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Protein

Humanin-like 5

Gene

MTRNR2L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity1 Publication

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

GO - Biological processi

  • cellular response to staurosporine Source: UniProtKB
  • negative regulation of execution phase of apoptosis Source: UniProtKB
  • negative regulation of mitochondrial membrane permeability involved in apoptotic process Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 5Curated
Short name:
HN51 Publication
Alternative name(s):
MT-RNR2-like protein 5Imported
Gene namesi
Name:MTRNR2L5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000249860.3
HGNCiHGNC:37162 MTRNR2L5
neXtProtiNX_P0CJ72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000249860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045541 – 24Humanin-like 5Add BLAST24

Proteomic databases

PaxDbiP0CJ72
PRIDEiP0CJ72
ProteomicsDBi52486

Expressioni

Tissue specificityi

Expressed in testis and brain.1 Publication

Inductioni

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000249860

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000437910

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149280
InParanoidiP0CJ72
PhylomeDBiP0CJ72

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MATPGFSCLL LSTSEIDLPM KRRV
Length:24
Mass (Da):2,666
Last modified:February 8, 2011 - v1
Checksum:i17A9A778E35134B1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06454813T → I Decreased cytoprotective action. 1 PublicationCorresponds to variant dbSNP:rs11004928Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074322 Genomic DNA No translation available.
CCDSiCCDS53537.1
RefSeqiNP_001177407.1, NM_001190478.1
UniGeneiHs.727204

Genome annotation databases

EnsembliENST00000512524; ENSP00000437910; ENSG00000249860
GeneIDi100463289
KEGGihsa:100463289
UCSCiuc021pra.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHMN5_HUMAN
AccessioniPrimary (citable) accession number: P0CJ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: June 20, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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