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Protein

Thymosin beta-15B

Gene

TMSB15B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.By similarity1 Publication

GO - Molecular functioni

  • actin monomer binding Source: GO_Central
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB

GO - Biological processi

  • actin filament organization Source: InterPro
  • positive regulation of cell migration Source: UniProtKB
  • regulation of cell migration Source: GO_Central
  • sequestering of actin monomers Source: GO_Central

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-15B
Gene namesi
Name:TMSB15B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000158427.14
HGNCiHGNC:28612 TMSB15B
MIMi301011 gene
neXtProtiNX_P0CG35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi11013
286527
OpenTargetsiENSG00000158164
ENSG00000158427
ENSG00000269226
PharmGKBiPA164726584

Polymorphism and mutation databases

DMDMi300681172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003954012 – 45Thymosin beta-15BAdd BLAST44

Proteomic databases

EPDiP0CG35
MaxQBiP0CG35
PRIDEiP0CG35
ProteomicsDBi52465

PTM databases

iPTMnetiP0CG35
PhosphoSitePlusiP0CG35

Expressioni

Tissue specificityi

Expressed in colon and colon cancer tissue.1 Publication

Gene expression databases

BgeeiENSG00000158427 Expressed in 89 organ(s), highest expression level in heart
ExpressionAtlasiP0CG35 baseline and differential
GenevisibleiP0CG35 HS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP0CG35
SMRiP0CG35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
InParanoidiP0CG35
PhylomeDBiP0CG35

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0CG35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MSDKPDLSEV EKFDRSKLKK TNTEEKNTLP SKETIQQEKE CVQTS
Length:45
Mass (Da):5,229
Last modified:July 13, 2010 - v1
Checksum:iB1182868530D59C2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BU88H3BU88_HUMAN
Thymosin beta-15B
TMSB15B
45Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291479 mRNA Translation: BAF84168.1
AK311771 mRNA Translation: BAG34714.1
Z70227 Genomic DNA No translation available.
CCDSiCCDS59172.1
RefSeqiNP_068832.1, NM_021992.2
NP_919305.2, NM_194324.2
UniGeneiHs.56145
Hs.675540
Hs.709594

Genome annotation databases

EnsembliENST00000419165; ENSP00000456121; ENSG00000158427
ENST00000436583; ENSP00000455771; ENSG00000158427
ENST00000540220; ENSP00000455371; ENSG00000158427
ENST00000569577; ENSP00000457057; ENSG00000158427
GeneIDi11013
286527
KEGGihsa:11013
hsa:286527
UCSCiuc004eje.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291479 mRNA Translation: BAF84168.1
AK311771 mRNA Translation: BAG34714.1
Z70227 Genomic DNA No translation available.
CCDSiCCDS59172.1
RefSeqiNP_068832.1, NM_021992.2
NP_919305.2, NM_194324.2
UniGeneiHs.56145
Hs.675540
Hs.709594

3D structure databases

ProteinModelPortaliP0CG35
SMRiP0CG35
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0CG35
PhosphoSitePlusiP0CG35

Polymorphism and mutation databases

DMDMi300681172

Proteomic databases

EPDiP0CG35
MaxQBiP0CG35
PRIDEiP0CG35
ProteomicsDBi52465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419165; ENSP00000456121; ENSG00000158427
ENST00000436583; ENSP00000455771; ENSG00000158427
ENST00000540220; ENSP00000455371; ENSG00000158427
ENST00000569577; ENSP00000457057; ENSG00000158427
GeneIDi11013
286527
KEGGihsa:11013
hsa:286527
UCSCiuc004eje.4 human

Organism-specific databases

CTDi11013
286527
DisGeNETi11013
286527
EuPathDBiHostDB:ENSG00000158427.14
GeneCardsiTMSB15B
HGNCiHGNC:28612 TMSB15B
MIMi301011 gene
neXtProtiNX_P0CG35
OpenTargetsiENSG00000158164
ENSG00000158427
ENSG00000269226
PharmGKBiPA164726584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
InParanoidiP0CG35
PhylomeDBiP0CG35

Miscellaneous databases

PROiPR:P0CG35
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158427 Expressed in 89 organ(s), highest expression level in heart
ExpressionAtlasiP0CG35 baseline and differential
GenevisibleiP0CG35 HS

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTB15B_HUMAN
AccessioniPrimary (citable) accession number: P0CG35
Secondary accession number(s): A8K614, Q99406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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