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Protein

Glutathione S-transferase theta-2

Gene

GSTT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Gene namesi
Name:GSTT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4642 GSTT2
MIMi600437 gene
neXtProtiNX_P0CG29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2953

Chemistry databases

ChEMBLiCHEMBL2142
DrugBankiDB04132 S-Hexylglutathione

Polymorphism and mutation databases

DMDMi300680960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001859392 – 244Glutathione S-transferase theta-2Add BLAST243

Proteomic databases

MaxQBiP0CG29
PaxDbiP0CG29
PeptideAtlasiP0CG29
PRIDEiP0CG29
ProteomicsDBi52459

PTM databases

iPTMnetiP0CG29
PhosphoSitePlusiP0CG29

Expressioni

Tissue specificityi

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.1 Publication

Organism-specific databases

HPAiHPA000750

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9606.ENSP00000215780

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP0CG29
SMRiP0CG29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 224GST C-terminalAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000125747
InParanoidiP0CG29
KOiK00799
OrthoDBiEOG091G0PCG
PhylomeDBiP0CG29
TreeFamiTF325759

Family and domain databases

CDDicd03183 GST_C_Theta, 1 hit
cd03050 GST_N_Theta, 1 hit
InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR040077 GST_C_Theta
IPR040075 GST_N_Theta
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0CG29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS
60 70 80 90 100
LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG
110 120 130 140 150
WHADCIRGTF GIPLWVQVLG PLIGVQVPKE KVERNRTAMD QALQWLEDKF
160 170 180 190 200
LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF
210 220 230 240
LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
Length:244
Mass (Da):27,506
Last modified:July 13, 2010 - v1
Checksum:iDBA15D045262FFC3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY67A0A087WY67_HUMAN
Glutathione S-transferase theta-2
GSTT2
243Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2G → V AA sequence (PubMed:1417752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240786 Genomic DNA Translation: AAG02373.1
AP000351 Genomic DNA No translation available.
PIRiA56847
RefSeqiNP_000845.2, NM_000854.4
UniGeneiHs.654462
Hs.656498

Genome annotation databases

EnsembliENST00000215780; ENSP00000215780; ENSG00000099984
ENST00000618279; ENSP00000477540; ENSG00000277897
GeneIDi2953
KEGGihsa:2953
UCSCiuc032qyg.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240786 Genomic DNA Translation: AAG02373.1
AP000351 Genomic DNA No translation available.
PIRiA56847
RefSeqiNP_000845.2, NM_000854.4
UniGeneiHs.654462
Hs.656498

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MPFX-ray2.10A/B1-244[»]
ProteinModelPortaliP0CG29
SMRiP0CG29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000215780

Chemistry databases

ChEMBLiCHEMBL2142
DrugBankiDB04132 S-Hexylglutathione

PTM databases

iPTMnetiP0CG29
PhosphoSitePlusiP0CG29

Polymorphism and mutation databases

DMDMi300680960

Proteomic databases

MaxQBiP0CG29
PaxDbiP0CG29
PeptideAtlasiP0CG29
PRIDEiP0CG29
ProteomicsDBi52459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215780; ENSP00000215780; ENSG00000099984
ENST00000618279; ENSP00000477540; ENSG00000277897
GeneIDi2953
KEGGihsa:2953
UCSCiuc032qyg.2 human

Organism-specific databases

CTDi2953
DisGeNETi2953
GeneCardsiGSTT2
HGNCiHGNC:4642 GSTT2
HPAiHPA000750
MIMi600437 gene
neXtProtiNX_P0CG29
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000125747
InParanoidiP0CG29
KOiK00799
OrthoDBiEOG091G0PCG
PhylomeDBiP0CG29
TreeFamiTF325759

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation

Miscellaneous databases

GenomeRNAii2953
PROiPR:P0CG29
SOURCEiSearch...

Family and domain databases

CDDicd03183 GST_C_Theta, 1 hit
cd03050 GST_N_Theta, 1 hit
InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR040077 GST_C_Theta
IPR040075 GST_N_Theta
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGST2_HUMAN
AccessioniPrimary (citable) accession number: P0CG29
Secondary accession number(s): O60665
, P30712, Q6IPV7, Q9HD76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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