UniProtKB - P0CI78 (RL24_BACSU)
50S ribosomal protein L24
rplX
Functioni
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
By similarityOne of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
By similarityHas also been isolated as a basic, heat-shock stable DNA-binding protein from the B.subtilis nucleoid. It binds cooperatively to double-stranded supercoiled DNA which it further compacts into complexes 15-17 nm in diameter. Overexpression of the protein disrupts nucleoid segregation and positioning.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L24Alternative name(s): 12 kDa DNA-binding protein BL23 HPB12 |
Gene namesi | Name:rplX Ordered Locus Names:BSU01270 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
Other locations
- nucleoid Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000130623 | 1 – 103 | 50S ribosomal protein L24Add BLAST | 103 |
Proteomic databases
jPOSTi | P0CI78 |
PaxDbi | P0CI78 |
PRIDEi | P0CI78 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
1 PublicationProtein-protein interaction databases
IntActi | P0CI78, 1 interactor |
STRINGi | 224308.BSU01270 |
Structurei
Secondary structure
3D structure databases
SMRi | P0CI78 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0198, Bacteria |
InParanoidi | P0CI78 |
OMAi | HVKPTQE |
PhylomeDBi | P0CI78 |
Family and domain databases
CDDi | cd06089, KOW_RPL26, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
HAMAPi | MF_01326_B, Ribosomal_L24_B, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041988, KOW_RPL26/RPL24 IPR014722, Rib_L2_dom2 IPR003256, Ribosomal_L24 IPR005825, Ribosomal_L24/26_CS IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR12903, PTHR12903, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF17136, ribosomal_L24, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
TIGRFAMsi | TIGR01079, rplX_bact, 1 hit |
PROSITEi | View protein in PROSITE PS01108, RIBOSOMAL_L24, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MHVKKGDKVM VISGKDKGKQ GTILAAFPKK DRVLVEGVNM VKKHSKPTQA
60 70 80 90 100
NPQGGISNQE APIHVSNVMP LDPKTGEVTR VGYKVEDGKK VRVAKKSGQV
LDK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | Q → E AA sequence (PubMed:8282710).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15664 Genomic DNA Translation: CAA33702.1 M81748 Genomic DNA Translation: AAB59023.1 L47971 Genomic DNA Translation: AAB06810.1 AL009126 Genomic DNA Translation: CAB11903.1 |
PIRi | S05993, R5BS2B |
RefSeqi | NP_388008.1, NC_000964.3 WP_003156486.1, NZ_JNCM01000029.1 |
Genome annotation databases
EnsemblBacteriai | CAB11903; CAB11903; BSU_01270 |
GeneIDi | 64301965 66327852 936799 |
KEGGi | bsu:BSU01270 |
PATRICi | fig|224308.179.peg.130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15664 Genomic DNA Translation: CAA33702.1 M81748 Genomic DNA Translation: AAB59023.1 L47971 Genomic DNA Translation: AAB06810.1 AL009126 Genomic DNA Translation: CAB11903.1 |
PIRi | S05993, R5BS2B |
RefSeqi | NP_388008.1, NC_000964.3 WP_003156486.1, NZ_JNCM01000029.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J3V | electron microscopy | 13.30 | U | 1-103 | [»] | |
3J3W | electron microscopy | 10.70 | U | 1-103 | [»] | |
3J9W | electron microscopy | 3.90 | BX | 1-103 | [»] | |
5NJT | electron microscopy | 3.80 | n | 2-101 | [»] | |
6HA1 | electron microscopy | 3.10 | U | 1-103 | [»] | |
6HA8 | electron microscopy | 3.50 | U | 1-103 | [»] | |
6HTQ | electron microscopy | 4.50 | U | 1-101 | [»] | |
6PPF | electron microscopy | 3.40 | U | 1-103 | [»] | |
6PPK | electron microscopy | 4.40 | U | 1-103 | [»] | |
6PVK | electron microscopy | 3.40 | U | 1-103 | [»] | |
6TNN | electron microscopy | 3.07 | n | 1-103 | [»] | |
6TPQ | electron microscopy | 3.07 | n | 1-103 | [»] | |
7AQC | electron microscopy | 2.99 | U | 1-103 | [»] | |
7AQD | electron microscopy | 3.10 | U | 1-103 | [»] | |
7AS8 | electron microscopy | 2.90 | Y | 1-103 | [»] | |
7AS9 | electron microscopy | 3.50 | Y | 1-103 | [»] | |
7OPE | electron microscopy | 3.20 | Y | 1-103 | [»] | |
SMRi | P0CI78 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P0CI78, 1 interactor |
STRINGi | 224308.BSU01270 |
Proteomic databases
jPOSTi | P0CI78 |
PaxDbi | P0CI78 |
PRIDEi | P0CI78 |
Genome annotation databases
EnsemblBacteriai | CAB11903; CAB11903; BSU_01270 |
GeneIDi | 64301965 66327852 936799 |
KEGGi | bsu:BSU01270 |
PATRICi | fig|224308.179.peg.130 |
Phylogenomic databases
eggNOGi | COG0198, Bacteria |
InParanoidi | P0CI78 |
OMAi | HVKPTQE |
PhylomeDBi | P0CI78 |
Miscellaneous databases
PROi | PR:P0CI78 |
Family and domain databases
CDDi | cd06089, KOW_RPL26, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
HAMAPi | MF_01326_B, Ribosomal_L24_B, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041988, KOW_RPL26/RPL24 IPR014722, Rib_L2_dom2 IPR003256, Ribosomal_L24 IPR005825, Ribosomal_L24/26_CS IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR12903, PTHR12903, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF17136, ribosomal_L24, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
TIGRFAMsi | TIGR01079, rplX_bact, 1 hit |
PROSITEi | View protein in PROSITE PS01108, RIBOSOMAL_L24, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL24_BACSU | |
Accessioni | P0CI78Primary (citable) accession number: P0CI78 Secondary accession number(s): P12876 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2011 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 23, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families