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Protein

Dyslexia-associated protein KIAA0319 homolog

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.2 Publications

GO - Biological processi

  • negative regulation of dendrite development Source: GO_Central
  • neuron migration Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dyslexia-associated protein KIAA0319 homolog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1307443 RGD1307443

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 964ExtracellularSequence analysisAdd BLAST942
Transmembranei965 – 985HelicalSequence analysisAdd BLAST21
Topological domaini986 – 1081CytoplasmicSequence analysisAdd BLAST96

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000040347923 – 1081Dyslexia-associated protein KIAA0319 homologAdd BLAST1059

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated.By similarity
Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0CI71
PRIDEiP0CI71

Expressioni

Tissue specificityi

Highly expressed during development in ventricular zone, intermediate zone, cortical plate, striatum, hippocampus, and brain stem.

Gene expression databases

BgeeiENSRNOG00000018141 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP0CI71 RN

Interactioni

Subunit structurei

Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024536

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 99MANSCPROSITE-ProRule annotationAdd BLAST77
Domaini345 – 436PKD 1Add BLAST92
Domaini444 – 533PKD 2Add BLAST90
Domaini539 – 629PKD 3Add BLAST91
Domaini630 – 723PKD 4Add BLAST94
Domaini729 – 820PKD 5Add BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1004 – 1007Endocytosis signal4

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQB Eukaryota
ENOG410XQ5Y LUCA
GeneTreeiENSGT00880000137941
InParanoidiP0CI71
OMAiITKRCIC
OrthoDBiEOG091G016C
PhylomeDBiP0CI71

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR013980 MANSC_dom
IPR011106 MANSC_N
IPR022409 PKD/Chitinase_dom
IPR035986 PKD_dom_sf
SMARTiView protein in SMART
SM00765 MANEC, 1 hit
SM00089 PKD, 5 hits
SUPFAMiSSF49299 SSF49299, 4 hits
PROSITEiView protein in PROSITE
PS50986 MANSC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CI71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSPPGVLSS LLLLAAMAGG SSQQCSEGRT YSDAIISPNL ESIRIMRVSH
60 70 80 90 100
TFSVGDCTAA CCDLPSCDLA WWFEGSCYLV NCMRPENCEP RTTGPIRSYL
110 120 130 140 150
TFVRRPVQRS GQLLDYGDMM LGRGSPSGAW GDSLEDLRKD LPFLGKDGGP
160 170 180 190 200
EETAEYSDDY KELERGLLQP SNQQDPRGSA EYPDWSLLPS SDGDFNASAT
210 220 230 240 250
GDNSAASTEK LQDLTPYPLD QEQLQSLNES TWSPTPRHSE MSSMWPSSVT
260 270 280 290 300
ASPTEEGLEG EETLQLQEQP NNSSGKKVPM PSHNPSPASL ESSPTTVEKS
310 320 330 340 350
SIFTVTPWSR DPGTPTFPAS TVLPGLISPS WPLSPTTSRT VKALAVSAGD
360 370 380 390 400
NLVLTLPNGE AELKASVEPA PPADTAYTYE WSLMSHPVDF QGKIKQENKP
410 420 430 440 450
TLHLSQLSVG LYAFRVAVSG ENAFGEGYVN VTVMPAARIN QPPVAIVSPQ
460 470 480 490 500
IQELSLPLTS ALIDGSQSTD DAEIVSYHWE EVDGPFLGEA FLDDSPLLRL
510 520 530 540 550
SNLDPGNYTF RLTITDSDGA TNSTTAALII RGSLDYPPVA NAGPNQTITL
560 570 580 590 600
PQNTIILNGN QSSDDHQIVL YEWFPDPGGE SKEMVMQGAQ TPYLHLSELQ
610 620 630 640 650
EGEYTFQLMV TDSSGQQSTA LVTLTVQAEN NQAPVAVAGP DKELVFPVQS
660 670 680 690 700
AMLDGSRSSD DHGIVCYRWE HIRGPSAVEM ENVDKAIATV TGLQVGTYHF
710 720 730 740 750
RLTVRDQQGL SSTSTLTVAV KKENNSPPRA QAGGRHVLML PNNSITLDGS
760 770 780 790 800
RSTDDRGIVS YLWIRDGQSP AAGDIIGSSD NGAALQLTNL VEGVYTFHLL
810 820 830 840 850
VTDSQGASDS DTAIVEVLPD PKKDGMVELI LQVGVEQLTE QQKETLVRQL
860 870 880 890 900
AVLLNVLDSD VKVLKIQAHT DVSTVIVFYV QSGSPFKVLR AADVARNLHK
910 920 930 940 950
RLSKEKGAFL LFKVLRIDTA GCLLKCSGHG HCDPITKRCI CSQLWMENLL
960 970 980 990 1000
QRYMWDGESN CEWSVFYVAA LALTLTVLTG AVTWVCICCC RRRKRTKIRK
1010 1020 1030 1040 1050
KTKYTILDNM DEQERMELRP KYGIKHRSTE HNSSLMVSES EFESDQDTLF
1060 1070 1080
SQERMERGVL KGSLNGSARS GVSFGYYSKD R
Length:1,081
Mass (Da):118,013
Last modified:January 11, 2011 - v1
Checksum:i799EC97AC8303F79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104707 Genomic DNA No translation available.
RefSeqiNP_001183952.1, NM_001197023.1
XP_017456093.1, XM_017600604.1
UniGeneiRn.139250

Genome annotation databases

EnsembliENSRNOT00000024536; ENSRNOP00000024536; ENSRNOG00000018141
GeneIDi361244
KEGGirno:361244
UCSCiRGD:1307443 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03104707 Genomic DNA No translation available.
RefSeqiNP_001183952.1, NM_001197023.1
XP_017456093.1, XM_017600604.1
UniGeneiRn.139250

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024536

Proteomic databases

PaxDbiP0CI71
PRIDEiP0CI71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024536; ENSRNOP00000024536; ENSRNOG00000018141
GeneIDi361244
KEGGirno:361244
UCSCiRGD:1307443 rat

Organism-specific databases

CTDi361244
RGDi1307443 RGD1307443

Phylogenomic databases

eggNOGiENOG410IFQB Eukaryota
ENOG410XQ5Y LUCA
GeneTreeiENSGT00880000137941
InParanoidiP0CI71
OMAiITKRCIC
OrthoDBiEOG091G016C
PhylomeDBiP0CI71

Enzyme and pathway databases

ReactomeiR-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:P0CI71

Gene expression databases

BgeeiENSRNOG00000018141 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP0CI71 RN

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR013980 MANSC_dom
IPR011106 MANSC_N
IPR022409 PKD/Chitinase_dom
IPR035986 PKD_dom_sf
SMARTiView protein in SMART
SM00765 MANEC, 1 hit
SM00089 PKD, 5 hits
SUPFAMiSSF49299 SSF49299, 4 hits
PROSITEiView protein in PROSITE
PS50986 MANSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK0319_RAT
AccessioniPrimary (citable) accession number: P0CI71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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