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UniProtKB - P0CJ62 (RITA1_XENLA)
Protein
RBPJ-interacting and tubulin-associated protein 1
Gene
rita1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
1 PublicationGO - Molecular functioni
- tubulin binding Source: UniProtKB
GO - Biological processi
- negative regulation of Notch signaling pathway Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neurogenesis Source: UniProtKB
- Notch signaling pathway Source: UniProtKB-KW
- nuclear export Source: UniProtKB
Keywordsi
Biological process | Neurogenesis, Notch signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: RBPJ-interacting and tubulin-associated protein 1Alternative name(s): RBPJ-interacting and tubulin-associated protein |
Gene namesi | Name:rita1 Synonyms:rita |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 12 | L → A: Results in nuclear accumulation; when associated with A-14 and A-16. 1 Publication | 1 | |
Mutagenesisi | 14 | L → A: Results in nuclear accumulation; when associated with A-12 and A-16. 1 Publication | 1 | |
Mutagenesisi | 16 | I → A: Results in nuclear accumulation; when associated with A-12 and A-14. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404585 | 1 – 239 | RBPJ-interacting and tubulin-associated protein 1Add BLAST | 239 |
Interactioni
Subunit structurei
Interacts with rbpj/rbpsuh.
1 PublicationBinary interactionsi
P0CJ62
With | #Exp. | IntAct |
---|---|---|
RBPJ [Q06330] from Homo sapiens. | 2 | EBI-8517225,EBI-632552 |
GO - Molecular functioni
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
ELMi | P0CJ62 |
IntActi | P0CJ62, 2 interactors |
MINTi | P0CJ62 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 62 – 97 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 129 – 158 | Interaction with RBPJ/RBPSUHBy similarityAdd BLAST | 30 | |
Regioni | 149 – 239 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 158 – 239 | Interaction with tubulinBy similarityAdd BLAST | 82 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 12 – 24 | Nuclear export signalCuratedAdd BLAST | 13 | |
Motifi | 93 – 109 | Nuclear localization signalBy similarityAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 223 | Polar residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the RITA family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR031418, RITA1 |
PANTHERi | PTHR34917, PTHR34917, 1 hit |
Pfami | View protein in Pfam PF17066, RITA, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CJ62-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDNLYATNM SLDLSITGHS TALPQRKSRS TYRFKAANSY VDESLFGSSG
60 70 80 90 100
VRVDQTLQWN TAPPSQTPLL WSPGEIKENK KTSSCRPKST PAGTPRKKIQ
110 120 130 140 150
YRVKSRTPSY CDESLFGGKV EECTWDAPWV KKEDTVKIRP LLWSPSPRLV
160 170 180 190 200
QQSSMQNAKQ GPLRAVHPPE TSDSPLGTHK GLGAFWKPPE SDSDYSPSPF
210 220 230
SARQRQSTPG RETVRSASCS GRVTARRGSV KMQERPPWK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC070862 mRNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC070862 mRNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
ELMi | P0CJ62 |
IntActi | P0CJ62, 2 interactors |
MINTi | P0CJ62 |
Family and domain databases
InterProi | View protein in InterPro IPR031418, RITA1 |
PANTHERi | PTHR34917, PTHR34917, 1 hit |
Pfami | View protein in Pfam PF17066, RITA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RITA1_XENLA | |
Accessioni | P0CJ62Primary (citable) accession number: P0CJ62 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |