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Entry version 46 (08 May 2019)
Sequence version 1 (10 Aug 2010)
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Protein

Polyubiquitin-F

Gene

ubqF

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).By similarity

Miscellaneous

Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein. In D.discoideum there are 9 genes: ubqA: 5 copies of Ub and a final Asn; ubqB: 1 copy of Ub and ribosomal protein L40; ubqC: 1 copy of Ub and ribosomal protein S27A; ubqD: 3 copies of Ub and a final Leu; ubqF: 7 copies of Ub and a final Asn; ubqG: 5 copies of Ub and a final Leu; ubqH: 5 copies of Ub and a final Asn; ubqI: 4 copies of Ub and a final Asn; ubqJ: 4 copies of Ub and a final Asn.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein tag Source: GO_Central
  • ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-110312 Translesion synthesis by REV1
R-DDI-110314 Recognition of DNA damage by PCNA-containing replication complex
R-DDI-1169408 ISG15 antiviral mechanism
R-DDI-1358803 Downregulation of ERBB2:ERBB3 signaling
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154 APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
R-DDI-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813 Separation of Sister Chromatids
R-DDI-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DDI-3134975 Regulation of innate immune responses to cytosolic DNA
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258 Degradation of DVL
R-DDI-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-DDI-5358346 Hedgehog ligand biogenesis
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5655862 Translesion synthesis by POLK
R-DDI-5656121 Translesion synthesis by POLI
R-DDI-5656169 Termination of translesion DNA synthesis
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5675221 Negative regulation of MAPK pathway
R-DDI-5687128 MAPK6/MAPK4 signaling
R-DDI-5689603 UCH proteinases
R-DDI-5689877 Josephin domain DUBs
R-DDI-5689880 Ub-specific processing proteases
R-DDI-5689901 Metalloprotease DUBs
R-DDI-5696394 DNA Damage Recognition in GG-NER
R-DDI-5696395 Formation of Incision Complex in GG-NER
R-DDI-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-DDI-6781823 Formation of TC-NER Pre-Incision Complex
R-DDI-6782135 Dual incision in TC-NER
R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-6804756 Regulation of TP53 Activity through Phosphorylation
R-DDI-6804757 Regulation of TP53 Degradation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69231 Cyclin D associated events in G1
R-DDI-69541 Stabilization of p53
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DDI-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-DDI-8948747 Regulation of PTEN localization
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-901032 ER Quality Control Compartment (ERQC)
R-DDI-9020702 Interleukin-1 signaling
R-DDI-9033241 Peroxisomal protein import
R-DDI-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-DDI-917937 Iron uptake and transport
R-DDI-936440 Negative regulators of DDX58/IFIH1 signaling
R-DDI-937042 IRAK2 mediated activation of TAK1 complex
R-DDI-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-DDI-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyubiquitin-F
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ubqF
ORF Names:DDB_G0289449
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0289449 ubqF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003963211 – 76UbiquitinAdd BLAST76
ChainiPRO_000039632277 – 152UbiquitinAdd BLAST76
ChainiPRO_0000396323153 – 228UbiquitinAdd BLAST76
ChainiPRO_0000396324229 – 304UbiquitinAdd BLAST76
ChainiPRO_0000396325305 – 380UbiquitinAdd BLAST76
ChainiPRO_0000396326381 – 456UbiquitinAdd BLAST76
ChainiPRO_0000396327457 – 532UbiquitinAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00003963285331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CG78

PRoteomics IDEntifications database

More...
PRIDEi
P0CG78

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0201651

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CG78

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 76Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST76
Domaini77 – 152Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST76
Domaini153 – 228Ubiquitin-like 3PROSITE-ProRule annotationAdd BLAST76
Domaini229 – 304Ubiquitin-like 4PROSITE-ProRule annotationAdd BLAST76
Domaini305 – 380Ubiquitin-like 5PROSITE-ProRule annotationAdd BLAST76
Domaini381 – 456Ubiquitin-like 6PROSITE-ProRule annotationAdd BLAST76
Domaini457 – 532Ubiquitin-like 7PROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0001 Eukaryota
COG5272 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CG78

KEGG Orthology (KO)

More...
KOi
K08770

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPMERIM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CG78

