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Protein

Putative zinc finger protein 286B

Gene

ZNF286B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Caution

Could be the product of a pseudogene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 266C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 286B
Gene namesi
Name:ZNF286B
Synonyms:ZNF286C, ZNF286L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000249459.8
HGNCiHGNC:33241 ZNF286B
neXtProtiNX_P0CG31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410081

Polymorphism and mutation databases

BioMutaiZNF286B
DMDMi300681206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953601 – 522Putative zinc finger protein 286BAdd BLAST522

Proteomic databases

EPDiP0CG31
MaxQBiP0CG31
PaxDbiP0CG31
PeptideAtlasiP0CG31
PRIDEiP0CG31
ProteomicsDBi52461

PTM databases

iPTMnetiP0CG31
PhosphoSitePlusiP0CG31

Expressioni

Gene expression databases

BgeeiENSG00000249459 Expressed in 89 organ(s), highest expression level in cerebellum
ExpressionAtlasiP0CG31 baseline and differential
GenevisibleiP0CG31 HS

Organism-specific databases

HPAiHPA068125

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000461413

Structurei

3D structure databases

ProteinModelPortaliP0CG31
SMRiP0CG31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 266C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
InParanoidiP0CG31
KOiK09228
OMAiNICAESI
OrthoDBiEOG091G02KC
PhylomeDBiP0CG31
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P0CG31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP
60 70 80 90 100
GSRSLRGVHV PPPLHPAPAR EEIKSTCSLK ACFSLSLTLT YYRTAFLLST
110 120 130 140 150
ENEGNLHFQC PSDVETRPQS KDSTSVQDFS KAESCKVAII DRLTRNSVYD
160 170 180 190 200
SNLEAALECE NWLEKQQGNQ ERHLREMFTH MNSLSEETDH EHDVYWKSFN
210 220 230 240 250
QKSVLITEDR VPKGSYAFHT LEKSLKQKSN LMKKQRTYKE KKPHKCNDCG
260 270 280 290 300
ELFTCHSVHI QHQRVHTGEK PYTCNECGKS FSHRANLTKH QRTHTRILFE
310 320 330 340 350
CRECKKTFTE SSSLATHQRI HVGERPYECN ECGKGFNRST HLVQHQLIHT
360 370 380 390 400
GVRPYECNEC DKAFIHSSAL IKHQRTHTGE KPYKCQECGK AFSHCSSLTK
410 420 430 440 450
HQRVHTGEKP YECSECGKTF SQSTHLVQHQ RIHTGEKPYE CSECGKTFSQ
460 470 480 490 500
SSNFAKHQRI HIGKKPYKCS ECGKAFIHSS ALIQHQRTHT GEKPFRCNEC
510 520
GKSFKCSSSL IRHQRVHTEE QP
Length:522
Mass (Da):59,572
Last modified:July 13, 2010 - v1
Checksum:iD1818B9F64EE43D1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L365I3L365_HUMAN
Putative zinc finger protein 286B
ZNF286B
65Annotation score:
J3QKZ1J3QKZ1_HUMAN
Putative zinc finger protein 286B
ZNF286B
106Annotation score:
J3KS91J3KS91_HUMAN
Putative zinc finger protein 286B
ZNF286B
129Annotation score:
I3L3U3I3L3U3_HUMAN
Putative zinc finger protein 286B
ZNF286B
112Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026271 Genomic DNA No translation available.
CCDSiCCDS58523.1
RefSeqiNP_001138517.1, NM_001145045.1
UniGeneiHs.534279

Genome annotation databases

EnsembliENST00000545289; ENSP00000461413; ENSG00000249459
GeneIDi729288
KEGGihsa:729288
UCSCiuc010vyd.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026271 Genomic DNA No translation available.
CCDSiCCDS58523.1
RefSeqiNP_001138517.1, NM_001145045.1
UniGeneiHs.534279

3D structure databases

ProteinModelPortaliP0CG31
SMRiP0CG31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000461413

PTM databases

iPTMnetiP0CG31
PhosphoSitePlusiP0CG31

Polymorphism and mutation databases

BioMutaiZNF286B
DMDMi300681206

Proteomic databases

EPDiP0CG31
MaxQBiP0CG31
PaxDbiP0CG31
PeptideAtlasiP0CG31
PRIDEiP0CG31
ProteomicsDBi52461

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545289; ENSP00000461413; ENSG00000249459
GeneIDi729288
KEGGihsa:729288
UCSCiuc010vyd.3 human

Organism-specific databases

CTDi729288
EuPathDBiHostDB:ENSG00000249459.8
GeneCardsiZNF286B
HGNCiHGNC:33241 ZNF286B
HPAiHPA068125
neXtProtiNX_P0CG31
PharmGKBiPA162410081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
InParanoidiP0CG31
KOiK09228
OMAiNICAESI
OrthoDBiEOG091G02KC
PhylomeDBiP0CG31
TreeFamiTF337055

Miscellaneous databases

ChiTaRSiZNF286B human
GenomeRNAii729288

Gene expression databases

BgeeiENSG00000249459 Expressed in 89 organ(s), highest expression level in cerebellum
ExpressionAtlasiP0CG31 baseline and differential
GenevisibleiP0CG31 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ286B_HUMAN
AccessioniPrimary (citable) accession number: P0CG31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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