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Protein

Glutathione S-transferase theta-2B

Gene

GSTT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2B (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Glutathione S-transferase theta-2
Gene namesi
Name:GSTT2B
Synonyms:GSTT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000133433.10
HGNCiHGNC:33437 GSTT2B
neXtProtiNX_P0CG30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi653689
OpenTargetsiENSG00000133433
PharmGKBiPA162390358

Polymorphism and mutation databases

BioMutaiGSTT2B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003953442 – 244Glutathione S-transferase theta-2BAdd BLAST243

Proteomic databases

EPDiP0CG30
MaxQBiP0CG30
PaxDbiP0CG30
PeptideAtlasiP0CG30
PRIDEiP0CG30
ProteomicsDBi52460

PTM databases

iPTMnetiP0CG30
PhosphoSitePlusiP0CG30

Expressioni

Tissue specificityi

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.1 Publication

Gene expression databases

BgeeiENSG00000133433
ExpressionAtlasiP0CG30 baseline and differential
GenevisibleiP0CG30 HS

Organism-specific databases

HPAiHPA000750

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109208, 2 interactors
575985, 5 interactors
IntActiP0CG30, 1 interactor
STRINGi9606.ENSP00000290765

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 23Combined sources12
Beta strandi28 – 32Combined sources5
Turni35 – 38Combined sources4
Helixi39 – 41Combined sources3
Helixi43 – 46Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi62 – 65Combined sources4
Helixi67 – 77Combined sources11
Helixi82 – 84Combined sources3
Helixi89 – 105Combined sources17
Turni106 – 111Combined sources6
Helixi112 – 117Combined sources6
Helixi119 – 122Combined sources4
Helixi129 – 148Combined sources20
Turni149 – 153Combined sources5
Beta strandi154 – 156Combined sources3
Beta strandi159 – 161Combined sources3
Helixi164 – 178Combined sources15
Turni183 – 186Combined sources4
Helixi188 – 201Combined sources14
Helixi203 – 222Combined sources20
Helixi230 – 241Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJRX-ray3.20A/B1-244[»]
2LJRX-ray3.20A/B1-244[»]
3LJRX-ray3.30A/B1-244[»]
4MPGX-ray1.95A/B1-244[»]
ProteinModelPortaliP0CG30
SMRiP0CG30
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CG30

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 224GST C-terminalAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Glutathione binding2
Regioni53 – 54Glutathione binding2
Regioni66 – 67Glutathione binding2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
InParanoidiP0CG30
KOiK00799
OMAiVEEYLSW
OrthoDBiEOG091G0PCG
PhylomeDBiP0CG30
TreeFamiTF325759

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS
60 70 80 90 100
LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG
110 120 130 140 150
WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF
160 170 180 190 200
LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF
210 220 230 240
LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
Length:244
Mass (Da):27,507
Last modified:July 13, 2010 - v1
Checksum:iDBAF5D00F8C2FFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2G → V AA sequence (PubMed:1417752).Curated1
Sequence conflicti156 – 158FLA → P in AAC13317 (Ref. 2) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033982139M → I1 PublicationCorresponds to variant dbSNP:rs1622002Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38503 mRNA Translation: AAB63956.1
AF057176
, AF057173, AF057174, AF057175 Genomic DNA Translation: AAC13317.1
CR456500 mRNA Translation: CAG30386.1
AP000350 Genomic DNA No translation available.
BC002415 mRNA Translation: AAH02415.1
CCDSiCCDS33617.1
PIRiA56847
RefSeqiNP_001074312.1, NM_001080843.3
UniGeneiHs.654462
Hs.656498

Genome annotation databases

EnsembliENST00000290765; ENSP00000290765; ENSG00000133433
ENST00000616938; ENSP00000478389; ENSG00000278695
GeneIDi653689
KEGGihsa:653689
UCSCiuc002zyw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGSTT2_HUMAN
AccessioniPrimary (citable) accession number: P0CG30
Secondary accession number(s): O60665
, P30712, Q6IPV7, Q9HD76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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