UniProtKB - P0CG50 (UBC_MOUSE)
Protein
Polyubiquitin-C
Gene
Ubc
Organism
Mus musculus (Mouse)
Status
Functioni
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.1 Publication
Miscellaneous
Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | Activating enzyme | 1 | |
Sitei | 68 | Essential for function | 1 | |
Binding sitei | 72 | Activating enzyme | 1 |
GO - Molecular functioni
- protease binding Source: MGI
- protein tag Source: GO_Central
- ubiquitin protein ligase binding Source: GO_Central
GO - Biological processi
- modification-dependent protein catabolic process Source: GO_Central
- protein ubiquitination Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-110312, Translesion synthesis by REV1 R-MMU-110314, Recognition of DNA damage by PCNA-containing replication complex R-MMU-110320, Translesion Synthesis by POLH R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-182971, EGFR downregulation R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-201681, TCF dependent signaling in response to WNT R-MMU-202424, Downstream TCR signaling R-MMU-205043, NRIF signals cell death from the nucleus R-MMU-209543, p75NTR recruits signalling complexes R-MMU-209560, NF-kB is activated and signals survival R-MMU-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-MMU-2173788, Downregulation of TGF-beta receptor signaling R-MMU-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559580, Oxidative Stress Induced Senescence R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585, Oncogene Induced Senescence R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2672351, Stimuli-sensing channels R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-382556, ABC-family proteins mediated transport R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-4641263, Regulation of FZD by ubiquitination R-MMU-5205685, PINK1-PRKN Mediated Mitophagy R-MMU-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5655862, Translesion synthesis by POLK R-MMU-5656121, Translesion synthesis by POLI R-MMU-5656169, Termination of translesion DNA synthesis R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675221, Negative regulation of MAPK pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-5685942, HDR through Homologous Recombination (HRR) R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689877, Josephin domain DUBs R-MMU-5689880, Ub-specific processing proteases R-MMU-5689896, Ovarian tumor domain proteases R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-5696395, Formation of Incision Complex in GG-NER R-MMU-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER R-MMU-5696400, Dual Incision in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-MMU-6783310, Fanconi Anemia Pathway R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6804757, Regulation of TP53 Degradation R-MMU-6804760, Regulation of TP53 Activity through Methylation R-MMU-6807004, Negative regulation of MET activity R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69231, Cyclin D associated events in G1 R-MMU-69481, G2/M Checkpoints R-MMU-69541, Stabilization of p53 R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948747, Regulation of PTEN localization R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-901032, ER Quality Control Compartment (ERQC) R-MMU-9010553, Regulation of expression of SLITs and ROBOs R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-MMU-9020702, Interleukin-1 signaling R-MMU-9033241, Peroxisomal protein import R-MMU-912631, Regulation of signaling by CBL R-MMU-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-MMU-917937, Iron uptake and transport R-MMU-936440, Negative regulators of DDX58/IFIH1 signaling R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937039, IRAK1 recruits IKK complex R-MMU-937041, IKK complex recruitment mediated by RIP1 R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-9646399, Aggrephagy R-MMU-9648002, RAS processing R-MMU-9664873, Pexophagy R-MMU-9706369, Negative regulation of FLT3 R-MMU-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Polyubiquitin-CCleaved into the following 3 chains: |
Gene namesi | Name:Ubc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98889, Ubc |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- myelin sheath Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000396192 | 1 – 76 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396193 | 77 – 152 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396194 | 153 – 228 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396195 | 229 – 304 | Ubiquitin-related 1Add BLAST | 76 | |
ChainiPRO_0000396196 | 305 – 380 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396197 | 381 – 456 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396198 | 457 – 532 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396199 | 533 – 608 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396200 | 609 – 684 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000396201 | 685 – 734 | Ubiquitin-related 2Add BLAST | 50 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 48 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 65 | Phosphoserine; by PINK1By similarity | 1 | |
Modified residuei | 76 | ADP-ribosylglycineBy similarity | 1 | |
Cross-linki | 76 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation | ||
Cross-linki | 82 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 87 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 103 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 105 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 124 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 141 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.By similarity
Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.By similarity
Keywords - PTMi
ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P0CG50 |
MaxQBi | P0CG50 |
PaxDbi | P0CG50 |
PRIDEi | P0CG50 |
ProteomicsDBi | 297694 |
2D gel databases
REPRODUCTION-2DPAGEi | P62991 |
PTM databases
iPTMneti | P0CG50 |
PhosphoSitePlusi | P0CG50 |
SwissPalmi | P0CG50 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000008348, Expressed in granulocyte and 317 other tissues |
Genevisiblei | P0CG50, MM |
Interactioni
GO - Molecular functioni
- protease binding Source: MGI
- ubiquitin protein ligase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 204403, 463 interactors |
IntActi | P0CG50, 2 interactors |
STRINGi | 10090.ENSMUSP00000115578 |
Miscellaneous databases
RNActi | P0CG50, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P0CG50 |
SMRi | P0CG50 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0CG50 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 77 – 152 | Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 153 – 228 | Ubiquitin-like 3PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 229 – 304 | Ubiquitin-like 4PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 305 – 380 | Ubiquitin-like 5PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 381 – 456 | Ubiquitin-like 6PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 457 – 532 | Ubiquitin-like 7PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 533 – 608 | Ubiquitin-like 8PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 609 – 684 | Ubiquitin-like 9PROSITE-ProRule annotationAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the ubiquitin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0001, Eukaryota |
GeneTreei | ENSGT00940000163900 |
HOGENOMi | CLU_010412_1_0_1 |
InParanoidi | P0CG50 |
OrthoDBi | 1536766at2759 |
TreeFami | TF354256 |
Family and domain databases
InterProi | View protein in InterPro IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS IPR019956, Ubiquitin_dom |
Pfami | View protein in Pfam PF00240, ubiquitin, 9 hits |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 9 hits |
SUPFAMi | SSF54236, SSF54236, 10 hits |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 9 hits PS50053, UBIQUITIN_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P0CG50-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE
110 120 130 140 150
NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR
160 170 180 190 200
GGMQIFVKTL TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK
210 220 230 240 250
QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT
260 270 280 290 300
IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
310 320 330 340 350
LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI PPDQQRLIFA
360 370 380 390 400
GKQLEDGRTL SDYNIQKEST LHLVLRLRGG MQIFVKTLTG KTITLEVEPS
410 420 430 440 450
DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV
460 470 480 490 500
LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI
510 520 530 540 550
FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE
560 570 580 590 600
PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH
610 620 630 640 650
LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD KEGIPPDQQR
660 670 680 690 700
LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGMQIFVK TLTGKTITLD
710 720 730
VEPSVTTKKV KQEDRRTFLT TVSKKSPPCA CSWV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q5F6 | E9Q5F6_MOUSE | Polyubiquitin-C | Ubc | 201 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | G → GGMQIFVKTLTGKTITLEVE PSDTIENVKAKIQDKEGIPP DQQRLIFAGKQLEDGRTLSD YNIQKESTLHLVLRLRGGMQ IFVKTLTGKTITLEVEPSDT IENVKAKIQDKEGIPPDQQR LIFAGKQLEGGRTLSDYNIQ KESTLHLVLRLRG in AAG00513 (PubMed:12107596).Curated | 1 | |
Sequence conflicti | 265 | P → S in AAG00512 (PubMed:12107596).Curated | 1 | |
Sequence conflicti | 265 | P → S in AAG00513 (PubMed:12107596).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285161 Genomic DNA Translation: AAG00512.1 AF285162 Genomic DNA Translation: AAG00513.1 AC138613 Genomic DNA No translation available. D50527 mRNA Translation: BAA09096.1 |
CCDSi | CCDS19684.2 |
PIRi | A49007 S11296 |
RefSeqi | NP_062613.3, NM_019639.4 |
Genome annotation databases
Ensembli | ENSMUST00000136312; ENSMUSP00000114180; ENSMUSG00000008348 ENSMUST00000156249; ENSMUSP00000115578; ENSMUSG00000008348 |
GeneIDi | 22190 |
KEGGi | mmu:22190 |
UCSCi | uc008zri.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285161 Genomic DNA Translation: AAG00512.1 AF285162 Genomic DNA Translation: AAG00513.1 AC138613 Genomic DNA No translation available. D50527 mRNA Translation: BAA09096.1 |
CCDSi | CCDS19684.2 |
PIRi | A49007 S11296 |
RefSeqi | NP_062613.3, NM_019639.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZNV | X-ray | 1.60 | B/C/E/F | 1-76 | [»] | |
3A1Q | X-ray | 2.20 | A/B/D/E | 1-76 | [»] | |
3A9J | X-ray | 1.18 | A/B | 1-76 | [»] | |
3A9K | X-ray | 1.40 | A/B | 1-76 | [»] | |
3VHT | X-ray | 2.40 | C | 1-76 | [»] | |
3WWQ | X-ray | 1.90 | A/B/D/E/G/H/J/K | 609-684 | [»] | |
3WXG | X-ray | 3.10 | B/E | 609-684 | [»] | |
