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Protein

Potassium channel toxin ImKTx88

Gene
N/A
Organism
Isometrus maculatus (Lesser brown scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recombinant toxin selectively inhibits Kv1.3/KCNA3 potassium channels with an IC50 of 91 pM.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei50Basic residue of the functional dyadBy similarity1
Sitei59Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin ImKTx88
OrganismiIsometrus maculatus (Lesser brown scorpion)
Taxonomic identifieri497827 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeIsometrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000040597623 – 60Potassium channel toxin ImKTx88Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 51By similarity
Disulfide bondi36 ↔ 56By similarity
Disulfide bondi40 ↔ 58By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiP0CJ24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CJ24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNFSVFLIA LLFCSVFILS EAQIYTSKEC NGSSECYSHC EGITGKRSGK
60
CINKKCYCYR
Length:60
Mass (Da):6,763
Last modified:March 8, 2011 - v1
Checksum:iF2852DA7169D73C5
GO

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0CJ24
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAX_ISOMC
AccessioniPrimary (citable) accession number: P0CJ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 22, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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