UniProtKB - P0CI26 (TR49C_HUMAN)
Protein
Tripartite motif-containing protein 49C
Gene
TRIM49C
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 49CAlternative name(s): Tripartite motif-containing protein 49-like protein 2 |
Gene namesi | Name:TRIM49C Synonyms:TRIM49L2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204449.3 |
HGNCi | HGNC:38877 TRIM49C |
neXtProti | NX_P0CI26 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000204449 |
Polymorphism and mutation databases
BioMutai | TRIM49C |
DMDMi | 310947306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000399992 | 1 – 452 | Tripartite motif-containing protein 49CAdd BLAST | 452 |
Proteomic databases
PaxDbi | P0CI26 |
PeptideAtlasi | P0CI26 |
PRIDEi | P0CI26 |
ProteomicsDBi | 52481 |
PTM databases
iPTMneti | P0CI26 |
PhosphoSitePlusi | P0CI26 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204449 Expressed in 1 organ(s), highest expression level in esophagus mucosa |
Genevisiblei | P0CI26 HS |
Interactioni
Protein-protein interaction databases
IntActi | P0CI26, 3 interactors |
STRINGi | 9606.ENSP00000388299 |
Structurei
3D structure databases
ProteinModelPortali | P0CI26 |
SMRi | P0CI26 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 269 – 452 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 184 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177 Eukaryota ENOG4111G04 LUCA |
GeneTreei | ENSGT00940000165665 |
InParanoidi | P0CI26 |
KOi | K12019 |
OMAi | WEEACEN |
OrthoDBi | 565446at2759 |
PhylomeDBi | P0CI26 |
TreeFami | TF338674 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit |
PRINTSi | PR01407 BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336 BBOX, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit |
SUPFAMi | SSF49899 SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CI26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV
60 70 80 90 100
QCSECTKSTE QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK
110 120 130 140 150
KIFCEVDRSL LCLLCSSSQE HRYHRHRPIE WAAEEHREKL LQKMQSLWEK
160 170 180 190 200
ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM
210 220 230 240 250
LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP DVELLQAFGD
260 270 280 290 300
ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
310 320 330 340 350
FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS
360 370 380 390 400
WNWAFGVCNM YRKEKNQNEK IDGKEGLFLL GCIKNDIQCS LFTTSPLMLQ
410 420 430 440 450
YIPKPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI
HF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004607 Genomic DNA No translation available. BC126470 mRNA Translation: AAI26471.1 |
CCDSi | CCDS53694.1 |
RefSeqi | NP_001182163.1, NM_001195234.1 |
UniGenei | Hs.740080 |
Genome annotation databases
Ensembli | ENST00000448984; ENSP00000388299; ENSG00000204449 |
GeneIDi | 642612 |
KEGGi | hsa:642612 |
UCSCi | uc010rua.2 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP004607 Genomic DNA No translation available. BC126470 mRNA Translation: AAI26471.1 |
CCDSi | CCDS53694.1 |
RefSeqi | NP_001182163.1, NM_001195234.1 |
UniGenei | Hs.740080 |
3D structure databases
ProteinModelPortali | P0CI26 |
SMRi | P0CI26 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | P0CI26, 3 interactors |
STRINGi | 9606.ENSP00000388299 |
PTM databases
iPTMneti | P0CI26 |
PhosphoSitePlusi | P0CI26 |
Polymorphism and mutation databases
BioMutai | TRIM49C |
DMDMi | 310947306 |
Proteomic databases
PaxDbi | P0CI26 |
PeptideAtlasi | P0CI26 |
PRIDEi | P0CI26 |
ProteomicsDBi | 52481 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000448984; ENSP00000388299; ENSG00000204449 |
GeneIDi | 642612 |
KEGGi | hsa:642612 |
UCSCi | uc010rua.2 human |
Organism-specific databases
CTDi | 642612 |
EuPathDBi | HostDB:ENSG00000204449.3 |
GeneCardsi | TRIM49C |
HGNCi | HGNC:38877 TRIM49C |
neXtProti | NX_P0CI26 |
OpenTargetsi | ENSG00000204449 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177 Eukaryota ENOG4111G04 LUCA |
GeneTreei | ENSGT00940000165665 |
InParanoidi | P0CI26 |
KOi | K12019 |
OMAi | WEEACEN |
OrthoDBi | 565446at2759 |
PhylomeDBi | P0CI26 |
TreeFami | TF338674 |
Miscellaneous databases
GenomeRNAii | 642612 |
PROi | PR:P0CI26 |
Gene expression databases
Bgeei | ENSG00000204449 Expressed in 1 organ(s), highest expression level in esophagus mucosa |
Genevisiblei | P0CI26 HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit |
PRINTSi | PR01407 BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336 BBOX, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit |
SUPFAMi | SSF49899 SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TR49C_HUMAN | |
Accessioni | P0CI26Primary (citable) accession number: P0CI26 Secondary accession number(s): A0AVR7 Q9NS80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2010 |
Last sequence update: | November 2, 2010 | |
Last modified: | January 16, 2019 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM