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Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

rita1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of Notch signaling pathway Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • neurogenesis Source: UniProtKB
  • Notch signaling pathway Source: UniProtKB-KW
  • nuclear export Source: UniProtKB

Keywordsi

Biological processNeurogenesis, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:rita1
Synonyms:rita
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12L → A: Results in nuclear accumulation; when associated with A-14 and A-16. 1 Publication1
Mutagenesisi14L → A: Results in nuclear accumulation; when associated with A-12 and A-16. 1 Publication1
Mutagenesisi16I → A: Results in nuclear accumulation; when associated with A-12 and A-14. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045851 – 239RBPJ-interacting and tubulin-associated protein 1Add BLAST239

Interactioni

Subunit structurei

Interacts with rbpj/rbpsuh.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPJQ063302EBI-8517225,EBI-632552From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

ELMiP0CJ62
IntActiP0CJ62, 2 interactors
MINTiP0CJ62

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 158Interaction with RBPJ/RBPSUHBy similarityAdd BLAST30
Regioni158 – 239Interaction with tubulinBy similarityAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 24Nuclear export signalCuratedAdd BLAST13
Motifi93 – 109Nuclear localization signalBy similarityAdd BLAST17

Sequence similaritiesi

Belongs to the RITA family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR031418 RITA1
PANTHERiPTHR34917 PTHR34917, 1 hit
PfamiView protein in Pfam
PF17066 RITA, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDNLYATNM SLDLSITGHS TALPQRKSRS TYRFKAANSY VDESLFGSSG
60 70 80 90 100
VRVDQTLQWN TAPPSQTPLL WSPGEIKENK KTSSCRPKST PAGTPRKKIQ
110 120 130 140 150
YRVKSRTPSY CDESLFGGKV EECTWDAPWV KKEDTVKIRP LLWSPSPRLV
160 170 180 190 200
QQSSMQNAKQ GPLRAVHPPE TSDSPLGTHK GLGAFWKPPE SDSDYSPSPF
210 220 230
SARQRQSTPG RETVRSASCS GRVTARRGSV KMQERPPWK
Length:239
Mass (Da):26,637
Last modified:February 8, 2011 - v1
Checksum:iD3EA216FC9371EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070862 mRNA No translation available.
UniGeneiXl.72480

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070862 mRNA No translation available.
UniGeneiXl.72480

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP0CJ62
IntActiP0CJ62, 2 interactors
MINTiP0CJ62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR031418 RITA1
PANTHERiPTHR34917 PTHR34917, 1 hit
PfamiView protein in Pfam
PF17066 RITA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRITA1_XENLA
AccessioniPrimary (citable) accession number: P0CJ62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: March 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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