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Protein

Phospholipase A1

Gene
N/A
Organism
Vespula squamosa (Southern yellow jacket) (Wasp)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134NucleophileBy similarity1
Active sitei162Charge relay systemPROSITE-ProRule annotation1
Active sitei227Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCytolysis, Hemolysis, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 (EC:3.1.1.32)
Alternative name(s):
Allergen: Ves s 1
OrganismiVespula squamosa (Southern yellow jacket) (Wasp)
Taxonomic identifieri30214 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3518 Ves s 1.0101
665 Ves s 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004019211 – 298Phospholipase A1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 242By similarity
Disulfide bondi87 ↔ 225By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 216By similarity
Disulfide bondi178 ↔ 259By similarity
Disulfide bondi237 ↔ 243By similarity
Disulfide bondi266 ↔ 291By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002334 Allerg_PlipaseA1
IPR013818 Lipase/vitellogenin
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PRINTSiPR00825 DOLALLERGEN
PR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P0CH86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GSKCPFSDDT VAMVIVTREN RNRDFYTLQT LRNHDEFKKK AITRPVVFIT
60 70 80 90 100
HGFTSSATVE SFVDLQTAIL EXXXXKVTVS DWRVAACNRT TGLLYYVTAV
110 120 130 140 150
SNTRLVGRYI ATVTKKLVTD YNVSMADIRL IGHSLGAHVS GFAGKEVQKL
160 170 180 190 200
KLEKYSEIIG LDPAGPSFES NDCAERLCKT DAHYVQIIHT SKKFGIEKSI
210 220 230 240 250
GHVDFYVNQG NNQPGCGIIP LKDVCSHSRA ITYMTECIKR ECCLIGIPQS
260 270 280 290
KSSKSISSCT RQECVCVGLK AKSYPNTGSF YVPVESTAPF CNNKGKII
Length:298
Mass (Da):32,934
Last modified:November 30, 2010 - v1
Checksum:iAAC3822E61263EEF
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3518 Ves s 1.0101
665 Ves s 1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002334 Allerg_PlipaseA1
IPR013818 Lipase/vitellogenin
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PRINTSiPR00825 DOLALLERGEN
PR00821 TAGLIPASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA1_VESSQ
AccessioniPrimary (citable) accession number: P0CH86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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