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Entry version 81 (07 Apr 2021)
Sequence version 1 (10 Aug 2010)
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Protein

Polyubiquitin-A

Gene

ubq-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

By similarity

Miscellaneous

In C.elegans ubiquitin is encoded by 2 different genes. ubq-2 gene codes for a single copy of ubiquitin fused to the ribosomal proteins L40. ubq-1 gene codes for a polyubiquitin precursor with exact head to tail repeats.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-110320, Translesion Synthesis by POLH
R-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1253288, Downregulation of ERBB4 signaling
R-CEL-182971, EGFR downregulation
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-2173788, Downregulation of TGF-beta receptor signaling
R-CEL-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-CEL-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-2565942, Regulation of PLK1 Activity at G2/M Transition
R-CEL-2672351, Stimuli-sensing channels
R-CEL-3134975, Regulation of innate immune responses to cytosolic DNA
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4641258, Degradation of DVL
R-CEL-5205685, PINK1-PRKN Mediated Mitophagy
R-CEL-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-CEL-5358346, Hedgehog ligand biogenesis
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5675221, Negative regulation of MAPK pathway
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689877, Josephin domain DUBs
R-CEL-5689880, Ub-specific processing proteases
R-CEL-5689896, Ovarian tumor domain proteases
R-CEL-5689901, Metalloprotease DUBs
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5696394, DNA Damage Recognition in GG-NER
R-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-5696400, Dual Incision in GG-NER
R-CEL-6781823, Formation of TC-NER Pre-Incision Complex
R-CEL-6782135, Dual incision in TC-NER
R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6807004, Negative regulation of MET activity
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69231, Cyclin D associated events in G1
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828, Clathrin-mediated endocytosis
R-CEL-8863795, Downregulation of ERBB2 signaling
R-CEL-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-CEL-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948747, Regulation of PTEN localization
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-8951664, Neddylation
R-CEL-901032, ER Quality Control Compartment (ERQC)
R-CEL-9020702, Interleukin-1 signaling
R-CEL-9033241, Peroxisomal protein import
R-CEL-912631, Regulation of signaling by CBL
R-CEL-917729, Endosomal Sorting Complex Required For Transport (ESCRT)
R-CEL-917937, Iron uptake and transport
R-CEL-936440, Negative regulators of DDX58/IFIH1 signaling
R-CEL-9646399, Aggrephagy
R-CEL-9664873, Pexophagy
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyubiquitin-A
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ubq-1
Synonyms:ubia
ORF Names:F25B5.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F25B5.4 ; CE01921 ; WBGene00006727 ; ubq-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001148171 – 76UbiquitinAdd BLAST76
ChainiPRO_000039627077 – 152UbiquitinAdd BLAST76
ChainiPRO_0000396271153 – 228UbiquitinAdd BLAST76
ChainiPRO_0000396272229 – 304UbiquitinAdd BLAST76
ChainiPRO_0000396273305 – 380UbiquitinAdd BLAST76
ChainiPRO_0000396274381 – 456Ubiquitin-relatedAdd BLAST76
ChainiPRO_0000396275457 – 532UbiquitinAdd BLAST76
ChainiPRO_0000396276533 – 608UbiquitinAdd BLAST76
ChainiPRO_0000396277609 – 684UbiquitinAdd BLAST76
ChainiPRO_0000396278685 – 760UbiquitinAdd BLAST76
ChainiPRO_0000396279761 – 836UbiquitinAdd BLAST76
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000396280837 – 8382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0CG71

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CG71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006727, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0CG71, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41061, 20 interactors

Protein interaction database and analysis system

More...
IntActi
P0CG71, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F25B5.4a.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CG71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 76Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST76
Domaini77 – 152Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST76
Domaini153 – 228Ubiquitin-like 3PROSITE-ProRule annotationAdd BLAST76
Domaini229 – 304Ubiquitin-like 4PROSITE-ProRule annotationAdd BLAST76
Domaini305 – 380Ubiquitin-like 5PROSITE-ProRule annotationAdd BLAST76
Domaini381 – 456Ubiquitin-like 6PROSITE-ProRule annotationAdd BLAST76
Domaini457 – 532Ubiquitin-like 7PROSITE-ProRule annotationAdd BLAST76
Domaini533 – 608Ubiquitin-like 8PROSITE-ProRule annotationAdd BLAST76
Domaini609 – 684Ubiquitin-like 9PROSITE-ProRule annotationAdd BLAST76
Domaini685 – 760Ubiquitin-like 10PROSITE-ProRule annotationAdd BLAST76
Domaini761 – 836Ubiquitin-like 11PROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0001, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010412_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CG71

Identification of Orthologs from Complete Genome Data

More...
OMAi
HINTATF

Database of Orthologous Groups

More...
OrthoDBi
1536766at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CG71