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00240 ubiquitin, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00348 UBIQUITIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00213 UBQ, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00299 UBIQUITIN_1, 7 hits
PS50053 UBIQUITIN_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQIFVKTLTG KTITLEVEGS DNIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEGSDNIE
110 120 130 140 150
NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR
160 170 180 190 200
GGMQIFVKTL TGKTITLEVE GSDNIENVKA KIQDKEGIPP DQQRLIFAGK
210 220 230 240 250
QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEGSDN
260 270 280 290 300
IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
310 320 330 340 350
LRGGMQIFVK TLTGKTITLE VEGSDNIENV KAKIQDKEGI PPDQQRLIFA
360 370 380 390 400
GKQLEDGRTL SDYNIQKEST LHLVLRLRGG MQIFVKTLTG KTITLEVEGS
410 420 430 440 450
DNIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV
460 470 480 490 500
LRLRGGMQIF VKTLTGKTIT LEVEGSDNIE NVKAKIQDKE GIPPDQQRLI
510 520 530
FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGN
Length:533
Mass (Da):59,770
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86BCCCD5679DAE1F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23753 mRNA Translation: AAA33267.1
AAFI02000141 Genomic DNA Translation: EAL62704.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A34080

NCBI Reference Sequences

More...
RefSeqi
XP_636210.1, XM_631118.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL62704; EAL62704; DDB_G0289449

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627148

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0289449

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23753 mRNA Translation: AAA33267.1
AAFI02000141 Genomic DNA Translation: EAL62704.1
PIRiA34080
RefSeqiXP_636210.1, XM_631118.1

3D structure databases

SMRiP0CG78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0201651

Proteomic databases

PaxDbiP0CG78
PRIDEiP0CG78

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62704; EAL62704; DDB_G0289449
GeneIDi8627148
KEGGiddi:DDB_G0289449

Organism-specific databases

dictyBaseiDDB_G0289449 ubqF

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
COG5272 LUCA
InParanoidiP0CG78
KOiK08770
OMAiCPMERIM
PhylomeDBiP0CG78

Enzyme and pathway databases

ReactomeiR-DDI-110312 Translesion synthesis by REV1
R-DDI-110314 Recognition of DNA damage by PCNA-containing replication complex
R-DDI-1169408 ISG15 antiviral mechanism
R-DDI-1358803 Downregulation of ERBB2:ERBB3 signaling
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174154 APC/C:Cdc20 mediated degradation of Securin
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
R-DDI-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DDI-2467813 Separation of Sister Chromatids
R-DDI-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DDI-3134975 Regulation of innate immune responses to cytosolic DNA
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-4641258 Degradation of DVL
R-DDI-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-DDI-5358346 Hedgehog ligand biogenesis
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5655862 Translesion synthesis by POLK
R-DDI-5656121 Translesion synthesis by POLI
R-DDI-5656169 Termination of translesion DNA synthesis
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5675221 Negative regulation of MAPK pathway
R-DDI-5687128 MAPK6/MAPK4 signaling
R-DDI-5689603 UCH proteinases
R-DDI-5689877 Josephin domain DUBs
R-DDI-5689880 Ub-specific processing proteases
R-DDI-5689901 Metalloprotease DUBs
R-DDI-5696394 DNA Damage Recognition in GG-NER
R-DDI-5696395 Formation of Incision Complex in GG-NER
R-DDI-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-DDI-6781823 Formation of TC-NER Pre-Incision Complex
R-DDI-6782135 Dual incision in TC-NER
R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-6804756 Regulation of TP53 Activity through Phosphorylation
R-DDI-6804757 Regulation of TP53 Degradation
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69231 Cyclin D associated events in G1
R-DDI-69541 Stabilization of p53
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DDI-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-DDI-8948747 Regulation of PTEN localization
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-901032 ER Quality Control Compartment (ERQC)
R-DDI-9020702 Interleukin-1 signaling
R-DDI-9033241 Peroxisomal protein import
R-DDI-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-DDI-917937 Iron uptake and transport
R-DDI-936440 Negative regulators of DDX58/IFIH1 signaling
R-DDI-937042 IRAK2 mediated activation of TAK1 complex
R-DDI-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-DDI-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CG78

Family and domain databases

InterProiView protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 7 hits
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 7 hits
SUPFAMiSSF54236 SSF54236, 7 hits
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 7 hits
PS50053 UBIQUITIN_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBIQF_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CG78
Secondary accession number(s): P08618
, Q54HH5, Q54L38, Q54SE1, Q54SP3, Q54UW7, Q54WJ3, Q550W7, Q55DZ5, Q86KQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 8, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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