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Protein

Zinc finger protein 853

Gene

ZNF853

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 620C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 853
Gene namesi
Name:ZNF853
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000236609.3
HGNCiHGNC:21767 ZNF853
neXtProtiNX_P0CG23

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000236609
PharmGKBiPA162410913

Polymorphism and mutation databases

BioMutaiZNF853
DMDMi298351896

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003951121 – 659Zinc finger protein 853Add BLAST659

Proteomic databases

MaxQBiP0CG23
PaxDbiP0CG23
PeptideAtlasiP0CG23
PRIDEiP0CG23
ProteomicsDBi52457

PTM databases

iPTMnetiP0CG23
PhosphoSitePlusiP0CG23

Expressioni

Gene expression databases

BgeeiENSG00000236609 Expressed in 148 organ(s), highest expression level in prefrontal cortex
GenevisibleiP0CG23 HS

Organism-specific databases

HPAiHPA067690

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000455585

Structurei

3D structure databases

ProteinModelPortaliP0CG23
SMRiP0CG23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 412Gln-richAdd BLAST327
Compositional biasi313 – 414Glu-richAdd BLAST102
Compositional biasi473 – 483Poly-ArgAdd BLAST11

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 620C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00630000089829
InParanoidiP0CG23
KOiK09228
OMAiQPQCEIC
OrthoDBiEOG091G0LSW
TreeFamiTF319691

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

P0CG23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHQPTPGNR GLTARMEVGP ATETFVLELQ CLEDGGPGPD TLSGGSGGSE
60 70 80 90 100
SQEEEEPQER NSSPQRPAVS APVGASEIAE ETRPGQRELQ LQQLEQQPEP
110 120 130 140 150
QQQPQHEQLQ QPQPHLELQQ QPQQDGQQQL SQLQQEKHQS VHHQELKPEL
160 170 180 190 200
QLMHQQQQLQ PQQVQEQQRL QQQQEQLQTQ QAQEQQVLQQ QEQLQQQVQE
210 220 230 240 250
QQLLQQQQEQ LQQQQLLQQQ EQLQQQQFQQ QQEQLQQQQQ LLLLQQQGQL
260 270 280 290 300
QQQLLQQQQA QLQQQLLEQQ QAQLQQQLLL QQQEQLQQQQ QQQLLQQQQE
310 320 330 340 350
QLQQQQLQPP PLEPEEEEEV ELELMPVDLG SEQELEQQRQ ELERQQELER
360 370 380 390 400
QQEQRQLQLK LQEELQQLEQ QLEQQQQQLE QQEVQLELTP VELGAQQQEV
410 420 430 440 450
QLELTPVQPE LQLELVPAAG GGGAAVPGAP AAVVVAPPGY VVVQELMVLP
460 470 480 490 500
AVAAPAVVAI PGPAGSAALT PARQRRRRRA RDRPTICGEC GKGFSRSTDL
510 520 530 540 550
VRHQATHTGE RPHRCGECGK GFSQHSNLVT HQRIHTGEKP YACSYCAKRF
560 570 580 590 600
SESSALVQHQ RTHTGERPYA CGDCGKRFSV SSNLLRHRRT HSGERPYVCE
610 620 630 640 650
DCGERFRHKV QIRRHERQLH GAGRSRGLGL LRASRPAALG GPARAEQAAT

ATAPADKAL
Length:659
Mass (Da):74,878
Last modified:June 15, 2010 - v1
Checksum:i172677BFF65DEFB1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0632798G → R. Corresponds to variant dbSNP:rs2243563Ensembl.1
Natural variantiVAR_06328030Q → R1 PublicationCorresponds to variant dbSNP:rs1806552Ensembl.1
Natural variantiVAR_063281212Q → E. Corresponds to variant dbSNP:rs11971880Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073343 Genomic DNA No translation available.
DT932678 mRNA No translation available.
CCDSiCCDS59048.1
RefSeqiNP_060030.1, NM_017560.1
UniGeneiHs.592170

Genome annotation databases

EnsembliENST00000457543; ENSP00000455585; ENSG00000236609
GeneIDi54753
KEGGihsa:54753
UCSCiuc011jwz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073343 Genomic DNA No translation available.
DT932678 mRNA No translation available.
CCDSiCCDS59048.1
RefSeqiNP_060030.1, NM_017560.1
UniGeneiHs.592170

3D structure databases

ProteinModelPortaliP0CG23
SMRiP0CG23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000455585

PTM databases

iPTMnetiP0CG23
PhosphoSitePlusiP0CG23

Polymorphism and mutation databases

BioMutaiZNF853
DMDMi298351896

Proteomic databases

MaxQBiP0CG23
PaxDbiP0CG23
PeptideAtlasiP0CG23
PRIDEiP0CG23
ProteomicsDBi52457

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457543; ENSP00000455585; ENSG00000236609
GeneIDi54753
KEGGihsa:54753
UCSCiuc011jwz.3 human

Organism-specific databases

CTDi54753
EuPathDBiHostDB:ENSG00000236609.3
GeneCardsiZNF853
HGNCiHGNC:21767 ZNF853
HPAiHPA067690
neXtProtiNX_P0CG23
OpenTargetsiENSG00000236609
PharmGKBiPA162410913
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00630000089829
InParanoidiP0CG23
KOiK09228
OMAiQPQCEIC
OrthoDBiEOG091G0LSW
TreeFamiTF319691

Miscellaneous databases

ChiTaRSiZNF853 human
GenomeRNAii54753
PROiPR:P0CG23

Gene expression databases

BgeeiENSG00000236609 Expressed in 148 organ(s), highest expression level in prefrontal cortex
GenevisibleiP0CG23 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN853_HUMAN
AccessioniPrimary (citable) accession number: P0CG23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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