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Protein

Thymosin beta-15A

Gene

TMSB15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-15A
Alternative name(s):
NB thymosin beta
Thymosin-like protein 8
Gene namesi
Name:TMSB15A
Synonyms:TMSL8, TMSNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000158164.6
HGNCiHGNC:30744 TMSB15A
MIMi300939 gene
neXtProtiNX_P0CG34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi11013
286527
OpenTargetsiENSG00000158164
ENSG00000158427
ENSG00000269226
PharmGKBiPA164726584

Polymorphism and mutation databases

BioMutaiTMSB15A
DMDMi300681171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001851592 – 45Thymosin beta-15AAdd BLAST44

Proteomic databases

EPDiP0CG34
PaxDbiP0CG34
PeptideAtlasiP0CG34
PRIDEiP0CG34
ProteomicsDBi52464

PTM databases

iPTMnetiP0CG34
PhosphoSitePlusiP0CG34

Expressioni

Tissue specificityi

Neuroblastoma-specific.1 Publication

Inductioni

Down-regulated by TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000158164 Expressed in 133 organ(s), highest expression level in cerebral cortex
GenevisibleiP0CG34 HS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP0CG34
SMRiP0CG34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
InParanoidiP0CG34
PhylomeDBiP0CG34

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MSDKPDLSEV EKFDRSKLKK TNTEEKNTLP SKETIQQEKE CVQTS
Length:45
Mass (Da):5,229
Last modified:July 13, 2010 - v1
Checksum:iB1182868530D59C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82345 mRNA Translation: BAA11556.1
AL035609 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54739.1
BC000183 mRNA Translation: AAH00183.1
CCDSiCCDS14498.1
PIRiJC5274
RefSeqiNP_068832.1, NM_021992.2
NP_919305.2, NM_194324.2
UniGeneiHs.56145
Hs.675540
Hs.709594

Genome annotation databases

EnsembliENST00000289373; ENSP00000289373; ENSG00000158164
GeneIDi11013
286527
KEGGihsa:11013
hsa:286527

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82345 mRNA Translation: BAA11556.1
AL035609 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54739.1
BC000183 mRNA Translation: AAH00183.1
CCDSiCCDS14498.1
PIRiJC5274
RefSeqiNP_068832.1, NM_021992.2
NP_919305.2, NM_194324.2
UniGeneiHs.56145
Hs.675540
Hs.709594

3D structure databases

ProteinModelPortaliP0CG34
SMRiP0CG34
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0CG34
PhosphoSitePlusiP0CG34

Polymorphism and mutation databases

BioMutaiTMSB15A
DMDMi300681171

Proteomic databases

EPDiP0CG34
PaxDbiP0CG34
PeptideAtlasiP0CG34
PRIDEiP0CG34
ProteomicsDBi52464

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289373; ENSP00000289373; ENSG00000158164
GeneIDi11013
286527
KEGGihsa:11013
hsa:286527

Organism-specific databases

CTDi11013
286527
DisGeNETi11013
286527
EuPathDBiHostDB:ENSG00000158164.6
GeneCardsiTMSB15A
HGNCiHGNC:30744 TMSB15A
MIMi300939 gene
neXtProtiNX_P0CG34
OpenTargetsiENSG00000158164
ENSG00000158427
ENSG00000269226
PharmGKBiPA164726584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
InParanoidiP0CG34
PhylomeDBiP0CG34

Miscellaneous databases

GeneWikiiTMSB15A
TMSB15B
PROiPR:P0CG34
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158164 Expressed in 133 organ(s), highest expression level in cerebral cortex
GenevisibleiP0CG34 HS

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTB15A_HUMAN
AccessioniPrimary (citable) accession number: P0CG34
Secondary accession number(s): A8K614, Q99406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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