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Protein

Zinc finger protein 705D

Gene

ZNF705D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 705D
Gene namesi
Name:ZNF705D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000215343.7
HGNCiHGNC:33202 ZNF705D
neXtProtiNX_P0CH99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215343

Polymorphism and mutation databases

BioMutaiZNF705D
DMDMi308191622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322361 – 300Zinc finger protein 705DAdd BLAST300

Proteomic databases

PaxDbiP0CH99
PeptideAtlasiP0CH99
PRIDEiP0CH99
ProteomicsDBi52477

Expressioni

Gene expression databases

BgeeiENSG00000215343

Interactioni

Protein-protein interaction databases

IntActiP0CH99, 1 interactor
STRINGi9606.ENSP00000382957

Structurei

3D structure databases

ProteinModelPortaliP0CH99
SMRiP0CH99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00830000128291
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP0CH99
KOiK09228
OMAiHERTHMK
OrthoDBiEOG091G0C5V
PhylomeDBiP0CH99
TreeFamiTF338497

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

P0CH99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLEKVTFE DVAIDFTQEE WDMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWREGR VFLQDQNPDR ESALKKKHMI SMHPIIRKDA
110 120 130 140 150
STSMTMENSL ILEDPFEYND SGEDCTHSST ITQCLLTHSG KKPCVSKQCG
160 170 180 190 200
KSLRNLLSPK PRKQIHTKGK SYQCNLCEKA YTNCFYLRRH KMTHTGERPY
210 220 230 240 250
ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS FNLRRHERTH
260 270 280 290 300
LGQKCYECDK SGKAFSQSSG FRGNKIIHIG EKPHACLLCG KAFSLSSDLR
Length:300
Mass (Da):34,712
Last modified:October 5, 2010 - v1
Checksum:i1E1C943AF352977B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144C → Y in AAI10824 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA No translation available.
BC110823 mRNA Translation: AAI10824.1
CCDSiCCDS43712.1
RefSeqiNP_001034704.2, NM_001039615.3
XP_011542134.1, XM_011543832.2
UniGeneiHs.652228

Genome annotation databases

EnsembliENST00000400078; ENSP00000445477; ENSG00000215343
ENST00000400085; ENSP00000382957; ENSG00000215343
GeneIDi728957
KEGGihsa:728957
UCSCiuc064kiq.1 human

Similar proteinsi

Entry informationi

Entry nameiZ705D_HUMAN
AccessioniPrimary (citable) accession number: P0CH99
Secondary accession number(s): A8K971, A8MY01, Q2TAN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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