UniProtKB - P0CI25 (TRI49_HUMAN)
Protein
Tripartite motif-containing protein 49
Gene
TRIM49
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: GO_Central
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P0CI25 |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 49Alternative name(s): RING finger protein 18 Testis-specific RING-finger protein |
Gene namesi | Name:TRIM49 Synonyms:RNF18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168930.13 |
HGNCi | HGNC:13431, TRIM49 |
MIMi | 606124, gene |
neXtProti | NX_P0CI25 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000168930 |
Miscellaneous databases
Pharosi | P0CI25, Tdark |
Polymorphism and mutation databases
BioMutai | TRIM49 |
DMDMi | 310947307 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056273 | 1 – 452 | Tripartite motif-containing protein 49Add BLAST | 452 |
Proteomic databases
MassIVEi | P0CI25 |
PaxDbi | P0CI25 |
PeptideAtlasi | P0CI25 |
PRIDEi | P0CI25 |
ProteomicsDBi | 52480 |
PTM databases
iPTMneti | P0CI25 |
PhosphoSitePlusi | P0CI25 |
Expressioni
Tissue specificityi
Preferentially expressed in testis.
Gene expression databases
Bgeei | ENSG00000168930, Expressed in sural nerve and 9 other tissues |
ExpressionAtlasi | P0CI25, baseline and differential |
Genevisiblei | P0CI25, HS |
Organism-specific databases
HPAi | ENSG00000168930, Tissue enhanced (blood, testis) |
Interactioni
Binary interactionsi
Hide detailsP0CI25
With | #Exp. | IntAct |
---|---|---|
CKS1B [P61024] | 4 | EBI-6427421,EBI-456371 |
MINDY3 [Q9H8M7] | 6 | EBI-6427421,EBI-724928 |
POM121 - isoform 2 [Q96HA1-2] | 3 | EBI-6427421,EBI-11956563 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121361, 9 interactors |
IntActi | P0CI25, 5 interactors |
STRINGi | 9606.ENSP00000327604 |
Miscellaneous databases
RNActi | P0CI25, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 269 – 452 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 184 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000165665 |
InParanoidi | P0CI25 |
OMAi | HNERVTH |
OrthoDBi | 565446at2759 |
PhylomeDBi | P0CI25 |
TreeFami | TF338674 |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P0CI25-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV
60 70 80 90 100
QCSECTKSTE QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK
110 120 130 140 150
KIFCEVDRSL LCLLCSSSQE HRYHRHRPIE WAAEEHREKL LQKMQSLWEK
160 170 180 190 200
ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM
210 220 230 240 250
LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP DVELLQAFGD
260 270 280 290 300
ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANNDI
310 320 330 340 350
FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS
360 370 380 390 400
WNWAFGVCNM YRKEKNQNEK IDGKAGLFLL GCVKNDIQCS LFTTSPLMLQ
410 420 430 440 450
YIPKPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI
HF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PK69 | E9PK69_HUMAN | Tripartite motif-containing protein... | TRIM49 | 375 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 298 | N → S in AAH75019 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 298 | N → S in AAH75020 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061824 | 373 | G → R. Corresponds to variant dbSNP:rs12417980Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037682 mRNA Translation: BAB03503.1 AP004607 Genomic DNA No translation available. BC075019 mRNA Translation: AAH75019.1 BC075020 mRNA Translation: AAH75020.1 BC126472 mRNA Translation: AAI26473.1 |
CCDSi | CCDS8287.1 |
RefSeqi | NP_065091.1, NM_020358.2 |
Genome annotation databases
Ensembli | ENST00000329758; ENSP00000327604; ENSG00000168930 |
GeneIDi | 57093 |
KEGGi | hsa:57093 |
UCSCi | uc001pdb.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037682 mRNA Translation: BAB03503.1 AP004607 Genomic DNA No translation available. BC075019 mRNA Translation: AAH75019.1 BC075020 mRNA Translation: AAH75020.1 BC126472 mRNA Translation: AAI26473.1 |
CCDSi | CCDS8287.1 |
RefSeqi | NP_065091.1, NM_020358.2 |
3D structure databases
SMRi | P0CI25 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121361, 9 interactors |
IntActi | P0CI25, 5 interactors |
STRINGi | 9606.ENSP00000327604 |
PTM databases
iPTMneti | P0CI25 |
PhosphoSitePlusi | P0CI25 |
Polymorphism and mutation databases
BioMutai | TRIM49 |
DMDMi | 310947307 |
Proteomic databases
MassIVEi | P0CI25 |
PaxDbi | P0CI25 |
PeptideAtlasi | P0CI25 |
PRIDEi | P0CI25 |
ProteomicsDBi | 52480 |
Protocols and materials databases
Antibodypediai | 31517, 155 antibodies |
DNASUi | 57093 |
Genome annotation databases
Ensembli | ENST00000329758; ENSP00000327604; ENSG00000168930 |
GeneIDi | 57093 |
KEGGi | hsa:57093 |
UCSCi | uc001pdb.3, human |
Organism-specific databases
CTDi | 57093 |
EuPathDBi | HostDB:ENSG00000168930.13 |
GeneCardsi | TRIM49 |
HGNCi | HGNC:13431, TRIM49 |
HPAi | ENSG00000168930, Tissue enhanced (blood, testis) |
MIMi | 606124, gene |
neXtProti | NX_P0CI25 |
OpenTargetsi | ENSG00000168930 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000165665 |
InParanoidi | P0CI25 |
OMAi | HNERVTH |
OrthoDBi | 565446at2759 |
PhylomeDBi | P0CI25 |
TreeFami | TF338674 |
Enzyme and pathway databases
PathwayCommonsi | P0CI25 |
Miscellaneous databases
BioGRID-ORCSi | 57093, 78 hits in 432 CRISPR screens |
GenomeRNAii | 57093 |
Pharosi | P0CI25, Tdark |
PROi | PR:P0CI25 |
RNActi | P0CI25, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168930, Expressed in sural nerve and 9 other tissues |
ExpressionAtlasi | P0CI25, baseline and differential |
Genevisiblei | P0CI25, HS |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI49_HUMAN | |
Accessioni | P0CI25Primary (citable) accession number: P0CI25 Secondary accession number(s): A0AVR7 Q9NS80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2010 |
Last sequence update: | November 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations