UniProtKB - P0CI34 (LDH_LACLM)
Protein
L-lactate dehydrogenase
Gene
ldh
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Functioni
Catalyzes the conversion of lactate to pyruvate.UniRule annotation
Catalytic activityi
- EC:1.1.1.27UniRule annotation
Activity regulationi
Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation
: pyruvate fermentation to lactate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (ldhX)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 16 | NAD; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 37 | NADUniRule annotation | 1 | |
Binding sitei | 42 | NADUniRule annotation | 1 | |
Binding sitei | 68 | NADUniRule annotation | 1 | |
Binding sitei | 85 | SubstrateUniRule annotation | 1 | |
Binding sitei | 91 | SubstrateUniRule annotation | 1 | |
Binding sitei | 104 | NADUniRule annotation | 1 | |
Binding sitei | 146 | NADUniRule annotation | 1 | |
Binding sitei | 156 | Allosteric activatorUniRule annotation | 1 | |
Binding sitei | 171 | Allosteric activatorUniRule annotation | 1 | |
Active sitei | 178 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 232 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 82 – 83 | NADUniRule annotation | 2 | |
Nucleotide bindingi | 121 – 123 | NADUniRule annotation | 3 |
GO - Molecular functioni
- L-lactate dehydrogenase activity Source: UniProtKB-UniRule
GO - Biological processi
- glycolytic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Allosteric enzyme, Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | LLAC416870:LLMG_RS02010-MONOMER |
SABIO-RKi | P0CI34 |
UniPathwayi | UPA00554;UER00611 |
Names & Taxonomyi
Protein namesi | Recommended name: L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)Short name: L-LDHUniRule annotation |
Gene namesi | Name:ldhUniRule annotation Synonyms:ldhB Ordered Locus Names:llmg_0392 |
Organismi | Lactococcus lactis subsp. cremoris (strain MG1363) |
Taxonomic identifieri | 416870 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285235 | 1 – 314 | L-lactate dehydrogenaseAdd BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 223 | PhosphotyrosineUniRule annotation | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Homotetramer.
UniRule annotationProtein-protein interaction databases
STRINGi | 416870.llmg_0392 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 123 – 126 | Substrate bindingUniRule annotation | 4 | |
Regioni | 151 – 154 | Substrate bindingUniRule annotation | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0039, Bacteria |
HOGENOMi | CLU_045401_1_1_9 |
OMAi | NLCRVHP |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CI34-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKITSRKVVV IGTGFVGTSI AYSMINQGLV NELVLIDVNQ DKAEGEALDL
60 70 80 90 100
LDGISWAQEN VIVRAGNYKD CENADIVVIT AGVNQKPGQS RLDLVNTNAK
110 120 130 140 150
IMRSIVTQVM DSGFDGIFVI ASNPVDILTY VAWETSGLDQ SRIVGTGTTL
160 170 180 190 200
DTTRFRKELA TKLEIDPRSV HGYIIGEHGD SEVAVWSHTT IGGKPILEFI
210 220 230 240 250
VKNKKIGLED LSNLSNKVKN AAYEIIDKKQ ATYYGIGMST ARIVKAILNN
260 270 280 290 300
EQVILPVSAY LRGEYGQEGV FTGVPSVVNQ NGVREIIELN IDAYEMKQFE
310
KSVSQLKEVI ESIK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM406671 Genomic DNA Translation: CAL96997.1 |
RefSeqi | WP_011834445.1, NZ_WJVF01000001.1 |
Genome annotation databases
EnsemblBacteriai | CAL96997; CAL96997; llmg_0392 |
KEGGi | llm:llmg_0392 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM406671 Genomic DNA Translation: CAL96997.1 |
RefSeqi | WP_011834445.1, NZ_WJVF01000001.1 |
3D structure databases
SMRi | P0CI34 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 416870.llmg_0392 |
Genome annotation databases
EnsemblBacteriai | CAL96997; CAL96997; llmg_0392 |
KEGGi | llm:llmg_0392 |
Phylogenomic databases
eggNOGi | COG0039, Bacteria |
HOGENOMi | CLU_045401_1_1_9 |
OMAi | NLCRVHP |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
BioCyci | LLAC416870:LLMG_RS02010-MONOMER |
SABIO-RKi | P0CI34 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LDH_LACLM | |
Accessioni | P0CI34Primary (citable) accession number: P0CI34 Secondary accession number(s): A2RIA3, Q7WYP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families