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UniProtKB - P0CG30 (GSTT2_HUMAN)
Protein
Glutathione S-transferase theta-2B
Gene
GSTT2B
Organism
Homo sapiens (Human)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Catalytic activityi
- EC:2.5.1.18
GO - Molecular functioni
- glutathione transferase activity Source: GO_Central
GO - Biological processi
- glutathione metabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P0CG30 |
Reactomei | R-HSA-156590, Glutathione conjugation |
SignaLinki | P0CG30 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase theta-2B (EC:2.5.1.18)Alternative name(s): GST class-theta-2 Glutathione S-transferase theta-2 |
Gene namesi | Name:GSTT2B Synonyms:GSTT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33437, GSTT2B |
neXtProti | NX_P0CG30 |
VEuPathDBi | HostDB:ENSG00000133433 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 653689 |
OpenTargetsi | ENSG00000133433 |
PharmGKBi | PA162390358 |
Miscellaneous databases
Pharosi | P0CG30, Tbio |
Chemistry databases
DrugBanki | DB03310, Glutathione disulfide |
Genetic variation databases
BioMutai | GSTT2B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000395344 | 2 – 244 | Glutathione S-transferase theta-2BAdd BLAST | 243 |
Proteomic databases
EPDi | P0CG30 |
jPOSTi | P0CG30 |
MassIVEi | P0CG30 |
MaxQBi | P0CG30 |
PaxDbi | P0CG30 |
PeptideAtlasi | P0CG30 |
PRIDEi | P0CG30 |
PTM databases
GlyGeni | P0CG30, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P0CG30 |
PhosphoSitePlusi | P0CG30 |
Expressioni
Tissue specificityi
Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.1 Publication
Gene expression databases
Bgeei | ENSG00000133433, Expressed in adrenal tissue and 111 other tissues |
ExpressionAtlasi | P0CG30, baseline and differential |
Genevisiblei | P0CG30, HS |
Organism-specific databases
HPAi | ENSG00000133433, Group enriched (adrenal gland, breast) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 109208, 3 interactors 575985, 6 interactors |
IntActi | P0CG30, 4 interactors |
STRINGi | 9606.ENSP00000290765 |
Miscellaneous databases
RNActi | P0CG30, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0CG30 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0CG30 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 82 | GST N-terminalAdd BLAST | 81 | |
Domaini | 88 – 224 | GST C-terminalAdd BLAST | 137 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 41 | Glutathione binding | 2 | |
Regioni | 53 – 54 | Glutathione binding | 2 | |
Regioni | 66 – 67 | Glutathione binding | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota |
GeneTreei | ENSGT00940000162786 |
HOGENOMi | CLU_011226_2_0_1 |
InParanoidi | P0CG30 |
OMAi | AYKVRLF |
OrthoDBi | 1231780at2759 |
PhylomeDBi | P0CG30 |
TreeFami | TF325759 |
Family and domain databases
CDDi | cd03183, GST_C_Theta, 1 hit cd03050, GST_N_Theta, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR040077, GST_C_Theta IPR040075, GST_N_Theta IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P0CG30-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS
60 70 80 90 100
LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG
110 120 130 140 150
WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF
160 170 180 190 200
LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF
210 220 230 240
LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6ICJ4 | Q6ICJ4_HUMAN | Glutathione transferase | GSTT2B Em:AP000351.3, GSTT2, hCG_41095 | 230 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | G → V AA sequence (PubMed:1417752).Curated | 1 | |
Sequence conflicti | 156 – 158 | FLA → P in AAC13317 (Ref. 2) Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033982 | 139 | M → I1 PublicationCorresponds to variant dbSNP:rs1622002Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38503 mRNA Translation: AAB63956.1 AF057176 , AF057173, AF057174, AF057175 Genomic DNA Translation: AAC13317.1 CR456500 mRNA Translation: CAG30386.1 AP000350 Genomic DNA No translation available. BC002415 mRNA Translation: AAH02415.1 |
CCDSi | CCDS33617.1 |
PIRi | A56847 |
RefSeqi | NP_001074312.1, NM_001080843.3 |
Genome annotation databases
Ensembli | ENST00000290765; ENSP00000290765; ENSG00000133433 ENST00000616938; ENSP00000478389; ENSG00000278695 |
GeneIDi | 653689 |
KEGGi | hsa:653689 |
MANE-Selecti | ENST00000290765.9; ENSP00000290765.4; NM_001080843.4; NP_001074312.1 |
UCSCi | uc002zyw.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38503 mRNA Translation: AAB63956.1 AF057176 , AF057173, AF057174, AF057175 Genomic DNA Translation: AAC13317.1 CR456500 mRNA Translation: CAG30386.1 AP000350 Genomic DNA No translation available. BC002415 mRNA Translation: AAH02415.1 |
CCDSi | CCDS33617.1 |
PIRi | A56847 |
RefSeqi | NP_001074312.1, NM_001080843.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LJR | X-ray | 3.20 | A/B | 1-244 | [»] | |
2LJR | X-ray | 3.20 | A/B | 1-244 | [»] | |
3LJR | X-ray | 3.30 | A/B | 1-244 | [»] | |
4MPG | X-ray | 1.95 | A/B | 1-244 | [»] | |
SMRi | P0CG30 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109208, 3 interactors 575985, 6 interactors |
IntActi | P0CG30, 4 interactors |
STRINGi | 9606.ENSP00000290765 |
Chemistry databases
DrugBanki | DB03310, Glutathione disulfide |
PTM databases
GlyGeni | P0CG30, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P0CG30 |
PhosphoSitePlusi | P0CG30 |
Genetic variation databases
BioMutai | GSTT2B |
Proteomic databases
EPDi | P0CG30 |
jPOSTi | P0CG30 |
MassIVEi | P0CG30 |
MaxQBi | P0CG30 |
PaxDbi | P0CG30 |
PeptideAtlasi | P0CG30 |
PRIDEi | P0CG30 |
Protocols and materials databases
Antibodypediai | 23874, 66 antibodies from 20 providers |
DNASUi | 2953 |
Genome annotation databases
Ensembli | ENST00000290765; ENSP00000290765; ENSG00000133433 ENST00000616938; ENSP00000478389; ENSG00000278695 |
GeneIDi | 653689 |
KEGGi | hsa:653689 |
MANE-Selecti | ENST00000290765.9; ENSP00000290765.4; NM_001080843.4; NP_001074312.1 |
UCSCi | uc002zyw.5, human |
Organism-specific databases
CTDi | 653689 |
DisGeNETi | 653689 |
GeneCardsi | GSTT2B |
HGNCi | HGNC:33437, GSTT2B |
HPAi | ENSG00000133433, Group enriched (adrenal gland, breast) |
neXtProti | NX_P0CG30 |
OpenTargetsi | ENSG00000133433 |
PharmGKBi | PA162390358 |
VEuPathDBi | HostDB:ENSG00000133433 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota |
GeneTreei | ENSGT00940000162786 |
HOGENOMi | CLU_011226_2_0_1 |
InParanoidi | P0CG30 |
OMAi | AYKVRLF |
OrthoDBi | 1231780at2759 |
PhylomeDBi | P0CG30 |
TreeFami | TF325759 |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 2681 |
PathwayCommonsi | P0CG30 |
Reactomei | R-HSA-156590, Glutathione conjugation |
SignaLinki | P0CG30 |
Miscellaneous databases
BioGRID-ORCSi | 653689, 288 hits in 954 CRISPR screens |
EvolutionaryTracei | P0CG30 |
GeneWikii | GSTT2 |
GenomeRNAii | 653689 |
Pharosi | P0CG30, Tbio |
PROi | PR:P0CG30 |
RNActi | P0CG30, protein |
Gene expression databases
Bgeei | ENSG00000133433, Expressed in adrenal tissue and 111 other tissues |
ExpressionAtlasi | P0CG30, baseline and differential |
Genevisiblei | P0CG30, HS |
Family and domain databases
CDDi | cd03183, GST_C_Theta, 1 hit cd03050, GST_N_Theta, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR040077, GST_C_Theta IPR040075, GST_N_Theta IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTT2_HUMAN | |
Accessioni | P0CG30Primary (citable) accession number: P0CG30 Secondary accession number(s): O60665 Q9HD76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 13, 2010 |
Last sequence update: | July 13, 2010 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families