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Entry version 78 (16 Oct 2019)
Sequence version 1 (13 Jul 2010)
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Protein

POTE ankyrin domain family member J

Gene

POTEJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P0CG39

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POTE ankyrin domain family member J
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POTEJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:37094 POTEJ

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0CG39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000222038

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165697368

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P0CG39

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POTEJ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300681052

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003954141 – 1038POTE ankyrin domain family member JAdd BLAST1038

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0CG39

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0CG39

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P0CG39

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P0CG39

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CG39

PeptideAtlas

More...
PeptideAtlasi
P0CG39

PRoteomics IDEntifications database

More...
PRIDEi
P0CG39

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52469

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P0CG39

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CG39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0CG39

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P0CG39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000222038 Expressed in 13 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041264
HPA041271
HPA042822
HPA043260

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
576066, 11 interactors

Protein interaction database and analysis system

More...
IntActi
P0CG39, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CG39

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati135 – 164ANK 1Add BLAST30
Repeati168 – 197ANK 2Add BLAST30
Repeati201 – 230ANK 3Add BLAST30
Repeati234 – 263ANK 4Add BLAST30
Repeati267 – 296ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni666 – 1038Actin-likeAdd BLAST373

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili605 – 661Sequence analysisAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115614

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CG39

KEGG Orthology (KO)

More...
KOi
K17299

Database of Orthologous Groups

More...
OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CG39

TreeFam database of animal gene trees

More...
TreeFami
TF354237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00190 ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CG39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD
60 70 80 90 100
DSTMKTLRSK MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR
110 120 130 140 150
EDLDKLHRAA WWGKVARKDL IVMLRDTDVN KQDKQKRTAL HLASANGNSG
160 170 180 190 200
VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ EDECALMLLE HGTDPNIPDE
210 220 230 240 250
YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL LGVHEQKQQV
260 270 280 290 300
VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS
310 320 330 340 350
GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES
360 370 380 390 400
QRFKGSENSQ PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV
410 420 430 440 450
TAGNGDDGLI PQRKSRTPEN QQFPDNESEE YHRICELVSD YKEKQMPKYS
460 470 480 490 500
SENSNPEQDL KLTSEEESQR LKGSENGQPE KRSQEPEINK DGDRELENFM
510 520 530 540 550
AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT PESQQFPDTE
560 570 580 590 600
NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS
610 620 630 640 650
CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN
660 670 680 690 700
DNLLKALQLN ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC
710 720 730 740 750
PRQQGMMGGM HQKESYVGKE AQSKRGILTL KYPMEHGIIT NWDDMEKIWH
760 770 780 790 800
HTFYNELRVA PEEHPILLTE APLNPKANRE KMTQIMFETF NTPAMYVAIQ
810 820 830 840 850
AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR LDLAGRELTD
860 870 880 890 900
YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE
910 920 930 940 950
KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV
960 970 980 990 1000
DIRKDLYTNT VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY
1010 1020 1030
SVWVGGSILA SLSTFQQMWI SKQEYDESGP SIVHRKCF
Length:1,038
Mass (Da):117,390
Last modified:July 13, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFDFF97D149A0899
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC140481 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59432.1

NCBI Reference Sequences

More...
RefSeqi
NP_001264012.1, NM_001277083.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409602; ENSP00000387176; ENSG00000222038

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
653781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:653781

UCSC genome browser

More...
UCSCi
uc021vor.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140481 Genomic DNA No translation available.
CCDSiCCDS59432.1
RefSeqiNP_001264012.1, NM_001277083.1

3D structure databases

SMRiP0CG39
ModBaseiSearch...

Protein-protein interaction databases

BioGridi576066, 11 interactors
IntActiP0CG39, 3 interactors
STRINGi9606.ENSP00000387176

PTM databases

iPTMnetiP0CG39
PhosphoSitePlusiP0CG39
SwissPalmiP0CG39

Polymorphism and mutation databases

BioMutaiPOTEJ
DMDMi300681052

Proteomic databases

EPDiP0CG39
jPOSTiP0CG39
MassIVEiP0CG39
MaxQBiP0CG39
PaxDbiP0CG39
PeptideAtlasiP0CG39
PRIDEiP0CG39
ProteomicsDBi52469
TopDownProteomicsiP0CG39

Genome annotation databases

EnsembliENST00000409602; ENSP00000387176; ENSG00000222038
GeneIDi653781
KEGGihsa:653781
UCSCiuc021vor.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
653781

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POTEJ
HGNCiHGNC:37094 POTEJ
HPAiHPA041264
HPA041271
HPA042822
HPA043260
neXtProtiNX_P0CG39
OpenTargetsiENSG00000222038
PharmGKBiPA165697368

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITJG Eukaryota
KOG0676 Eukaryota
COG0666 LUCA
COG5277 LUCA
GeneTreeiENSGT00940000163068
HOGENOMiHOG000115614
InParanoidiP0CG39
KOiK17299
OrthoDBi649708at2759
PhylomeDBiP0CG39
TreeFamiTF354237

Enzyme and pathway databases

SignaLinkiP0CG39

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POTEJ human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
653781
PharosiP0CG39

Protein Ontology

More...
PROi
PR:P0CG39

Gene expression databases

BgeeiENSG00000222038 Expressed in 13 organ(s), highest expression level in testis

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOTEJ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CG39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 16, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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