UniProtKB - P0CI31 (HCAB_ECOLI)
Protein
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase
Gene
hcaB
Organism
Escherichia coli (strain K12)
Status
Functioni
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.By similarity1 Publication
Catalytic activityi
- 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + H+ + NADH1 PublicationEC:1.3.1.871 Publication
- (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H+ + NADH1 PublicationEC:1.3.1.871 Publication
: 3-phenylpropanoate degradation Pathwayi
This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the pathway 3-phenylpropanoate degradation and in Aromatic compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 143 | SubstrateBy similarity | 1 | |
Active sitei | 156 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 34 | NADBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity Source: UniProtKB-UniRule
GO - Biological processi
- 3-phenylpropionate catabolic process Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Aromatic hydrocarbons catabolism |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:PHENPRODIOLDEHYDROG-MONOMER MetaCyc:PHENPRODIOLDEHYDROG-MONOMER |
UniPathwayi | UPA00714 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase (EC:1.3.1.87)Alternative name(s): 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase CI-dihydrodiol dehydrogenase Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase PP-dihydrodiol dehydrogenase |
Gene namesi | Name:hcaB Synonyms:phdD, yfhX Ordered Locus Names:b2541, JW2525 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054704 | 1 – 270 | 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenaseAdd BLAST | 270 |
Proteomic databases
PaxDbi | P0CI31 |
PRIDEi | P0CI31 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260604, 7 interactors |
DIPi | DIP-9863N |
IntActi | P0CI31, 7 interactors |
STRINGi | 511145.b2541 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_0_6 |
InParanoidi | P0CI31 |
PhylomeDBi | P0CI31 |
Family and domain databases
HAMAPi | MF_01647, HcaB, 1 hit |
InterProi | View protein in InterPro IPR023643, Dihydrodiol_DH_HcaB IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CI31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDLHNESIF ITGGGSGLGL ALVERFIEEG AQVATLELSA AKVASLRQRF
60 70 80 90 100
GEHILAVEGN VTCYADYQRA VDQILTRSGK LDCFIGNAGI WDHNASLVNT
110 120 130 140 150
PAETLETGFH ELFNVNVLGY LLGAKACAPA LIASEGSMIF TLSNAAWYPG
160 170 180 190 200
GGGPLYTASK HAATGLIRQL AYELAPKVRV NGVGPCGMAS DLRGPQALGQ
210 220 230 240 250
SETSIMQSLT PEKIAAILPL QFFPQPADFT GPYVMLTSRR NNRALSGVMI
260 270
NADAGLAIRG IRHVAAGLDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75594.1 AP009048 Genomic DNA Translation: BAA16444.1 |
PIRi | D65031 |
RefSeqi | NP_417036.1, NC_000913.3 WP_001281379.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75594; AAC75594; b2541 BAA16444; BAA16444; BAA16444 |
GeneIDi | 57732357 945346 |
KEGGi | ecj:JW2525 eco:b2541 |
PATRICi | fig|1411691.4.peg.4193 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75594.1 AP009048 Genomic DNA Translation: BAA16444.1 |
PIRi | D65031 |
RefSeqi | NP_417036.1, NC_000913.3 WP_001281379.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0CI31 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260604, 7 interactors |
DIPi | DIP-9863N |
IntActi | P0CI31, 7 interactors |
STRINGi | 511145.b2541 |
Proteomic databases
PaxDbi | P0CI31 |
PRIDEi | P0CI31 |
Genome annotation databases
EnsemblBacteriai | AAC75594; AAC75594; b2541 BAA16444; BAA16444; BAA16444 |
GeneIDi | 57732357 945346 |
KEGGi | ecj:JW2525 eco:b2541 |
PATRICi | fig|1411691.4.peg.4193 |
Organism-specific databases
EchoBASEi | EB3232 |
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_0_6 |
InParanoidi | P0CI31 |
PhylomeDBi | P0CI31 |
Enzyme and pathway databases
UniPathwayi | UPA00714 |
BioCyci | EcoCyc:PHENPRODIOLDEHYDROG-MONOMER MetaCyc:PHENPRODIOLDEHYDROG-MONOMER |
Miscellaneous databases
PROi | PR:P0CI31 |
Family and domain databases
HAMAPi | MF_01647, HcaB, 1 hit |
InterProi | View protein in InterPro IPR023643, Dihydrodiol_DH_HcaB IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HCAB_ECOLI | |
Accessioni | P0CI31Primary (citable) accession number: P0CI31 Secondary accession number(s): P76995, P77646 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families