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Entry version 54 (07 Oct 2020)
Sequence version 1 (30 Nov 2010)
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Protein

Pheromone alpha factor receptor

Gene

STE2

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the peptide pheromone alpha factor, the mating factor of yeast.By similarity

Miscellaneous

N-glycosylation may be involved in the sorting process for misfolded STE2 protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processPheromone response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pheromone alpha factor receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4932 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 73HelicalSequence analysisAdd BLAST23
Transmembranei80 – 102HelicalSequence analysisAdd BLAST23
Transmembranei133 – 155HelicalSequence analysisAdd BLAST23
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Transmembranei244 – 266HelicalSequence analysisAdd BLAST23
Transmembranei276 – 298HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004023831 – 431Pheromone alpha factor receptorAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi32N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei310PhosphoserineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei329PhosphothreonineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei363PhosphothreonineBy similarity1
Modified residuei366PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei382PhosphothreonineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei411PhosphothreonineBy similarity1
Modified residuei414PhosphothreonineBy similarity1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P0CI39, 23 interactors

Molecular INTeraction database

More...
MINTi
P0CI39

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P0CI39

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CI39

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CI39

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000366, GPCR_STE2
IPR027458, STE2_TM1-TM2_sf

The PANTHER Classification System

More...
PANTHERi
PTHR28009, PTHR28009, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02116, STE2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00250, GPCRSTE2

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CI39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT
60 70 80 90 100
QAIMFGVRCG AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK
110 120 130 140 150
YLLSNYSSVT YALTGFPQFI SRGDVHVYGA TNIIQVLLVA SIETSLVFQI
160 170 180 190 200
KVIFTGDNFK RIGLMLTSIS FTLGIATVTM YFVSAVKGMI VTYNDVSATQ
210 220 230 240 250
DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ FDSFHILLIM
260 270 280 290 300
SCQSLLVPSI IFILAYSLKP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN
310 320 330 340 350
NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR
360 370 380 390 400
RKETTSDKHS ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK
410 420 430
EGEVEPVDMY TPDTAADEEA RKFWTEDNNN L
Length:431
Mass (Da):47,849
Last modified:November 30, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i011F604DC2A6907E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti34S → T in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti176A → T in strain: CLIB 95, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti201D → G in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti294M → I in strain: CLIB 630 haplotype Ha2. 1 Publication1
Natural varianti337K → E in strain: CLIB 388, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2. 1 Publication1
Natural varianti370D → N in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17. 1 Publication1
Natural varianti394F → L in strain: R12 haplotype Ha2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ585737 Genomic DNA Translation: CAE52257.1
AJ585738 Genomic DNA Translation: CAE52258.1
AJ585739 Genomic DNA Translation: CAE52259.1
AJ585740 Genomic DNA Translation: CAE52260.1
AJ585741 Genomic DNA Translation: CAE52261.1
AJ585742 Genomic DNA Translation: CAE52262.1
AJ585743 Genomic DNA Translation: CAE52263.1
AJ585744 Genomic DNA Translation: CAE52264.1
AJ585745 Genomic DNA Translation: CAE52265.1
AJ585746 Genomic DNA Translation: CAE52266.1
AJ585747 Genomic DNA Translation: CAE52267.1
AJ585748 Genomic DNA Translation: CAE52268.1
AJ585749 Genomic DNA Translation: CAE52269.1
AJ585750 Genomic DNA Translation: CAE52270.1
AJ585751 Genomic DNA Translation: CAE52271.1
AJ585752 Genomic DNA Translation: CAE52272.1
AJ585753 Genomic DNA Translation: CAE52273.1
AJ585754 Genomic DNA Translation: CAE52274.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585737 Genomic DNA Translation: CAE52257.1
AJ585738 Genomic DNA Translation: CAE52258.1
AJ585739 Genomic DNA Translation: CAE52259.1
AJ585740 Genomic DNA Translation: CAE52260.1
AJ585741 Genomic DNA Translation: CAE52261.1
AJ585742 Genomic DNA Translation: CAE52262.1
AJ585743 Genomic DNA Translation: CAE52263.1
AJ585744 Genomic DNA Translation: CAE52264.1
AJ585745 Genomic DNA Translation: CAE52265.1
AJ585746 Genomic DNA Translation: CAE52266.1
AJ585747 Genomic DNA Translation: CAE52267.1
AJ585748 Genomic DNA Translation: CAE52268.1
AJ585749 Genomic DNA Translation: CAE52269.1
AJ585750 Genomic DNA Translation: CAE52270.1
AJ585751 Genomic DNA Translation: CAE52271.1
AJ585752 Genomic DNA Translation: CAE52272.1
AJ585753 Genomic DNA Translation: CAE52273.1
AJ585754 Genomic DNA Translation: CAE52274.1

3D structure databases

BMRBiP0CI39
SMRiP0CI39
ModBaseiSearch...

Protein-protein interaction databases

IntActiP0CI39, 23 interactors
MINTiP0CI39

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Phylogenomic databases

PhylomeDBiP0CI39

Family and domain databases

Gene3Di1.10.287.920, 1 hit
InterProiView protein in InterPro
IPR000366, GPCR_STE2
IPR027458, STE2_TM1-TM2_sf
PANTHERiPTHR28009, PTHR28009, 1 hit
PfamiView protein in Pfam
PF02116, STE2, 1 hit
PRINTSiPR00250, GPCRSTE2

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTE2_YEASX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CI39
Secondary accession number(s): P06842
, Q70D63, Q70D65, Q70D69, Q70D73, Q70D74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 7, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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