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Protein

Chromosome transmission fidelity protein 8 homolog

Gene

Chtf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog
Gene namesi
Name:Chtf8
Synonyms:Ctf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443370 Chtf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272541 – 121Chromosome transmission fidelity protein 8 homologAdd BLAST121

Proteomic databases

EPDiP0CG15
MaxQBiP0CG15
PaxDbiP0CG15
PRIDEiP0CG15

PTM databases

iPTMnetiP0CG15
PhosphoSitePlusiP0CG15

Expressioni

Gene expression databases

BgeeiENSMUSG00000046691 Expressed in 269 organ(s), highest expression level in tracheobronchial tree
ExpressionAtlasiP0CG15 baseline and differential
GenevisibleiP0CG15 MM

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi229585, 1 interactor
IntActiP0CG15, 1 interactor
STRINGi10090.ENSMUSP00000135029

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF8 family.Curated

Phylogenomic databases

eggNOGiENOG410J3HT Eukaryota
ENOG4111SBI LUCA
GeneTreeiENSGT00400000025006
KOiK11270

Family and domain databases

InterProiView protein in InterPro
IPR018607 Ctf8
PANTHERiPTHR28605 PTHR28605, 1 hit
PfamiView protein in Pfam
PF09696 Ctf8, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0CG15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQIVISSTG AEGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP
60 70 80 90 100
VLIVGHHILY GKTIHLEKPF AVLVKHTPGK QDCDEPGRGT GTQYLVTALI
110 120
KNKILFKTRP KPIITNVPKK V
Length:121
Mass (Da):13,228
Last modified:June 15, 2010 - v1
Checksum:i0C03FB6A74C9541C
GO
Isoform 2 (identifier: P0CG14-1) [UniParc]FASTAAdd to basket
Also known as: DERPC
The sequence of this isoform can be found in the external entry P0CG14.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:533
Mass (Da):52,244
GO

Sequence cautioni

The sequence AAH23107 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC27186 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC40241 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030924 mRNA Translation: BAC27186.1 Sequence problems.
AK088257 mRNA Translation: BAC40241.1 Sequence problems.
AC140328 Genomic DNA No translation available.
BC023107 mRNA Translation: AAH23107.1 Sequence problems.
CCDSiCCDS57643.1 [P0CG15-1]
RefSeqiNP_663387.3, NM_145412.3 [P0CG15-1]
XP_006530897.1, XM_006530834.2
XP_017168143.1, XM_017312654.1
XP_017168144.1, XM_017312655.1
XP_017168145.1, XM_017312656.1
UniGeneiMm.490308

Genome annotation databases

EnsembliENSMUST00000175940; ENSMUSP00000135077; ENSMUSG00000046691 [P0CG15-1]
ENSMUST00000177068; ENSMUSP00000135029; ENSMUSG00000046691 [P0CG15-1]
GeneIDi214987
KEGGimmu:214987
UCSCiuc009ngo.2 mouse [P0CG15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030924 mRNA Translation: BAC27186.1 Sequence problems.
AK088257 mRNA Translation: BAC40241.1 Sequence problems.
AC140328 Genomic DNA No translation available.
BC023107 mRNA Translation: AAH23107.1 Sequence problems.
CCDSiCCDS57643.1 [P0CG15-1]
RefSeqiNP_663387.3, NM_145412.3 [P0CG15-1]
XP_006530897.1, XM_006530834.2
XP_017168143.1, XM_017312654.1
XP_017168144.1, XM_017312655.1
XP_017168145.1, XM_017312656.1
UniGeneiMm.490308

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229585, 1 interactor
IntActiP0CG15, 1 interactor
STRINGi10090.ENSMUSP00000135029

PTM databases

iPTMnetiP0CG15
PhosphoSitePlusiP0CG15

Proteomic databases

EPDiP0CG15
MaxQBiP0CG15
PaxDbiP0CG15
PRIDEiP0CG15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000175940; ENSMUSP00000135077; ENSMUSG00000046691 [P0CG15-1]
ENSMUST00000177068; ENSMUSP00000135029; ENSMUSG00000046691 [P0CG15-1]
GeneIDi214987
KEGGimmu:214987
UCSCiuc009ngo.2 mouse [P0CG15-1]

Organism-specific databases

CTDi54921
MGIiMGI:2443370 Chtf8

Phylogenomic databases

eggNOGiENOG410J3HT Eukaryota
ENOG4111SBI LUCA
GeneTreeiENSGT00400000025006
KOiK11270

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046691 Expressed in 269 organ(s), highest expression level in tracheobronchial tree
ExpressionAtlasiP0CG15 baseline and differential
GenevisibleiP0CG15 MM

Family and domain databases

InterProiView protein in InterPro
IPR018607 Ctf8
PANTHERiPTHR28605 PTHR28605, 1 hit
PfamiView protein in Pfam
PF09696 Ctf8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTF8_MOUSE
AccessioniPrimary (citable) accession number: P0CG15
Secondary accession number(s): P0C6T0, Q8BHM2, Q8R5A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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