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Protein

Putative fructose-bisphosphate aldolase

Gene

CIMG_05755

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (CIMG_07844)
  3. ATP-dependent 6-phosphofructokinase (CIMG_08879)
  4. Putative fructose-bisphosphate aldolase (CIMG_05755)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Proton donorBy similarity1
Metal bindingi87Zinc 1; catalyticBy similarity1
Metal bindingi116Zinc 2By similarity1
Metal bindingi146Zinc 2By similarity1
Metal bindingi192Zinc 1; catalyticBy similarity1
Binding sitei193Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi223Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Putative fructose-1,6-bisphosphate aldolase
Gene namesi
ORF Names:CIMG_05755
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_05755

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037871 – 302Putative fructose-bisphosphate aldolaseAdd BLAST302

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi246410.XP_001241859.1

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0CJ44
SMRiP0CJ44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CJ44

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 226Dihydroxyacetone phosphate bindingBy similarity3
Regioni245 – 248Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKER Eukaryota
KOG4153 Eukaryota
COG0191 LUCA
ENOG4111ZYV LUCA
InParanoidiP0CJ44
KOiK01624
OrthoDBiEOG092C3TYK

Family and domain databases

CDDicd00947 TBP_aldolase_IIB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit

Sequencei

Sequence statusi: Complete.

P0CJ44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHPSLKSNR ALPLLTFART HSFAIPAICV YNLEGILAII RAAEHKRSPA
60 70 80 90 100
MILLFPWAIQ YADSLLVRTA ASACRAASVP ITLHLDHAQD PEIIKRAADL
110 120 130 140 150
SRSETHEPGF DSIMVDMSHF SKEENLRLTR ELVAYCNARG IATEAEPGRI
160 170 180 190 200
EGGEDGVQDT VDLEGVLTTP EESEEFVATG INWLAPAFGN VHGNYGPRGV
210 220 230 240 250
QLDYERLQRI NEAVGERVGL VLHGADPFTK EIFEKCIERG VAKVNVNRAV
260 270 280 290 300
NNEYVKVMRE KAGSLPITRL HEEVTNAMQA AVEKIMDMID STGKAEFMMD

EK
Length:302
Mass (Da):33,389
Last modified:January 11, 2011 - v1
Checksum:i3FBF318A0A3421C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA Translation: EAS30276.3
RefSeqiXP_001241859.1, XM_001241858.2

Genome annotation databases

EnsemblFungiiEAS30276; EAS30276; CIMG_05755
GeneIDi4561677
KEGGicim:CIMG_05755

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA Translation: EAS30276.3
RefSeqiXP_001241859.1, XM_001241858.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PM6X-ray2.20A/B1-302[»]
ProteinModelPortaliP0CJ44
SMRiP0CJ44
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246410.XP_001241859.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAS30276; EAS30276; CIMG_05755
GeneIDi4561677
KEGGicim:CIMG_05755

Organism-specific databases

EuPathDBiFungiDB:CIMG_05755

Phylogenomic databases

eggNOGiENOG410IKER Eukaryota
KOG4153 Eukaryota
COG0191 LUCA
ENOG4111ZYV LUCA
InParanoidiP0CJ44
KOiK01624
OrthoDBiEOG092C3TYK

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Miscellaneous databases

EvolutionaryTraceiP0CJ44

Family and domain databases

CDDicd00947 TBP_aldolase_IIB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF_COCIM
AccessioniPrimary (citable) accession number: P0CJ44
Secondary accession number(s): J3K6Q1, J3K765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: March 15, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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