L6
neXtProtiNX_P0CJ73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000270672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045551 – 24Humanin-like 6Add BLAST24

Proteomic databases

PRIDEiP0CJ73
ProteomicsDBi52487

Expressioni

Tissue specificityi

Expressed in skeletal muscle and testis.1 Publication

Inductioni

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000270672 Expressed in 70 organ(s), highest expression level in heart

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149280
PhylomeDBiP0CJ73

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MTPRGFSCLL LPTSETDLPV KRRT
Length:24
Mass (Da):2,719
Last modified:February 8, 2011 - v1
Checksum:iFBE0A778F77FA270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231380 Genomic DNA No translation available.
CCDSiCCDS64784.1
RefSeqiNP_001177416.1, NM_001190487.2

Genome annotation databases

EnsembliENST00000604952; ENSP00000473686; ENSG00000270672
ENST00000633925; ENSP00000488809; ENSG00000282017
GeneIDi100463482
KEGGihsa:100463482
UCSCiuc003vzz.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231380 Genomic DNA No translation available.
CCDSiCCDS64784.1
RefSeqiNP_001177416.1, NM_001190487.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0CJ73
ProteomicsDBi52487

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000604952; ENSP00000473686; ENSG00000270672
ENST00000633925; ENSP00000488809; ENSG00000282017
GeneIDi100463482
KEGGihsa:100463482
UCSCiuc003vzz.3 human

Organism-specific databases

CTDi100463482
EuPathDBiHostDB:ENSG00000270672.1
GeneCardsiMTRNR2L6
HGNCiHGNC:37163 MTRNR2L6
neXtProtiNX_P0CJ73
OpenTargetsiENSG00000270672
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000149280
PhylomeDBiP0CJ73

Miscellaneous databases

PROiPR:P0CJ73

Gene expression databases

BgeeiENSG00000270672 Expressed in 70 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMN6_HUMAN
AccessioniPrimary (citable) accession number: P0CJ73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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