C/F | 609-680 | [»] | ||||
4NQL | X-ray | 2.30 | B/C | 609-684 | [»] | |
6N5M | X-ray | 3.01 | A | 1-76 | [»] | |
BMRBi | P0CG50 | |||||
SMRi | P0CG50 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204403, 463 interactors |
IntActi | P0CG50, 2 interactors |
STRINGi | 10090.ENSMUSP00000115578 |
PTM databases
iPTMneti | P0CG50 |
PhosphoSitePlusi | P0CG50 |
SwissPalmi | P0CG50 |
2D gel databases
REPRODUCTION-2DPAGEi | P62991 |
Proteomic databases
jPOSTi | P0CG50 |
MaxQBi | P0CG50 |
PaxDbi | P0CG50 |
PRIDEi | P0CG50 |
ProteomicsDBi | 297694 |
Protocols and materials databases
Antibodypediai | 3954, 235 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000136312; ENSMUSP00000114180; ENSMUSG00000008348 ENSMUST00000156249; ENSMUSP00000115578; ENSMUSG00000008348 |
GeneIDi | 22190 |
KEGGi | mmu:22190 |
UCSCi | uc008zri.2, mouse |
Organism-specific databases
CTDi | 7316 |
MGIi | MGI:98889, Ubc |
Phylogenomic databases
eggNOGi | KOG0001, Eukaryota |
GeneTreei | ENSGT00940000163900 |
HOGENOMi | CLU_010412_1_0_1 |
InParanoidi | P0CG50 |
OrthoDBi | 1536766at2759 |
TreeFami | TF354256 |
Enzyme and pathway databases
Reactomei | R-MMU-110312, Translesion synthesis by REV1 R-MMU-110314, Recognition of DNA damage by PCNA-containing replication complex R-MMU-110320, Translesion Synthesis by POLH R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-182971, EGFR downregulation R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-201681, TCF dependent signaling in response to WNT R-MMU-202424, Downstream TCR signaling R-MMU-205043, NRIF signals cell death from the nucleus R-MMU-209543, p75NTR recruits signalling complexes R-MMU-209560, NF-kB is activated and signals survival R-MMU-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-MMU-2173788, Downregulation of TGF-beta receptor signaling R-MMU-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559580, Oxidative Stress Induced Senescence R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585, Oncogene Induced Senescence R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2672351, Stimuli-sensing channels R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-382556, ABC-family proteins mediated transport R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-4641263, Regulation of FZD by ubiquitination R-MMU-5205685, PINK1-PRKN Mediated Mitophagy R-MMU-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5655862, Translesion synthesis by POLK R-MMU-5656121, Translesion synthesis by POLI R-MMU-5656169, Termination of translesion DNA synthesis R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675221, Negative regulation of MAPK pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-5685942, HDR through Homologous Recombination (HRR) R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689877, Josephin domain DUBs R-MMU-5689880, Ub-specific processing proteases R-MMU-5689896, Ovarian tumor domain proteases R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-5696395, Formation of Incision Complex in GG-NER R-MMU-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER R-MMU-5696400, Dual Incision in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-MMU-6783310, Fanconi Anemia Pathway R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6804757, Regulation of TP53 Degradation R-MMU-6804760, Regulation of TP53 Activity through Methylation R-MMU-6807004, Negative regulation of MET activity R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69231, Cyclin D associated events in G1 R-MMU-69481, G2/M Checkpoints R-MMU-69541, Stabilization of p53 R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948747, Regulation of PTEN localization R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-901032, ER Quality Control Compartment (ERQC) R-MMU-9010553, Regulation of expression of SLITs and ROBOs R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-MMU-9020702, Interleukin-1 signaling R-MMU-9033241, Peroxisomal protein import R-MMU-912631, Regulation of signaling by CBL R-MMU-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-MMU-917937, Iron uptake and transport R-MMU-936440, Negative regulators of DDX58/IFIH1 signaling R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937039, IRAK1 recruits IKK complex R-MMU-937041, IKK complex recruitment mediated by RIP1 R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-9646399, Aggrephagy R-MMU-9648002, RAS processing R-MMU-9664873, Pexophagy R-MMU-9706369, Negative regulation of FLT3 R-MMU-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 22190, 5 hits in 52 CRISPR screens |
ChiTaRSi | Ubc, mouse |
EvolutionaryTracei | P0CG50 |
PROi | PR:P0CG50 |
RNActi | P0CG50, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000008348, Expressed in granulocyte and 317 other tissues |
Genevisiblei | P0CG50, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS IPR019956, Ubiquitin_dom |
Pfami | View protein in Pfam PF00240, ubiquitin, 9 hits |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 9 hits |
SUPFAMi | SSF54236, SSF54236, 10 hits |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 9 hits PS50053, UBIQUITIN_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBC_MOUSE | |
Accessioni | P0CG50Primary (citable) accession number: P0CG50 Secondary accession number(s): E9QKI0 Q9Z0H9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | July 27, 2011 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families