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Protein

Humanin-like 1

Gene

MTRNR2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

GO - Molecular functioni

  • receptor antagonist activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 1Curated
Short name:
HN11 Publication
Alternative name(s):
MT-RNR2-like protein 1Imported
Gene namesi
Name:MTRNR2L1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000256618.2
HGNCiHGNC:37155 MTRNR2L1
MIMi616985 gene
neXtProtiNX_P0CJ68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045501 – 24Humanin-like 1Add BLAST24

Proteomic databases

PaxDbiP0CJ68
PRIDEiP0CJ68
ProteomicsDBi52482

Expressioni

Tissue specificityi

Highly expressed in the kidney, heart muscle and testis.1 Publication

Inductioni

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000256618 Expressed in 84 organ(s), highest expression level in colon

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1148170, 9 interactors
STRINGi9606.ENSP00000439228

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00930000151195
OrthoDBiEOG09370QPH
PhylomeDBiP0CJ68

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
MAPRGFSCLL LSTSEIDLPV KRRT
Length:24
Mass (Da):2,691
Last modified:February 8, 2011 - v1
Checksum:i14C9A778F4B0B971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR612552 mRNA No translation available.
AC131055 Genomic DNA No translation available.
CCDSiCCDS54097.1
RefSeqiNP_001177381.1, NM_001190452.1
UniGeneiHs.740185

Genome annotation databases

EnsembliENST00000540040; ENSP00000439228; ENSG00000256618
GeneIDi100462977
KEGGihsa:100462977
UCSCiuc002gzb.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR612552 mRNA No translation available.
AC131055 Genomic DNA No translation available.
CCDSiCCDS54097.1
RefSeqiNP_001177381.1, NM_001190452.1
UniGeneiHs.740185

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1148170, 9 interactors
STRINGi9606.ENSP00000439228

Proteomic databases

PaxDbiP0CJ68
PRIDEiP0CJ68
ProteomicsDBi52482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540040; ENSP00000439228; ENSG00000256618
GeneIDi100462977
KEGGihsa:100462977
UCSCiuc002gzb.3 human

Organism-specific databases

CTDi100462977
EuPathDBiHostDB:ENSG00000256618.2
GeneCardsiMTRNR2L1
HGNCiHGNC:37155 MTRNR2L1
MIMi616985 gene
neXtProtiNX_P0CJ68
OpenTargetsiENSG00000256618
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00930000151195
OrthoDBiEOG09370QPH
PhylomeDBiP0CJ68

Miscellaneous databases

PROiPR:P0CJ68
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256618 Expressed in 84 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR028139 Humanin
PANTHERiPTHR33895 PTHR33895, 1 hit
PfamiView protein in Pfam
PF15040 Humanin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMN1_HUMAN
AccessioniPrimary (citable) accession number: P0CJ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 7, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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