Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cryptic family protein 1B

Gene

CFC1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism.Curated

GO - Molecular functioni

  • activin receptor binding Source: GO_Central
  • nodal binding Source: GO_Central
  • signaling receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processGastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic family protein 1B
Gene namesi
Name:CFC1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152093.7
HGNCiHGNC:33983 CFC1B
neXtProtiNX_P0CG36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi653275
OpenTargetsiENSG00000152093
PharmGKBiPA162382207

Polymorphism and mutation databases

BioMutaiCFC1B
DMDMi300680885

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000039540826 – 223Cryptic family protein 1BAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 97PROSITE-ProRule annotation
Disulfide bondi91 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0CG36
PRIDEiP0CG36
ProteomicsDBi52466

Expressioni

Gene expression databases

BgeeiENSG00000152093 Expressed in 21 organ(s), highest expression level in substantia nigra
ExpressionAtlasiP0CG36 baseline
GenevisibleiP0CG36 HS

Organism-specific databases

HPAiHPA041773

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281882

Structurei

3D structure databases

ProteinModelPortaliP0CG36
SMRiP0CG36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 115EGF-likePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00530000063804
HOGENOMiHOG000090236
InParanoidiP0CG36
OMAiPYSWAFG
OrthoDBiEOG091G0REL
PhylomeDBiP0CG36
TreeFamiTF333187

Family and domain databases

InterProiView protein in InterPro
IPR019011 Cryptic/Cripto_CFC-dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PfamiView protein in Pfam
PF09443 CFC, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P0CG36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP
60 70 80 90 100
LNWTSSHFGE VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG
110 120 130 140 150
SFCVCPAHFT GRYCEHDQRR SECGALEHGA WTLRACHLCR CIFGALHCLP
160 170 180 190 200
LQTPDRCDPK DFLASHAHGP SAGGAPSLLL LLPCALLHRL LRPDAPAHPR
210 220
SLVPSVLQRE RRPCGRPGLG HRL
Length:223
Mass (Da):24,642
Last modified:July 13, 2010 - v1
Checksum:i457EB443BC0CF1A5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0G3A0A087X0G3_HUMAN
Cryptic family protein 1B
CFC1B
191Annotation score:
A0A087WWE4A0A087WWE4_HUMAN
Cryptic family protein 1B
CFC1B
148Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA Translation: AAY14955.1
CCDSiCCDS33286.1
RefSeqiNP_001072998.1, NM_001079530.1
UniGeneiHs.503733

Genome annotation databases

EnsembliENST00000281882; ENSP00000281882; ENSG00000152093
GeneIDi653275
KEGGihsa:653275
UCSCiuc002trl.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA Translation: AAY14955.1
CCDSiCCDS33286.1
RefSeqiNP_001072998.1, NM_001079530.1
UniGeneiHs.503733

3D structure databases

ProteinModelPortaliP0CG36
SMRiP0CG36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281882

Polymorphism and mutation databases

BioMutaiCFC1B
DMDMi300680885

Proteomic databases

PaxDbiP0CG36
PRIDEiP0CG36
ProteomicsDBi52466

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281882; ENSP00000281882; ENSG00000152093
GeneIDi653275
KEGGihsa:653275
UCSCiuc002trl.3 human

Organism-specific databases

CTDi653275
DisGeNETi653275
EuPathDBiHostDB:ENSG00000152093.7
GeneCardsiCFC1B
HGNCiHGNC:33983 CFC1B
HPAiHPA041773
neXtProtiNX_P0CG36
OpenTargetsiENSG00000152093
PharmGKBiPA162382207
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00530000063804
HOGENOMiHOG000090236
InParanoidiP0CG36
OMAiPYSWAFG
OrthoDBiEOG091G0REL
PhylomeDBiP0CG36
TreeFamiTF333187

Miscellaneous databases

ChiTaRSiCFC1B human
GeneWikiiCripto
GenomeRNAii653275
PROiPR:P0CG36

Gene expression databases

BgeeiENSG00000152093 Expressed in 21 organ(s), highest expression level in substantia nigra
ExpressionAtlasiP0CG36 baseline
GenevisibleiP0CG36 HS

Family and domain databases

InterProiView protein in InterPro
IPR019011 Cryptic/Cripto_CFC-dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PfamiView protein in Pfam
PF09443 CFC, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFC1B_HUMAN
AccessioniPrimary (citable) accession number: P0CG36
Secondary accession number(s): B2RCY0
, B9EJD3, Q53T05, Q9GZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again