Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Humanin-like 4

Gene

MTRNR2L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 4Curated
Short name:
HN41 Publication
Alternative name(s):
MT-RNR2-like protein 4Imported
Gene namesi
Name:MTRNR2L4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000232196.3
HGNCiHGNC:37161 MTRNR2L4
neXtProtiNX_P0CJ71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045531 – 28Humanin-like 4Add BLAST28

Proteomic databases

PaxDbiP0CJ71
PRIDEiP0CJ71
ProteomicsDBi52485

Expressioni

Tissue specificityi

Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain.1 Publication

Inductioni

Expression is not affected following staurosporine (STS) treatment. Down-regulated 6 hours following beta-carotene treatment, remains down-regulated 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000232196 Expressed in 60 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382856

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149280
InParanoidiP0CJ71

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MATQGFSCLL LSVSEIDLSM KRQYKQIR
Length:28
Mass (Da):3,247
Last modified:February 8, 2011 - v1
Checksum:i235503E7FE3B777A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025283 Genomic DNA No translation available.
CCDSiCCDS53985.1
RefSeqiNP_001177405.1, NM_001190476.1
UniGeneiHs.639648

Genome annotation databases

EnsembliENST00000399974; ENSP00000382856; ENSG00000232196
GeneIDi100463285
KEGGihsa:100463285
UCSCiuc021tce.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025283 Genomic DNA No translation available.
CCDSiCCDS53985.1
RefSeqiNP_001177405.1, NM_001190476.1
UniGeneiHs.639648

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382856

Proteomic databases

PaxDbiP0CJ71
PRIDEiP0CJ71
ProteomicsDBi52485

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399974; ENSP00000382856; ENSG00000232196
GeneIDi100463285
KEGGihsa:100463285
UCSCiuc021tce.2 human

Organism-specific databases

CTDi100463285
EuPathDBiHostDB:ENSG00000232196.3
GeneCardsiMTRNR2L4
HGNCiHGNC:37161 MTRNR2L4
neXtProtiNX_P0CJ71
OpenTargetsiENSG00000232196
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000149280
InParanoidiP0CJ71

Miscellaneous databases

GenomeRNAii100463285
PROiPR:P0CJ71

Gene expression databases

BgeeiENSG00000232196 Expressed in 60 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMN4_HUMAN
AccessioniPrimary (citable) accession number: P0CJ71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: September 12, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again