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR019954, Ubiquitin_CS
IPR019956, Ubiquitin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00240, ubiquitin, 11 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00348, UBIQUITIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00213, UBQ, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236, SSF54236, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00299, UBIQUITIN_1, 11 hits
PS50053, UBIQUITIN_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQIFVKTLTG KTITLEVEAS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEASDTIE
110 120 130 140 150
NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR
160 170 180 190 200
GGMQIFVKTL TGKTITLEVE ASDTIENVKA KIQDKEGIPP DQQRLIFAGK
210 220 230 240 250
QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEASDT
260 270 280 290 300
IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
310 320 330 340 350
LRGGMQIFVK TLTGKTITLE VEASDTIENV KAKIQDKEGI PPDQQRLIFA
360 370 380 390 400
GKQLEDGRTL SDYNIQKEST LHLVLRLRGG MQIFVKTLIG KTITLEVEAS
410 420 430 440 450
DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV
460 470 480 490 500
LRLRGGMQIF VKTLTGKTIT LEVEASDTIE NVKAKIQDKE GIPPDQQRLI
510 520 530 540 550
FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE
560 570 580 590 600
ASDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH
610 620 630 640 650
LVLRLRGGMQ IFVKTLTGKT ITLEVEASDT IENVKAKIQD KEGIPPDQQR
660 670 680 690 700
LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGMQIFVK TLTGKTITLE
710 720 730 740 750
VEASDTIENV KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL SDYNIQKEST
760 770 780 790 800
LHLVLRLRGG MQIFVKTLTG KTITLEVEAS DTIENVKAKI QDKEGIPPDQ
810 820 830
QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGDI
Length:838
Mass (Da):93,987
Last modified:August 10, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CF0B1369DC312E6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23433 Genomic DNA Translation: AAA28154.1
FO081045 Genomic DNA Translation: CCD68779.1
M21321 Genomic DNA Translation: AAA28153.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A30126
T16144

NCBI Reference Sequences

More...
RefSeqi
NP_741157.1, NM_171139.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F25B5.4a.1; F25B5.4a.1; WBGene00006727
F25B5.4a.2; F25B5.4a.2; WBGene00006727

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F25B5.4

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23433 Genomic DNA Translation: AAA28154.1
FO081045 Genomic DNA Translation: CCD68779.1
M21321 Genomic DNA Translation: AAA28153.1
PIRiA30126
T16144
RefSeqiNP_741157.1, NM_171139.4

3D structure databases

SMRiP0CG71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41061, 20 interactors
IntActiP0CG71, 1 interactor
STRINGi6239.F25B5.4a.2

Proteomic databases

EPDiP0CG71
PaxDbiP0CG71

Genome annotation databases

EnsemblMetazoaiF25B5.4a.1; F25B5.4a.1; WBGene00006727
F25B5.4a.2; F25B5.4a.2; WBGene00006727
GeneIDi175840
KEGGicel:CELE_F25B5.4

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175840
WormBaseiF25B5.4 ; CE01921 ; WBGene00006727 ; ubq-1

Phylogenomic databases

eggNOGiKOG0001, Eukaryota
GeneTreeiENSGT00940000163900
HOGENOMiCLU_010412_1_0_1
InParanoidiP0CG71
OMAiHINTATF
OrthoDBi1536766at2759
PhylomeDBiP0CG71

Enzyme and pathway databases

ReactomeiR-CEL-110320, Translesion Synthesis by POLH
R-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1253288, Downregulation of ERBB4 signaling
R-CEL-182971, EGFR downregulation
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-2173788, Downregulation of TGF-beta receptor signaling
R-CEL-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-CEL-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-2565942, Regulation of PLK1 Activity at G2/M Transition
R-CEL-2672351, Stimuli-sensing channels
R-CEL-3134975, Regulation of innate immune responses to cytosolic DNA
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4641258, Degradation of DVL
R-CEL-5205685, PINK1-PRKN Mediated Mitophagy
R-CEL-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-CEL-5358346, Hedgehog ligand biogenesis
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5675221, Negative regulation of MAPK pathway
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689877, Josephin domain DUBs
R-CEL-5689880, Ub-specific processing proteases
R-CEL-5689896, Ovarian tumor domain proteases
R-CEL-5689901, Metalloprotease DUBs
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5696394, DNA Damage Recognition in GG-NER
R-CEL-5696395, Formation of Incision Complex in GG-NER
R-CEL-5696400, Dual Incision in GG-NER
R-CEL-6781823, Formation of TC-NER Pre-Incision Complex
R-CEL-6782135, Dual incision in TC-NER
R-CEL-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-6807004, Negative regulation of MET activity
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69231, Cyclin D associated events in G1
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8856825, Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828, Clathrin-mediated endocytosis
R-CEL-8863795, Downregulation of ERBB2 signaling
R-CEL-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-CEL-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948747, Regulation of PTEN localization
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-8951664, Neddylation
R-CEL-901032, ER Quality Control Compartment (ERQC)
R-CEL-9020702, Interleukin-1 signaling
R-CEL-9033241, Peroxisomal protein import
R-CEL-912631, Regulation of signaling by CBL
R-CEL-917729, Endosomal Sorting Complex Required For Transport (ESCRT)
R-CEL-917937, Iron uptake and transport
R-CEL-936440, Negative regulators of DDX58/IFIH1 signaling
R-CEL-9646399, Aggrephagy
R-CEL-9664873, Pexophagy
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

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PROi
PR:P0CG71

Gene expression databases

BgeeiWBGene00006727, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiP0CG71, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
IPR019954, Ubiquitin_CS
IPR019956, Ubiquitin_dom
PfamiView protein in Pfam
PF00240, ubiquitin, 11 hits
PRINTSiPR00348, UBIQUITIN
SMARTiView protein in SMART
SM00213, UBQ, 11 hits
SUPFAMiSSF54236, SSF54236, 11 hits
PROSITEiView protein in PROSITE
PS00299, UBIQUITIN_1, 11 hits
PS50053, UBIQUITIN_2, 11 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBIQ1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CG71
Secondary accession number(s): P14792, Q9U1P3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 7, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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